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Monday 6 December 2021

Cruciferous vegetables Kill Non-Small Cell Lung Cancer in Vitro

By Kyle J. Norton

The lung is a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells' needs and exhaling carbon dioxide from the bloodstream.

Cancer is a class of disease characterized by cell growth disorderly and uncontrollably in the tissues and organs.

Lung cancer is a medical condition characterized by abnormal growth of the cells in the lung's tissue.

The most common form of primary lung cancers is derived from epithelial cells.

According to the statistics provided by the American Cancer Society, in the US, lung cancer is the leading cause of cancer deaths.

In 2007, lung cancer causes the death of 158,683 people, including 88,329 men and 70,354 women.

In other words, 1 in 16 people in the US will be diagnosed with lung cancer in their lifetime. Approximately over 220,000 people in the US will be diagnosed with lung cancer this year.

Believe it or not, 60% to 65% of all new lung cancer diagnosed are among people who have never smoked or are former smokers.

Non-small cell lung cancer, the most common type of lung cancer, usually grows and spreads methodically and predictably.

The most common risk factors of non-small cell lung cancer (NSCLC) are long term smoking and people exposed to long-term second-hand smoke.

The most common symptoms of lung cancer are shortness of breath, cough up blood, pain, fluid in the chest, wheezing and hoarseness accompanied by general symptoms shared by other types of cancer.


Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding a potential compound for the prevention and treatment of cancer, researchers examined
the effect of the combination of two isothiocyanates, i.e. allyl isothiocyanate and sulforaphane on A549 lung cancer cells.

According to the results of the experiment, the combination treatment worked synergistically to induce stronger growth inhibition of the cancer cells compared to the singular treatment.

The combination treatment caused cell cycle arrest, suppressed cell migration and apoptosis compared to a singular treatment by modifying the expression of key proteins associated with the cellular processes.

Most importantly, the combined treatment also exhibited the expression of ROS to induce the cytotoxic activity against the tested cell line.

Based on the findings, researchers said, "our results have demonstrated the potential of different isothiocyanates used in combination to produce enhanced protective effects against carcinogenesis".

Taken altogether, cruciferous vegetables processed a high amount of allyl isothiocyanate and sulforaphane may be considered functional foods for the prevention of non-small cell lung cancer pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Synergistic chemopreventive effect of allyl isothiocyanate and sulforaphane on non-small cell lung carcinoma cells by Rakariyatham K 1, Yang X, Gao Z, Song M, Han Y, Chen X, Xiao H. (PubMed)

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