Bromelain Promotes Anti Inflammatory Activity Against Allergic Asthma

By Kyle J. Norton

Allergic asthma is the most common form of asthma, triggered by inhaling allergens such as dust mites, pet dander, pollen or mold.

The condition in most cases is involved in the overreaction of the immune system against the unharmful allergens, leading to the tightening the muscle of the airway.

Most common allergens facilitate the onset of allergic asthma include, pollen from trees, grasses, and weeds, mold spores, and fragments, animal dander.

Other conditions such as smoking, a fireplace, candles, incense, or fireworks, air pollution, chemical fumes are also found to induce allergic asthma in the US.

Most common symptoms of allergic asthma are coughing,  wheezing, shortness of breath and tight chest.

Severe allergic asthma can also cause complications such as hives, mouth or facial swelling, difficulty swallowing.

According to the Allergy and Asthma Network,  8.0 percent (19.1 million) of adults over age 18 in the U.S. have respiratory allergies, 8.4 percent (6.1 million) of children in the U.S. have respiratory allergies.

Conventionally, medications used for treating allergic asthma are focusing to reduce symptoms and improve quality of life.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a potential ingredient for the treatment of asthma, researchers examined the asthmatic protective of bromelain in C57BL/6J mice sensitized with OVA/alum and challenged with 7 days OVA aerosol.

Selected mice included in the study were received sBr 6 mg/kg/0.5 ml or PBS vehicle throughout sensitization.

According to the tested assays, sBr treatment throughout OVA-alum sensitization significantly reduced the development of allergic airway disease (AAD) by balancing the levels of BAL eosinophils and lymphocytes.

Furthermore, sBr decreased the levels of OVA-specific IgE and OVA TET(+) cells by inhibiting the elevated levels of CD11c(+) dendritic cell-associated with inflammation and CD44, a marker of inflammatory disease.

Based on the findings, researchers wrote, "These results provide additional insight into sBr's anti-inflammatory and antiallergic properties and rationale for translation into the clinical arena".

In order to reveal more information about bromelain anti-asthmatic symptoms, researchers investigated the ability of bromelain in reducing the inflammation of preexisting asthma via ovalbumin (OVA)-induced murine model of allergic airway disease (AAD).

Selected mice used in the study received either received phosphate buffered saline (PBS) only or bromelain in PBS as the intervention group.

According to the results at the end of the experiment, bromelain treatment of AAD mice (bromelain group) showed a significant anti-inflammatory activity observed by reduced BAL total leukocytes (P < .05), eosinophils (P < .05), and cellular infiltrates via lung pathology, compared to the control.

Bromelain also significantly reduced BAL CD4+ and CD8+ T cells, an indication of normal immune activity without affecting cell numbers in the spleen or hilar lymph node. 

In other words, bromelain inhibited allergic airway inflammation associated with the onset of asthma by inhibiting the production of pro-inflammatory cytokines through modulating the immune function.

Dr. Secor ER Jr, the leads scientist wrote, "The results suggest that bromelain has a therapeutic effect in established AAD, which may translate into an effective adjunctive therapy in patients with similar conditions, such as allergic asthma, who have chosen to initiate treatment after the onset of symptoms".

Taken altogether, bromelain may be considered supplements for the prevention and treatment of allergic asthma, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bromelain limits airway inflammation in an ovalbumin-induced murine model of established asthma by Secor ER Jr1, Shah SJ, Guernsey LA, Schramm CM, Thrall RS. (PubMed)
(2) Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells by Secor ER Jr1, Szczepanek SM2, Castater CA3, Adami AJ2, Matson AP4, Rafti ET4, Guernsey L2, Natarajan P2, McNamara JT5, Schramm CM4, Thrall RS2, Silbart LK. (PubMed)