3,3'-Diindolylmethane May Induce immune-Toxicity if Overdosed

By Kyle J. Norton

The immune system is the set of cells and their activity against antigens or infectious agents that comprises the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections.

It is one of the body's defense system against diseases.

Immune dysfunction is a chronic condition, depending on the parts of the immune system affected.

There are 2 types of immune dysfunction
* The underactive immune system is also known as the weakened immune system. People with the underactive immune system are susceptible to infection, recurrent infections.

The most common symptoms of the underactive immune system are infection including frequent and recurrent pneumonia, bronchitis, sinus infections, ear infections, meningitis or skin infections and Inflammation and infection of internal organs.

However, blood disorders, such as low platelet counts or anemia and digestive dysfunction are also some of the common symptoms found in patients with the underactive immune system.

* The overactive immune system is also known as autoimmune diseases. In this case, patients suffer diseases associated with the immune system that attacks the body tissues.

Immunomodulation is an action with a profound and positive effect in regulated immune response and function through activation of antibody formation or the inhibition of white blood cell activity.

On finding a potential plant that enhances immune functioning, researchers compared the effects of 3,3'-Diindolylmethane (DIM), a major product of indole-3-Carbinol isolated from genus Brassica, on various immune-modulatory activity in animal models and in vitro studies.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

According to the tested analysis, the DIM treatment showed multiple immunotoxic effects in decreasing in various immune cells (F4/80(+), CD11c(+), CD19(+), and CD3(+) cells) in the spleen.

Furthermore, the DIM treatment also induced the expression of splenic white pulp atrophy, an increase in immune cell apoptosis, and decreased expression of various toll-like receptors (TLRs), a class of proteins that play a key role in the innate immune system.

The action of 3,3'-Diindolylmethane that modulates the immune functioning was attributed to the promotion of the caspase-3 activity and ratio of proteins associated with cell deaths and survivals in regulating programmed cell death or apoptosis.

Based on the findings, researchers said, "This new information about the immunotoxic roles of DIM in a newborn mouse model may provide valuable clues for the development of a safe supplement, especially one designed for human infants".

Taken altogether, DIM supplements may process immune toxic activity if overdosed.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-Diindolylmethane induces immunotoxicity via splenocyte apoptosis in neonatal mice by Roh YS1, Cho A, Islam MR, Cho SD, Kim J, Kim JH, Lee JW, Lim CW, Kim B. (PubMed)