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Friday, 26 February 2021

Green bean Processes the Anti-Proliferation Against the Onset of Cancer

By Kyle J. Norton

Cancer is a class of diseases characterized by irregular cell growth that starts in the tissue of specific organs.

Most cases of cancer overtime after penetrating into deeper layers of the affected organs, the oversize tumor can sometimes spread to other organs in the body via lymph or blood, leading to secondary metastasis.

Proliferation is a process of cancer growth associated with an abnormally high rate of cancer cells division, leading to rapid overgrowth of the tumor.

Cancer cell proliferation by dividing unlimitedly, compared to normal cells that die after a certain cell cycle division.

More precisely, a primary tumor or original tumor that the tumor progression to yield a cancerous mass. Most cancers can not be detected until they formed a small grape-like lump. Cancer cells need 42 doublings before it can produce enough cancer cells to cause death.

According to the statistics provided by the National Cancer Institute, In 2018, approximately 1,735,350 cases of cancer were diagnosed in the US and the disease also caused the death of 609,640 Americans.

Epidemiologically, the odds of cancer incidence is 439.2 per 100,000 men and women per year based on 2011–2015 statistics.
Green bean is a genus of Phaseolus Sensu Stricto, containing 55 difference species, belong to the family Fabaceae and native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans, and pole beans.

On finding a potent veggie for the prevention of cancer, researchers investigated the beans antiproliferative activity in tested cancer cell lines.

Based on the tested analysis, beans polyphenols, such as gallic acid, chlorogenic acid, epicatechin, myricetin, formononetin, caffeic acid, and kaempferol exerted a significant antioxidant expression against proteins, lipid and DNA damage in the induction of oxidative stress ranged from 1.568 ± 0.041 to 66.572 ± 3.197 mg.

Furthermore, bean extracts showed obtained from the non-pigmented samples inhibited the proliferation of the human epithelial colorectal adenocarcinoma (Caco-2) cells, human breast cancer cells MCF-7, and A549 NSCLC cell line used in the experiment.

More importantly, the qualitative and quantitative differences in phenolic composition between the groups of beans influenced antioxidant and proliferative efficacy biologically.

In other words, all beans groups exert significant anti-proliferation in the cancer cells depending on bean types but did not show significant differences in the biological activities within the same variety, before and after cooking.


Taken altogether, green beans may be used as an adjunct therapy for the prevention and treatment of cancer, pending to the confirmation of larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Phenolic Composition and Antioxidant and Antiproliferative Activities of the Extracts of Twelve Common Bean (Phaseolus vulgaris L.) Endemic Ecotypes of Southern Italy before and after Cooking by Maria Neve Ombra,1 Antonio d’Acierno,1 Filomena Nazzaro,1 RiccardoRiccardi,2 Patrizia Spigno,2 Massimo Zaccardelli,3 Catello Pane,3 MenaMaione,1 and Florinda Fratianni. (Hindawi)

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