Broccoli Sprouts, The Neuro-Protective Veggie

By Kyle J. Norton

Neuroprotection an action involved the use of a natural substance to protect the integrity of neurons against damage or death.

In other words, neuroprotection is the process to protect the brain functionings.

Neurodegenerative diseases are a class of conditions associated with the progressive loss of neurons in the brain caused by several mechanisms, including toxicity and oxygen deficiency.

Most common disease associated with neurodegenerative diseases is dementia, a cluster of conditions included Parkinson’s, Alzheimer’s, and Huntington’s disease, leading to a negative influence the body's functioning, including balance, movement, talking, breathing, and heart function.

There is no single cause of the progressive death of brain neurons. Epidemiologically, genetic preposition, medical condition, such as alcoholism, brain cancer or a stroke in the brain are some of the most common prevalent factors found in patients with neurological diseases

A prolonged period of toxins, toxic chemicals accumulated that affects the brain function also have a strong impact to induce the onset of the disease.

Symptoms of neurotoxicity are totally depending on the degree of toxicity. Some symptoms may take some time to develop. However, in most cases, symptoms may appear immediately after exposure.

Depending on the area and location of neurons damage, weakness or numbness, loss of memory, vision, headache change of cognitive and behavioral and sexual dysfunction are the most common symptoms found in people with neurotoxicity.

According to the WHO, neurological disorders, ranging from epilepsy to Alzheimer disease, from stroke to headache, affect up to one billion people worldwide.

In older adults, the increase in age has been found to affect the progressive onset of neurodegenerative diseases.

Dr. Hung CW and colleagues wrote, " In the human body, it is estimated that cell division and metabolism occurs exuberantly until about 25 years of age. Beyond this age, subsidiary products of metabolism and cell damage accumulate, and the phenotypes of aging appear, causing disease formation".

And, " Among these age-related diseases, neurodegenerative diseases have drawn a lot of attention due to their irreversibility, lack of effective treatment, and accompanied social and economical burdens".

Broccoli is a mustard/cabbage plant, belonging to the family Brassicaceae. The veggie had large flower heads, usually green in color and the mass of flower heads is surrounded by leaves that is evolved from a wild cabbage plant on the continent of Europe.

On finding a potent compound for the protection against brain disease, researchers examined the neuroprotective effect of broccoli sprouts on SH-SY5Y cells.

According to the results of the SH-SY5Y cells used in the study were treated with the fragment Aβ 25-35 by two crude juices of broccoli sprouts containing different amounts of phenolic compounds, researchers found that Aβ-induced cytotoxicity and apoptotic cell death were inhibited the administration of both juices.

In other words, both juices protected the integrity of the neurons and inhibited the nuclear chromatin condensation and apoptotic body formation induced by Aβ injection.

The efficacy of broccoli sprout juice against the neuro-toxicity was attributed to the modulation of the mitochondrial function and the HSP70 gene transcription and expression that dissociate cytotoxic stress in the neurons.

Furthermore, oxidative stress in the brain tissues was also ameliorated by the juices by increasing the host levels of antioxidant enzymes such as heme oxygenase-1, thioredoxin, thioredoxin reductase.

More precisely, broccoli sprout juice protected the neuron against toxicity by dissociating cytotoxic and oxidative stress.

In the comparison of the neuroprotection of 2 juices, researchers said, "Although the effects of the two juices were similar, the juice enriched in phenolic compounds showed greater efficacy in inducing the activation of the Nrf2 signaling pathway (involved in systematic inflammatory response)".

Taken altogether, broccoli sprout may be considered a functional food for the promotion of brain health, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Neuroprotective Effect of Brassica oleracea Sprouts Crude Juice in a Cellular Model of Alzheimer's Disease by Masci A1, Mattioli R2, Costantino P2, Baima S3, Morelli G3, Punzi P4, Giordano C5, Pinto A1, Donini LM1, d'Erme M6, Mosca L. (PubMed)

(1) Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in in Vitro and in Vivo Models of Parkinson's Disease by Morroni F1, Sita G1, Djemil A2, D'Amico M3, Pruccoli L3, Cantelli-Forti G3, Hrelia P1, Tarozzi A. (PubMed)
(3) Ageing and neurodegenerative diseases by Hung CW1, Chen YC, Hsieh WL, Chiou SH, Kao
CL. (PubMed)