Turmeric Protects the Neurons Against the Risk of Neurological Disease

By Kyle J. Norton

Neurological disorders are class of diseases associated with the brain, the spinal cord including the nerves that connect them.

Most common diseases of neurological disorders are dementia, including ALS. PD, Alzheimer's disease, birth defects of the brain and spinal cord, brain injury and tumor.

Back pain associated with the related nerve damage is one of the common complaints in the US that send many patients to seek help from their doctor. Believe it or not, 80% of the US population will experience back pain at some time in their lives.

There is no single cause of neuro-dysfunction. Lifestyle, infections, genetics, and nutrition-related disease, environment, and physical injuries have been found to some major prevalent factors that induce the onset of neurological abnormalities.

Furthermore, neurological disorders have been found to facilitate psychological symptoms such as anxiety and depression and physical symptoms, depending totally on the neurons affected, including partial or complete paralysis muscle weakness seen on post-stroke patients, difficulty reading and writing and poor cognitive abilities such as patients with dementia.

According to the American Addiction Center, if you experience some of the below symptoms persistently, inclduing headaches, blurry vision, persistent fatigue, changes in behavior, numbness in the legs or arms, changes in coordination or balance weakness, slurred speech and tremors, you should seek help from the professionals immediately, as these may be the first signs of neurological disorders.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema,
inflammations, etc.

On finding a potent compound for the treatment of neurological disease, researchers examined Curcuminoids, polyphenol compounds from turmeric (Curcuma longa) effect on Alzheimer's disease (AD).

According to the tested analysis,

* Curcuminoids attenuation of mitochondrial dysfunction-induced neurons oxidative stress and inflammatory responses in patients with AD.

* The bioactive compound inhibited the immune response in the promotion of the production of pro-inflammatory cytokines such as COX-2, and iNOS

* Furthermore, curcuminoids also bind to β-amyloid (Aβ) plaques to inhibit amyloid accumulation and aggregation in the brain of AD patients.

* More importantly, the expression of the toxic Aβ oligomer formation and oligomer-dependent Aβ toxicity were also inhibited by the injection of curcuminoids.

Curcuminoids efficacy of in patients with AD was also found in diseases associated with multiple sclerosis (MS), glaucoma, age-related macular degeneration (AMD), particularly in the prevention α-synuclein aggregation in Parkinson's disease (PD).

Additionally, neurological damage caused by heavy metal poisoning was also attenuated by the injection of curcuminoids.

Based on the results, researchers wrote, " These results demonstrate curcuminoids may be potentially effective therapeutic means to treat neurodegenerative diseases. A bulk of patents discloses methods to improve the bioavailability of curcuminoids for therapeutic development".

Taken altogether, turmeric processed abundantly bioactive compound curcuminoids may be considered supplements for the prevention and treatment of neurological diseases, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Benefits of curcumin in brain disorders by Bhat A1,2, Mahalakshmi AM1,2, Ray B1,2, Tuladhar S1,2, Hediyal TA1, Manthiannem E1, Padamati J1, Chandra R3,4, Chidambaram SB1,2, Sakharkar MK. (PubMed)
(2) Curcuminoids in neurodegenerative diseases by Kim DS1, Kim JY, Han Y. (PubMed)