Herbal Turmeric, the Natural Corticosteroids for the Treatment of Oral Lichen Planus

By Kyle J. Norton

Oral lichen planus is a  chronic inflammatory condition that affects mucous membranes inside the mouth.

Most common symptoms of oral lichen planus are white patches and red, swollen tissues, accompanied by pain and burning sensation that affect eating.

In some cases, patients with oral lichen planus also experience the symptoms of an open sore.

The condition is associated with the immune system that mistakenly attacks the cells of the oral mucous membranes for unknown reasons.

Most common area affected by being inside of the cheeks, gums,  tongue, particularly the inner tissues of the lips palate. Oral lichen planus is not contagious.

Conventionally, as of today, there is no cure for the condition. Most cases of oral lichen plants are treated by corticosteroids to reduce inflammation accompanied by the use of mouthwash, ointment or gel is applied directly to the mucous membrane.

In severe cases, autoimmune response medicine may also be used in patients to suppress or modify your body's immune response with an aim to improve more-severe lesions and lessen pain.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On findings a potential compound for the treatment of oral lichen planus, researchers examined the efficacy of curcumin in the treatment of the inflammation associated with mucous membranes inside the mouth.

By searching the database on the medical literature, four trials assessing the comparative efficacy of topical curcumin vs. topical corticosteroids and three trials assessing the efficacy of oral curcumin vs. placebo were identified and included in the review.

According to the results, topical curcumin exerted reductions in pain, burning, and clinical manifestations of OLP versus baseline, effects similar or inferior to topical corticosteroids.

However, oral administration of curcumin showed no significant benefits compared to placebo but provided some potential benefits and reasonable safety in an observational extension study.

In other words, topical curcumin displayed a clinical effect against oral lichen planus compared to only some benefits in oral curcumin injection with little or no side effects.

In order to reveal more information about curcumin anti oral lichen planus property, researchers examined the evidence for the safety of curcumin in treating OLP as well as its efficacy compared to that of corticosteroids.

The search of the database of PubMed, EMBASE, EBSCO, and Cochrane Library identified 9 studies met the inclusion criteria, including six randomized, double-blind clinical trials; two pilot clinical trials; and one case report.

In 259 OLP patients were included in the systematic review, researchers found that
* Curcumin showed statistically significant differences in pain severity and clinical appearance of oral 7 studies. for a period of time, compared to baseline.

* According to the results of 3 controlled clinical trials, curcumin exerted a significant effect on pain severity and clinical appearance of oral lesions similar to that of corticosteroids.

After taking others into account, Dr. Lv KJ, wrote in the final report, "Curcumin is a safe treatment and can be used as an adjunct in combination with corticosteroids to reduce pain, burning sensations, and the clinical appearance of oral lesions in OLP patients".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of oral lichen planus, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin, a turmeric extract, for oral lichen planus: A systematic review by White CM1,2, Chamberlin K1,3, Eisenberg E. (PubMed)
(2) Clinical safety and efficacy of curcumin use for oral lichen planus: a systematic review by Lv KJ1, Chen TC2, Wang GH1, Yao YN1, Yao H. (PubMed)