Healthy Food Onion Inhibits Lung Cancer in Vivo

By Kyle J. Norton


The lung is a vital organ formed part of the respiratory system located near the backbone on either side of the heart that inhales oxygen from the air to the bloodstream and exhales carbon dioxide from the bloodstream.

Lung cancer is a medical condition caused by the abnormal growth of the cells in the lung's tissue. Most common form of primary lung cancers is derived from epithelial cells. 

According to the statistic, in the US, approximately 541,000 Americans are living with lung cancer at some points in their lives. In 2018, approximately 234,000 new cases of lung cancer were diagnosed, representing about 13 percent of all cancer diagnoses.

The exact causes of lung cancer are unknown. Epidemiologically, the prevalent factors associated with an increased risk of lung cancer are

*Smoking

Smoking is a major cause of lung cancer by causing oxidation stress to the lung due to chemical substances (carcinogens) in the cigarette over time.

* Second-hand smoke
Prolonged exposure to second-hand smoke can also increase the risk of lung cancer.

* Exposure to certain chemicals
 Risk of lung cancer is increased for people who inhale or expose certain industrial chemical such as radon gas, arsenic, chromium, nickel, etc. in the workplace.

* Family history
Risk of lung cancer increased if one of the members of the direct family has lung cancer.

*  Lung disease
Risk of lung cancer is increased if you have or previously had certain types of lung disease

* Excessive alcohol drinking
Alcohol intake of more than 2 drinks per day is associated with a small increased risk of lung cancer. 

Some researchers suggested that the risk of lung cancer can be decreased by

* Quit smoking
According to statistic, approximate 87% of lung cancer deaths are caused by smoking.

*  Eating more fruits and vegetables
These foods contain a high amount of antioxidants which enhance the immune system against the forming of free radicals and prevent the alternation of cell DNA cause of abnormal cell growth.

* Avoid Second smokes
Second smoke contains the same amount of carcinogens, exposure to it can increase the risk of lung cancer.

* Avoid environmental chemicals
Avoid exposure to certain industrial chemicals such as radon gas, arsenic, chromium, nickel, etc.. In the workplace, deal with them by taking maximum precautions and prevention.

* Reduced alcohol intake
Researchers found that increased risk of lung cancer for people who have more than 2 drinks a day.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the treatment of cancer, researchers examined the effects of onionin A (ONA) derived from the onion in the inhibition of tumor-associated macrophages in the M2 phenotype.

According to the tested analysis.

* Onionin A (ONA) inhibits macrophage polarization into the M2 phenotype associated with tumorigenesis by antagonizing the cytotoxic activity immune cells.

* Onionin also exerted immunosuppressive activity and tumor proliferation, by suppressing signal transducer and activator associated with tumor proliferative promotion.

* In lung tumor, ONA administration significantly suppressed subcutaneous tumor development and lung metastasis in tumor-bearing mice.

* ONA also increased the number of infiltrating lymphocytes against the tumor proliferation in tumor tissues.

The efficacy of  ONA against the onset and progression of od lung cancer was probably involved in the regulation of tumor proliferation by inhibiting cell-cell interactions between macrophages and tumor cells.

Based on the finding, researchers said, "NA administration enhanced the antitumor effects of cisplatin in the tumor-bearing mice".

Taken altogether, onion processed a higher mount of onionin A (ONA) may be considered a remedy for the prevention and treatment of lung cancer, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Onionin A, a sulfur-containing compound isolated from onions, impairs tumor development and lung metastasis by inhibiting the protumoral and immunosuppressive functions of myeloid cells by Fujiwara Y1, Horlad H1, Shiraishi D1, Tsuboki J1, Kudo R1, Ikeda T2, Nohara T2, Takeya M1, Komohara Y. (PubMed)
(2) Lung Cancer by Kyle J. Norton