Herbal Turmeric Eradicates Pancreatic Cancer Cells

By Kyle J. Norton


The pancreas formed part of the digestive symptoms processed the function in secreting insulin and other important enzymes and hormones that help break down food.

In other words, the pancreas secretes pancreatic juice to the small intestine, that breaks down carbohydrates, proteins, and lipids and hormone insulin to convert glucose into energy for the needs of cell metabolism.

More precisely, exocrinally, pancreas promotes digestion and endocrinally, pancreas regulates blood glucose.

Traditional Chinese medicine view pancreas as a vital organ is responsible for the absorption of foods' qi and nutrients before passing them to nourish the body organs.

Pancreatic cancer is a condition characterized by abnormal cell growth in the tissue of the pancreas.

 Most cases of pancreatic cancers start in the ducts (an exocrine component of the pancreas) that carry pancreatic juices. The epithelium originated in glandular tissue accounts for over 75 - 90% of all cases of pancreatic cancer.

According to the statistics provided by the American Cancer Society, in 2019, estimated 56,770 American, including 29,940 men and 26,830 women will be diagnosed with pancreatic cancer. The disease also will cause of death of 45,750 people, including 23,800 men and 21,950 women.

Believe it or not, pancreatic cancer accounts for about 3% of all cancers in the US and about 7% of all cancer deaths.

Conventionally, treatment of the pancreatic cancer is totally depending on 

* The grade 

The Grades of pancreatic cancer are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise. 

* The stage such as localized, organ colonization, a distance of spreading and 

*  The size of the tumor

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential compound for the treatment of pancreatic cancer, researchers investigated the effects of curcumin and its analogs EF31 and UBS109 on pancreatic cancer (PC).

According to the tested assays in vitro, MIA PaCa-2 or PANC-1 cells exposed to curcumin and its analogs significantly impaired angiogenesis.

Furthermore, EF31 and UBS109 blocked the vascularization of subcutaneous matrigel plugs associated with pro-angiogenic molecules developed by MIA PaCa-2 in mice in vivo.

Additional examining the anti-angiogenesis of the EF31 and UBS109, researchers found that the inhibition of MIA PaCa-2 or PANC-1 cells was attributed to the significant inhibition of VEGF, angiopoietin 1, angiopoietin 2, platelet-derived growth factor,... involved in the formation of the new blood vessel.

Furthermore, EF31 and UBS109  also inhibited the growth of the tumor cells by inhibiting genes involved in the tumor growth, and anti-apoptosis.

Based on the findings, researchers said, " these results suggest that UBS109 and EF31 are potent curcumin analogs with antiangiogenic activities".

Moreover, the joint study led by the Guizhou People's Hospital also suggested that
* Curcumin inhibited cell growth, enhanced apoptosis, induced cell cycle arrest and retarded cell invasion in pancreatic cancer cells.

* The protein (Cdc20) associated with the interaction in cell cycle division was inhibited by the administration of curcumin in pancreatic cancer cells.

In other words, the overexpression of Cdc20 in enhancing cell proliferation and invasion, and abrogated the cytotoxic effects was significantly attenuated by curcumin in pancreatic cancer cells.

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of pancreatic cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antiangiogenic effects of a novel synthetic curcumin analogue in pancreatic cancer by Nagaraju GP1, Zhu S1, Ko JE1, Ashritha N1, Kandimalla R1, Snyder JP2, Shoji M1, El-Rayes BF. (PubMed)
(2) Inhibition of Cell Survival by Curcumin Is Associated with Downregulation of Cell Division
Cycle 20 (Cdc20) in Pancreatic Cancer Cells by Zhang Y1, Xue YB2, Li H3, Qiu D4, Wang ZW5, Tan SS6. (PubMed)
(3)
Pancreatic Cancer (Exocrine Cancers) by Kyle J, Norton