Herbal Turmeric Suppresses the Initiation, Progression, and Proliferation of Acute Myeloid Leukemia (AML)

By Kyle J. Norton

Leukemia is a condition characterized by an abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending to the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

Bone marrow is soft tissue inside the hollow center of the major bone. including spine, pelvis, underarm, leg. etc.

Acute leukemia is a condition caused by a rapid increase in the numbers of extreme immature white blood cells which appear in the bloodstream in the other parts of the body, including tissue and organs, Acute leukemia can also be classified into
* Acute lymphoblastic leukemia (ALL)
Acute lymphocytic leukemia (ALL) is a type of cancer of the abnormal growth of extreme immature lymphocytes overproduced by the bone marrow and/or lymphatic system. The condition has a tendency to multiply quickly, leading to the death to normal white blood cells in the bone marrow and/or lymphatic system.

In ALL, lymphocytes appear immature in the bloodstream. Acute lymphoblastic leukemia (ALL) is the most common children forms of leukemia with about 80% of all cases.

* Acute myeloid leukemia (AML)
Acute myelogenous leukemia (AML) is a cancer of myelogenous lining caused by the rapid growth of abnormal granulocytes accumulated in the bone marrow, interfering with the normal blood cells. In AML, granulocytes appear immature in the bloodstream.

Most common risk factors associated with the risk of AML are 

*  Age
Acute myelogenous leukemia (AML) occurs mostly in adults with increased risk with age.

* Gender
Men have an increased risk of Acute myelogenous leukemia (AML) than that of women.

* Radiation
Children with a previous high dose of radiotherapy and chemotherapy have an increased risk of acute lymphoblastic leukemia.

* Exposure to environment chemicals
Exposure to certain chemicals can increase the risk of the disease.

* Previous cancer treatment.
Previous cancer treatment of chemotherapy and radiation therapy increase the risk of AML.

* Smoking
AML is linked to cigarette smoke, as a result of cigarette carcinogens.

* Genetic disorders
Certain inherited genetic disorders, such as Down syndrome, Fanconi anemia, IgA deficiency, etc. increase the risk of the disease.

According to the statistic proved by the American Cancer Society, in 2019, approximately 21,450 new cases of acute myeloid leukemia (AML) will be diagnosed in adults. The disease also causes the
of 10,920 deaths of American adults.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to find a natural compound for the treatment of acute myeloid leukemia cancer, researchers examined the curcumin, a bioactive compound from turmeric, eliminated cancer stem cells (CSCs) in some cancers.

On acute myeloid leukemia cells treated with increasing concentrations of curcumin showed a significant decrease in the markers associated with CSCs.

ALDH activity as a common marker that mediates the metastasis is also inhibited by the injection of curcumin through a decrease in the percentage of ALDH-positive cells.

Colony formation associated with cancer cell proliferation and progression was also suppressed by the activity of curcumin.

Proteins involved in uncontrolled cellular proliferation and oncogene in several other cancers and promotion of cellular division were also inhibited by the administration of the phytochemical.

In other words, curcumin suppression the initiation, progression, and proliferation of acute myeloid leukemia through several mechanisms, including cell cycle arrest, apoptosis, and anti-proliferation.

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of acute myeloid leukemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evaluation of curcumin, a natural product in turmeric, on Burkitt lymphoma and acute myeloid leukemia cancer stem cell markers by Li Y1, Domina A2, Lim G1, Chang T2, Zhang T. (PubMed)