Ashwagandha the Antiaging Herbal Medicine

By Kyle J. Norton

Skin aging is a natural process that can not be stopped. However, there are some people have younger-looking facial skin compared to their biological age.

The evidence of skin aging can be visible by increasing wrinkles and sagging skin.

Skin is the largest organ in the human body. The skin not only shields us against the invasion of foreigner pathogens but also serves as the third detoxed organ besides the liver and kidney.

Additionally, the skin also protects the skeletons and internal organs against the mechanical impacts and pressure, variations in temperature, micro-organisms, radiation, and chemicals.

However, when skin ages, it also reduces the function of the aforementioned protection, seen in the elderly.

Besides biological causes of skin aging, long-term exposure to sunlight, particularly UVB is one of the major factors associated with damages of elastin, leading to wrinkles, sagging skin that loses stability to rebound from the stretch.

According to the free radical theory of aging, free radical bombardment over time can cause oxidative damage to the enzymes, other protein, unsaturated fatty acid, phospholipids, DNA and RNA, leading widespread cell damage including the skin cells after attacking the lipid bilayers of the cell walls.

In other words, according to the theory, free radical cause internal and external cell damage, that lead to aging cells.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the promotion of healthy aging, researchers examined the effects of major component of leaf extract of Ashwagandha (i-Extract) and within one withanone ((i-Factor) protected the normal human fibroblasts against the toxicity.

According to the tested results, in vitro both applications increase the division potential of normal human cells by protecting the cells against oxidative damage and induction of proteasomal activity.

Furthermore, the application also decreased the accumulation of molecular damage, by inhibiting the senescence-specific beta-galactosidase activity and the senescence marker protein, p21(WAF-1)associated with the process of deterioration of cells with age.

Based on the findings, researchers said, "we provide the first example of phytochemical(s) (i-Extract and withanone) that have ... antiaging activities and point to the molecular link between aging and cancer".

Taken altogether, Ashwagandha may be considered a functional herb that protects the cellular damage against aging, pending to the result of larger sample size and multicenter study



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Deceleration of senescence in normal human fibroblasts by withanone extracted from ashwagandha leaves by Widodo N1, Shah N, Priyandoko D, Ishii T, Kaul SC, Wadhwa R. (PubMed)