Broccoli Kills Non‑Small Cell Lung Cancer Cells in Vitro

By Kyle J. Norton

Cancer is a class of disease characterized by cell growth disorderly and uncontrollably in the tissues and organs.

The lung is a vital organ in humans, located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells' need and exhaling carbon dioxide from the bloodstream.


Lung cancer is a medical condition characterized by abnormal growth of the cells in the lung's tissue.

The most common form of primary lung cancers is derived from epithelial cells.

According to the statistics provided by the American Cancer Society, in the US, lung cancer is the leading cause of cancer deaths.

In 2007, lung cancer causes the death of 158,683 people, including 88,329 men and 70,354 women.

Non-small cell lung cancer, the most common type of lung cancer grown and spread methodically and predictably, includes
* Squamous-cell carcinoma often found in an outer area of the lung.

*Large-cell carcinoma found in the center of the lung by an air tube.

* Adenocarcinoma found in any part of the lung.

Broccoli is a mustard/cabbage plant, belong to the family Brassicaceae. The veggie has large flower heads, usually green in color and the mass of flower heads surrounded by leaves and evolved from a wild cabbage plant on the continent of Europe.

On finding a potential plant that processes anticarcinogenic activity, researchers examined the chemotherapeutic and anti‑cancerogenic capacities of SFN in non‑small cell lung cancer cell lines.

In vitro, according to the results of the non‑small cell lung cancer cell line H1299 was treated with increasing concentrations of SFN (5, 10 and 15 µM) for two days,

* SFN‑induced cell cycle arrest was associated with a decrease in cyclin B1 expression in cell cycle regulation.

* Non-small lung cancer cells treated with SFN also induced the higher levels of cyclin D1 and cyclin K in the induction of cell cycle arrest or apoptosis.

In other words, SFN induced cancer cell apoptosis, cell cycle and expression of selected cell cycle‑associated proteins Cyclin B1, cyclin D1 and cyclin K.

Taken altogether,  broccoli processed a high amount of SFN may be considered a functional food for the prevention and treatment of non‑small cell lung cancer, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Expression of cyclin B1, D1 and K in non‑small cell lung cancer H1299 cellsfollowing treatment with sulforaphane by Żuryń A1, Krajewski A1, Klimaszewska-Wiśniewska A2, Grzanka A1, Grzanka D. (PubMed)