Cranberry Inhibits the Onset of Insulin Resistance

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

Diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Insulin resistance is a condition in which cells that convert glucose to energy in the muscles, body fat, intestine, and liver ignore the signal o the hormone insulin signaling.

 In other words, signals sent out by the hormone insulin was ignored by the cell of the muscles, body fat, and liver that process the function to convert glucose into energy.

Epidemiologically, people with insulin resistance are associated with an increased risk of prediabetes, type 2 diabetes and chronic conditions such as heart attacks, strokes, and cancer.

According to statistics, over 100 million Americans are living with insulin resistance. Approximately 1 in 3, including half of those age 60 and older have a silent blood sugar problem known as insulin resistance.

There are no single causes of insulin resistance, Epidemiologically, aging, ethnicity, overweight or obese, too much belly fat, physical inactivity, smoking and certain medical conditions such as Cushing’s disease or polycystic ovary disease are some of the prevalent factors that induce the risk of the condition.

However, most people with some of the aforementioned risk factors have never developed insulin resistance.

Most cases of insulin resistance in the Western world are involved in the clogged up insulin receptors.
As the signals of hormone insulin are blocked, insulin resistance develops, leading to more production of insulin by the body.

Over time insulin resistance that leads to damage to the beta cell in the pancreas, an early condition of prediabetes and types 2 diabetes.

The most common symptoms of patients with insulin resistance are tiredness, hunger and difficulty concentrating.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of prediabetes, researchers investigated the potential of a polyphenol-rich extract from cranberry (CE) on metabolic disorders in DIO-mice

Mice selected to the study were pre-fed either a Chow or a High Fat-High Sucrose (HFHS) diet for 13 weeks to induce obesity and then treated either with CE (200 mg/kg, Chow + CE, HFHS + CE) or vehicle (Chow, HFHS) for 8 additional weeks.

According to the tested analysis, CE did not reverse weight gain or fat mass in Chow- or HFHS-fed mice.

However, HFHS + CE fully reversed hepatic steatosis by stimulating the genes involved in lipid catabolism (e.g., PPARα) and inhibiting the production of several pro-inflammatory genes in the liver.

These results were attributed to the efficacy of HFHS + CE in the improvement of the levels of glucose tolerance and normalization of insulin sensitivity in the tested mice.

Moreover, the ratio of gut microbiota was significant to improve in the HFHS + CE group compared to HFHS controls.

Taken altogether, cranberry combined with conventional medicines may be considered a remedy for the improvement of glucose tolerance and insulin sensitivity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A polyphenol-rich cranberry extract reverses insulin resistance and hepatic steatosis independently of body weight loss by Anhê FF1, Nachbar RT2, Varin TV3, Vilela V4, Dudonné S5, Pilon G6, Fournier M7, Lecours MA8, Desjardins Y9, Roy D10, Levy E11, Marette A. (PubMed)