Herbal Ashwagandha Modulates the Immunomodulatory Effects on Colon Cancer Developing

By Kyle J. Norton

The immune system included the thymus and bone marrow, as well as secondary lymphatic tissues including spleen, tonsils, lymph vessels, lymph nodes, adenoids, skin, and liver, is the body's defense against infectious organisms and foreign invaders.

The immune dysfunction can be classified into
* The underactive immune system is also known as the weakened immune system. People with the underactive immune system are susceptible to infection, recurrent infections.

Most common symptoms of the underactive immune system are infection including frequent and recurrent pneumonia, bronchitis, sinus infections, ear infections, meningitis or skin infections and Inflammation and infection of internal organs.

However, blood disorders, such as low platelet counts or anemia and digestive dysfunction are also some of the common symptoms found in patients with the underactive immune system.

* The overactive immune system is also known as autoimmune diseases. In this case, patients suffer diseases associated with the immune system that attacks the body tissues.

Dust, mold, pollen, and food over-reaction are some of the most common symptoms of patients with an overactive immune system. However, in severe cases, over the active immune system can attack the body tissues, leading to chronic diseases such as rheumatoid arthritis, systemic lupus erythematosus (lupus), inflammatory bowel disease (IBD), multiple sclerosis (MS) and type I diabetes.

According to the BC health link, autoimmune tests may include anti-dsDNA, anti-RNP, anti-Smith (or anti-Sm), anti-Sjogren's SSA and SSB, anti-scleroderma or anti-Scl-70, anti-Jo-1, and anti-CCP. Antibody against cardiolipin also may be tested depending on the type of symptoms.

In other words, if your tested results showed that you have several of these antibodies in high amounts, you may have an autoimmune disease.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of cancer, researchers examined the effects of Withania somnifera (Ashwagandha) on immunomodulation was tested in experimental azoxymethane-induced colon cancer in an animal model.

The study included Swiss albino mice induced colon cancer by Azoxymethane 15 mg/kg body weight was injected intraperitoneally once a week for 28 days before treatment of Withania somnifera.

According to the tested analysis, Azoxymethane induced the appearance of aberrant crypt foci (ACF) in the colons of the experimental mice. Furthermore, the biomarker and expression of ACF were found to correlate to the development of colon tumors.

Application of 400 mg/kg body weight of W. somnifera extracts once a week for four weeks on orally Azoxymethane induced colon cancer mice showed a significant effect on immunomodulatory activity by significantly altering the level of leucocytes, lymphocytes, neutrophils, immune complexes, and antibody immunoglobulins (Ig) A, G, and M.

In other words, the azoxymethane-induced colon cancer and immune dysfunction were controlled by the application of W. somnifera. 

Based on the findings, researchers said, " These results suggested that the immunomodulatory effects of W. somnifera could be useful in the treatment of colon cancer".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and treatment of colon cancer through its immunomodulatory effects, pending to the result of larger sample size and multicenter study



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Immunomodulatory effects of Withania somnifera on azoxymethane induced experimental colon cancer in mice by Muralikrishnan G1, Dinda AK, Shakeel F. (PubMed)
(2) Autoimmune Disease Tests. Test Overview by Healthlink BC