Herbal Ashwagandha Inhibits the Risk of Chronic Generalized Periodontitis

By Kyle J. Norton

Gingivitis is a common and mild form of periodontal disease caused by inflammation of the gingiva, leading to symptoms of irritation, redness, and swelling of the gum that lines the base of the teeth.

Gingivitis dental plaques formed around the base of the teeth are sticky biofilm of bacteria associated with the interaction of the food intake and bacteria in the mouth. Over time, if untreated, the condition can lead to periodontitis and advanced periodontitis.

At this early stage, the bone and connective tissue that hold the teeth in place are not yet affected. The problems can be reversed by more frequent and proper brushing and flossing.

Most common cause of gingivitis is poor hygiene. Epidemiologically, risk factors induce the onset of gingivitis are smoking or chewing tobacco. diabetes and long-term use of certain medication including oral contraceptives, steroids, anticonvulsants, calcium channel blockers.

Some people under treatment of chemotherapy may also experience symptoms of gingivitis.

Periodontitis is a severe stage of gingivitis that damages the soft tissue and destroys the bone that supports your teeth, leading to teeth loosen or tooth loss.

Periodontitis can be classified into

* Chronic periodontitis is caused by plaque buildup and involves slow deterioration of the gums and bone and loss of teeth if not treated. The condition is a common condition that affects mostly adults.

* Aggressive periodontitis found mostly in childhood or early adulthood. The condition is rare that causes rapid progression of bone and tooth loss if untreated.

* Necrotizing periodontal disease is a severe infection that causes the death of gum tissue, tooth ligaments and supporting bone.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the treatment of oral health, researchers examined the effects of WA on periodontitis.

In vitro, Herbal ashwagandha possessed marked anti-inflammatory effect against denaturation of proteins associated with the loss of the quaternary structure, tertiary structure, and secondary structure, probably through the herbal alkaloid and withanolide contents.

Furthermore, herbal ashwagandha also induced adaptogenic, immunomodulating, antibacterial, anti-inflammatory against on the onset of periodontitis.

The enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase produced by the host are the increased by the administration of WA against bacterial-induced inflammatory periodontitis.

Moreover, Ashwagandha supplementation also showed to process activity to act as an adjunct to scaling and root planing(SRP) in chronic periodontitis(CP) patients by inhibiting oxidative stress (OS) and increased levels of acute-phase proteins associated with gingival inflammation and periodontitis.

Based on the findings, researchers said, "Changes in peripheral blood cellular and molecular components can be seen in patients with periodontitis, as periodontitis includes inflammatory changes of the periodontal tissues".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of periodontitis, pending to the result of larger sample size and multicenter study



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of Ashwagandha on Salivary Antioxidant and Serum c Reactive Protein in Chronic Generalized Periodontitis by NIH
(2) Periodontitis by Mayo Clinic