Herbal Turmeric Normalizes the Levels of Blood Cholesterol (LDL) and Triglycerides (TC) in Patients with Increased Risk of Cardiovascular Disease (CVD)

By Kyle J. Norton


Abnormal blood lipids profile included high cholesterol and triglycerides has been found to associate with an increased risk of developing cardiovascular disease (CVD).

Lipid profile test is a blood test that measures the levels of cholesterol and triglycerides in patients with a high risk of cardiovascular disease.

There are 2 types of blood cholesterol
* The low-density lipoprotein (LDL) produced by either the liver or dietary sources plays an essential role in the production of vitamin D, a steroid hormone, building strong cell membranes and aiding the digestive function in the absorption of nutrients.

* The other type of cholesterol is high-density lipoprotein (HDL) which has a unit function in returning the blood cholesterol to the liver for future use.

The healthy ration of LDL/HDL is any number less than 4.

Triglycerides (TC) are a type of fat stored in fat cells due to excess calories consumed. Triglycerides are converted to energy when it is needed by the body.

Although Triglycerides (TC) is needed for good health, however, regularly eat more calories than you burn, may induce hypertriglyceridemia, one of the leading cause of hardening of the arteries or thickening of the artery walls.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a natural ingredient for the normalization of LDL and TC, researchers conducted a meta-analysis to assess the efficacy and safety of turmeric and curcumin in lowering blood lipids in patients at risk of cardiovascular disease (CVD).

The study included the search for comprehensive literature search was conducted on PubMed, Embase, Ovid, Medline and Cochrane Library databases to identify randomized controlled trials (published as of November 2016) satisfied the standard guidelines and criteria.

The 7 eligible studies including 649 patients showed that turmeric extract and curcumin significantly reduced serum LDL-C and TG levels, compared to those in the control group.

Administration of both turmeric extract and curcumin lower serum TC levels in patients with metabolic syndrome. However, turmeric extract possibly has a greater effect on reducing serum TC levels compared to those of curcumin.

Both turmeric extract and curcumin showed no effect on the serum HDL-C levels and are safe.

Dr. Qin S, the lead scientist said, "Turmeric and curcumin may protect patients at risk of CVD through improving serum lipid levels. Curcumin may be used as a well-tolerated dietary adjunct to conventional drugs".

In order to obtain more information about turmeric activity on lipid profile, researchers investigated the efficacy of curcuminoid fraction from Curcuma xanthorrhiza and its curcuminoid cider in reducing blood cholesterol level and four genes related to oxidative stress.

The study included 24 male Sprague-Dawley rats divided into six groups, namely normal group diet, high-cholesterol diet (HCD) 2%, HCD + 100 mg/kg b.w. curcuminoid fraction, HCD + 300 mg/kg b.w. curcuminoid fraction, HCD + cider 1% v/v, and HCD + curcuminoid cider 2% v/v for 4 weeks.

All curcuminoid cider at 2% v/v treatment groups showed a significantly lowered total cholesterol level compared to those of positive control.

According to the results from the Real-time PCR data, both curcuminoid fractions (100 and 300 mg/kg) and curcuminoid cider (1 and 2% v/v) inhibited the gene expression associated with lipid peroxidation.

Based on the findings, researchers wrote in the final report, "Oral administration of curcuminoid fraction and its cider product may exert potential inhibitory effects on oxidative stress related-genes for preventing hypercholesterolemia-induced atherosclerosis in vivo".

Taken altogether, turmeric processed a high amount of curcumin may be used for the prevention and treatment of abnormal blood lipid profile,, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials by Qin S1, Huang L1, Gong J1,2, Shen S1,2, Huang J1,2, Ren H2, Hu H. (PubMed)
(2) Efficacy of Oral Curcuminoid Fraction from Curcuma xanthorrhiza and Curcuminoid Cider in High-cholesterol Fed Rats by Mauren FM1, Yanti2, Lay BW. (PubMed)