Healthy Food Onion the Anti Acute and Chronic Inflammatory Functional Food

By Kyle J. Norton

Inflammation is a natural defense of the body in which the immune system white blood cell on the first line of defense try to destroy stimuli and foreign pathogens which try to enter the body through the wound or injury.

More precisely, in the acute phase of infection, after receiving the message transmitted by the central nervous system, the immune macrophages stimulates the production of blood palette to cover the affected site and production of pro-inflammatory cytokines to protect the body against harmful microorganisms.

Some anti-inflammatory cytokines in this phase may also switch to proinflammatory activity, causing overproduction of proinflammatory cytokines.

Depending on the size and severity of the injury or damage, most cases of infection are ended in the acute phase. The wound is healed within a few days or weeks.

In other words, if the immune macrophages destroy all  foreign pathogens in the acute phase of infection, the inflammatory progress proceeds to other stages including the stage one of acute phase of infection followed by the repair and regeneration stage, where collagen fibers are formed then by the remodeling and maturation stage, where the new tissue continue to remodel, strengthen and improve.

However, in some cases, overexpression of pro-inflammatory cytokines may cause damage and death of healthy cells, leading to the formation of scars.

Most common symptoms of the acute phase of infection area pain, swelling and redness in the affected areas.

Chronic inflammation occurs when the immune system can not destroy all invaders within a set period, it will compromise, leading to chronic low-grade inflammation, the major cause of various chronic illness, including cardiovascular disease and diabetes.

The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

With an aim to find a natural compound that process anti-inflammatory activity researchers examined the epidemiological studies of onion and garlic on vitro and vivo.

Epidemiologically,

* Onion sulfur components inhibit cyclooxygenase (COX) the enzymes that promote inflammation, pain, and fever.

* Levels of lipoxygenase associated with pro-inflammatory effects was also inhibited by the onion sulfur components.

* Moreover,  mouse macrophages stimulated by lipopolysaccharide (LPS), onion sulfur components decreased the expression of the pro-inflammatory cytokines.

* Compared to several nonsteroidal anti-inflammatory drugs, ajoene found in onion also inhibited the release of PGE2 by blocking the activation of  COX-2 enzyme activity at a dose-dependent manner.

Taken altogether, onion may be considered a remedy for the prevention and treatment of inflammation, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)