Whole Food Onion Protects the Stomach Against Stomach Cancer

By Kyle J. Norton

Cancer is a class of chronic diseases associated with irregular cell growth in the tissues of the affected organ.

Stomach located between the esophagus and the small intestine is a muscular, hollow and an important organ of the digestive tract.

Stomach cancer is a medical condition characterized by abnormal growth of the mucus-producing cells of the inside lining of the stomach. 

Depending on the location of cancer that starts the malignancy, stomach cancer can be classified  into

* Adenocarcinoma arose from the glands in the mucosa, including
** Superficial spreading
It is an early stage of cancer and tends to be less aggressive.

** Polyploid
Cancer grows in a pattern like a polyp and is less aggressive.

** Infiltrating
If cancer grows in infiltrating pattern into the stomach wall and is more aggressive.

** Linitis plastica
Cancer grows diffusivity throughout the whole wall of the stomach.

Adenocarcinoma is the most common type of stomach cancer.

* Lymphomas
Cancer of the lymphocytes originated from the stomach behaves much like lymphomas of the other parts of the body but adenocarcinoma

* Sarcomas
Cancer originated from the connected tissue of the stomach behaves much like sarcomas of the other parts of the body but adenocarcinoma.

Most patients with stomach cancer in the early stage are asymptomatic. However,  at the later stage, patients may experience symptoms of pain and/or discomfort in the stomach area, mild ache in the upper part of the body, difficulty swallowing, feeling full or bloated after a small mealy, and vomiting blood or having blood in the stool accompanied by general symptoms shared by other types of cancer, including unintentional weight loss, loss of energy, tiredness, nausea, and vomiting and loss of appetite.

If you have some of the aforementioned symptoms, please check with your doctor to rule out the possibility.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the treatment of stomach cancer, researchers examined the chemopreventive effects of Allium vegetables (onions, garlic, shallots, leeks, chives, and so forth) on gastric cancer risk.

The study includes the research of MEDLINE studies of Allium vegetable consumption and gastric cancer published in any language, from January 1, 1966, to September 1, 2010.

19 case-control and 2 cohort studies, of 543,220 subjects. were selected in the analysis. Onion and other allium vegetable consumption of large amounts reduced the risk for gastric cancer with the odds ratio of 0.54 in the comparison of the highest and lowest consumption groups.

More precisely, an increment of 20 g/day of Allium vegetables consumed (approximately the average weight of 1 garlic bulb) showed a summary odds ratio for 0.91 based on case-control studies from the dose-response meta-analysis.

These results strongly suggested that regular consumption of onion have an inverse association with the risk of stomach cancer in a dose-dependent manner.

In other words, risk of stomach cancer was reduced proportionally to the amount of onion intake regularly.

Taken altogether, onion used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of stomach cancer, pending to the confirmation of the larger sample size and multicenter human study.

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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)
(2) Stomach Cancer/Gastric Cancer by Kyle J. Norton

Whole Food Cucumber Protects the Gut Microbiome Compostion Integrity

By Kyle J. Norton

Gut microbiome made up of the trillions of microorganisms is the bacterial composition found in the gut of the digestive tract.

In a healthy individual, the ratio of the bacterial composition is balanced. In other words, the bad bacteria in the digestive tract is totally countered by the presence of the good bacterias.

However, the imbalanced ratio of the composition of the gut microbiota has been associated with chronic diseases ranging from inflammatory bowel disease (IBD), obesity, and allergic disorders, in both human and animal models.

Believe it or not, gut microbes have been found to influence many aspects of human health including immune, metabolic, and neurobehavioural traits.

In immunity, balanced of the gut microbes showed to stimulate the immune function against inflammatory immune disorders.

Digestively, balanced gut microbes protect the gut against gastrointestinal diseases and non-gastrointestinal diseases.caused by overexpression of bad bacteria.

In metabolism, gut microbes influence what the human host is able to extract from its diet, such as nutrients, thus reducing the risk of obesity and obese complication.

Neurologically, gut microbiota can control brain insulin signaling and metabolite levels that play a critical role in neurobehaviors.

Some researchers suggested, there are huge benefits that influence the function of the brain, immunity, heart, and the digestive system and reduce the risk of chronic diseases and conditions such as diabetes and metabolic syndrome by maintaining the good ratio of the gut microbiome.

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to discover a natural ingredient for balancing the ratio of microbiota composition, researchers investigated evaluated cucumber phytochemical compositions along with their potential gut microbiota modulating, free radical scavenging, and anti-inflammatory capacities.

Seed flour extracts from cucumber enhanced total number of gut bacteria by altering the abundance of specific bacterial phylum or genus in vitro.

In other words, cucumbers improved the digestive functioning by enhancing the ratio of microbiota compositions in the gut.

Compared to broccoli and carrot seed flour extracts, cucumber seed extract showed the least effect in DPPH radical scavenging capacity, oxygen radical absorbing capacity, and hydrdoxyl radical (HO•) scavenging capacity values of 85, 634, and 270 μmol Trolox equivalent (TE)/g.

In the tested J774A.1 cells, cucumber suppressed the LPS induced production of pro-inflammatory cytokines.

The results strongly suggested that the administration of Cucumis prevented colonic inflammation and improved the digestive functioning by changing the gut microbiota composition.

In order to reveal more information of cumber in the improvement of gut microbiota, composition researchers examined Cucumis melo L. (Cucumis) on obesity-induced IR in genetically leptin-deficient Lepob/Lepob mice.

According to the tested assays, Cucumis improved IR and relieved inflammation in adipose tissue and blood that lead to the balance of the ratio of microbiota composition.

Dr. Lee D, the lead scientist after taking into account of co and confounders wrote, "administration of Cucumis improved IR by reducing inflammation, thereby changing the gut microbiota composition".

Taken altogether, fermented cucumber may be used for the treatment of digestive dysfunction by improving the ratio of gut microbiota composition, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Therapeutic Effect of Cucumis melo L. Extract on Insulin Resistance and the Gut Microbiome in Lepob/Lepob Mice by Lee D1, Yoo JH1, Lee BC. (PubMed)
(2) Chemical Compositions of Cold-Pressed Broccoli, Carrot, and Cucumber Seed Flours and Their in Vitro Gut Microbiota Modulatory, Anti-inflammatory, and Free Radical Scavenging Properties by Choe U1, Li Y1,2, Gao B2, Yu L1, Wang TTY, Sun J, Chen P, Liu J3, Yu L1. (PubMed)

Phytochemicals Lycopene Suppresses the Onset of Colorectal Cancer

By Kyle J. Norton

Colorectal cancer is a chronic condition caused cell growth irregularly in the tissue of colon and rectum. In other words, colorectal cancer includes colon and rectal cancer.

Colon and rectum formed parts of the digestive system with a function to reabsorb fluids and process and secrete waste products from the body.

Most cases of colorectal cancer start in the cells on the surface of the issue of either the colon or rectum. At the very early stage, due to the very small size of the tumor, colorectal cancer may not induce any symptoms.

However, at the advanced stage, the cancerous cells travel may travel a distance away from the colon and rectum to infect other healthy tissue and organ, leading to secondary metastasis.

According to statistics provided by WHO, colorectal cancer is the third most common cancer occurring in men and the second most commonly occurring cancer in women. Over 1.8 million new cases of colorectal cancer were diagnosed in 2018 worldwide.

Out of many prevalent factors associated with the risk of colorectal cancer, some researchers suggested that the rise of the incidence of the disease was linked to the promotion of the Western diet over the past few decades in the US and economic prosperity in South-East Asia.

More precisely, the increased colorectal cancer at an alarming rate is a result of replacing the traditional diet by the Western diet due to economic prosperity.

Dr. Alan Moss, the lead scientist wrote, "Dietary Patterns and Risk of Colorectal Cancer: Analysis by Tumor Location and Molecular Subtypes” by Mehta et al2 helps us to move beyond generalizations about Western diet and CRC risk, to a more detailed understanding of the association between diet and colorectal tumor location and also molecular subtypes".

And, "Processed meats result from salting, smoking, fermenting, or curing the meat, and common examples include ham, bacon, and sausage.5 Furthermore, red meat was declared as probably carcinogenic to humans, and red meat was listed as a group 2A substance.4 Red and processed meats are considered significant components of a “Western” diet".

Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.

With an aim to find a plant-based compound for the treatment of colorectal cancer (CRC), researchers examined the effect of lycopene in the risk of colorectal cancer developing.

The study was conducted by searching the studies published in the PubMed and EMBASE medical database.

According to 15 included in the meta-analysis,
* The comparison of summary relative risk (RR) for the highest versus lowest category, there was no significant association between lycopene consumption and the risk of colorectal cancer.

* However, lycopene consumption showed a significant effect in reducing the risk of colon cancer.

In other words, lycopene not only is associated with the risk of colorectal cancer but also is a phytochemical that process anti-colon cancer property. 

Additonally, according to the data on lycopene on HT-29 colorectal cancer cells and on animal models studies, injection of lycopene not only inhibited cell proliferation but also the progression of the CRC by interacting with various cellular signaling pathways, including proteins involved in pro-inflammatory production and cell death programming.

More precisely, lycopene suppresses colorectal cancer cells through its antioxidant activity.

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of colorectal cancer, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Lycopene Consumption and Risk of Colorectal Cancer: A Meta-Analysis of Observational Studies by Wang X1, Yang HH2, Liu Y3, Zhou Q4, Chen ZH. (PubMed)
(2) Colorectal cancer: an update on the effects of lycopene on tumor progression and cell proliferation by Carini F1, David S1, Tomasello G1,2, Mazzola M1,2, Damiani P3, Rappa F1,4, Battaglia L5, Gerges Geagea A1,6, Jurjus R7, Leone A. (PubMed)
(3) The Association Between Diet and Colorectal Cancer Risk: Moving Beyond Generalizations
Alan Moss, and Kumanan Nalankilli. (Gastroenterology)

Herbal Ashwagandha Inhibits the Onset of Breast Cancer Patients

By Kyle J. Norton

The breast formed part of the reproductive system consists of tissue overlying the chest (pectoral) muscles. In women, the breasts are made of produces milk (glandular tissue) and fatty tissue.

The size of women breast is totally depending on the amount of breast fatty tissue.

Depending on the menstrual stage induced by hormone expression, the breast ducts transport milk from the lobules out to the nipple.

In pregnancy, the changes to the breasts can start as early as 1 to 2 weeks after conception, leading to swelling or tenderness.

Breast cancer is a medical condition caused by the alternation of DNA of cells in the breast tissue.

According to the statistic, in 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.

Most cases of breast cancer start with cell growth disorderly on the surface of the inner lining of the breast tissue. At the later stage, malignant cells can infected other healthy cells and tissue far the way from the breast through fluids and blood circulation.

The exact causes of breast cancer are unknown. However, aging, reproductive history, dense breast, family and personal breast cancer history, particularly in women with the genetic preposition of  BRCA 1 and 2 are some of the most prevalent factors associated with the disease.

Women inherited the mutated gene BRCA 1 and 2 are associated with over 60% of breast cancer risk compared to women who do not.

Some researchers suggested the promotion of a high-fat diet-induced overweight and obesity over the past few decades may correlate to the increased incidence and motility of breast cancer in the US.

Dr. Carroll KK wrote, "High-fat diets are thought to increase the risk of breast cancer because animals develop mammary cancer more readily when they are fed high-fat compared to low-fat diets, and breast cancer incidence and mortality are higher in countries with high-fat as compared to those with low-fat diets".

And, "Studies on migrants have shown that breast cancer incidence and mortality increase in populations who move from countries with low-fat to those with high-fat diets, indicating that observed geographical differences in breast cancer are due to environmental rather than genetic factors".

These results strongly suggested the long-term high fat diet is associated with the increased risk of breast cancer.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

With an aim to find a potent compound for the treatment of symptoms associated the chemotherapy in breast cancer patients, researchers examined the Withania somnifera (Ashwagandha) anti side effects of chemo drug.

The open-label prospective nonrandomized comparative trial included a total of on 100 patients with breast cancer in all stages undergoing either a combination of chemotherapy with oral Withania somnifera at a dose of 2 g every 8 hours or chemotherapy alone.

Withania somnifera root extract was administered to patients in the study group throughout the course of chemotherapy.

According to the results, patients in the control arm or chemotherapy only treatment group experienced a statistically significant higher estimated marginal means of fatigue score compared to the study group.

Statistically, 7 out of 18 symptoms in the intervention group was significantly elevated in the control compared with the control group, according to the various symptom scales of the EORTC QLQ-C30.

More importantly, The 24-month overall survival for all stages in the study group was significantly higher at 72% compared to 56% of the control.

However, a median follow-up duration of 26 months.was not different in both groups. In other words, continued Withania somnifera root extract treatment may increase the survival rate of breast cancer patients in all stages.

Based on the findings, researchers said, "Withania somnifera has potential against cancer-related fatigue, in addition to improving the quality of life".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for reduction of chemo drugs side effects in breast cancer patients, pending to the result of larger sample size and multicenter study



Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You  How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients by Biswal BM1, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. (PubMed)
(2) An anti-cancerous protein fraction from Withania somnifera induces ROS-dependent mitochondria-mediated apoptosis in human MDA-MB-231 breast cancer cells by Dar PA1, Mir SA2, Bhat JA2, Hamid A3, Singh LR4, Malik F5, Dar TA. (PubMed)
(3) Dietary fat and breast cancer by Carroll KK. (PubMed)

Phytochemical Betacyanins Processes Cytotoxic Effect Against Cancer

By Kyle J. Norton

The cytotoxic effect is the process to kill cells through toxic substances, particularly in cancer cells.

Chemotherapy is a treatment that uses drugs to treat any disease, including cancer.

Chemo drug also has been used to shrink the tumor before surgery or combined radiotherapy to remove, kill, or damage cancer cells in a certain area, 

Chemo travel along the bloodstream to kill cancer cells throughout the whole body.

There are over 100 different types of chemo drugs, including
* Docetaxel (Taxotere), is a type of chemo drug used for the treatment of a chemotherapy drug. It is used to treat many types of cancer including breast, prostate, stomach, head and neck, and non-small cell lung cancer (NSCLC).

* Eribulin (Halaven) is used mostly for the treament of breast cancer by interfering with cancer cell division and growth.

* Ixabepilone (Ixempra) is used in patients with locally advanced or metastatic breast cancer.

* Paclitaxel (Taxol) has been used for the treatment of used to treat a number of types of cancers, including ovarian cancer, breast cancer, lung cancer, Kaposi sarcoma, cervical cancer, and pancreatic cancer.

* Vinblastine is most commonly used for the treatment of Hodgkin's lymphoma, non-small cell lung cancer, bladder cancer, brain cancer, melanoma, and testicular cancer.

Conventionally, chemo drugs have been found to induce serious side effects, including fatigue due to the loss of healthy cells, hair loss associated with the damage of hair follicles, easy bruising and bleeding, infection due to the weakened immune system, anemia is caused by the loss of red blood cells, digestive symptoms such as nausea and vomiting, appetite changes, and constipation.

Some of the symptoms may be going away as soon as the treatment stops. However, some symptoms  may take months or years after the treatment stops before disappearing

Betacyanins are phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, chard, etc.

On finding a natural compound for the treatment of cancer, researchers examined the extract of red beetroot (Beta vulgaris L.), the FDA approved red food color E162, cytotoxic effect.

Compared to the chemo drug doxorubicin (adriamycin), betanin, the major betacyanin constituent showed to exhibit a dose-dependent cytotoxic effect on human prostate cancer cells (PC-3) and in the well-established estrogen receptor-positive human breast cancer cells (MCF-7), comparable to those of doxorubicin.

In time analysis, although the cytotoxicity of the beetroot extract was significantly lower compared to doxorubicin which completely inhibits the growth of the PC-3 cells in three days, the extract continued to decrease the growth rate of the PC-3 cells (3.7% in 3 days vs. 12.5% in 7 days) at the concentration of 29 µg/ml.urthe

Furthermore, in the normal human skin FC and liver HC cell lines, the extract showed a significantly lower cytotoxic effect compared to doxorubicin (8.6% vs. 100%, respectively, at 29 µg/ml concentration of each, three-day test period). 

In chemical differentiation, the efficacy of beetroot extract was attributed to chemical compound betanin, the major betacyanin constituent in exerting the cytotoxicity.

Based on the finding, researchers said, "Further studies are needed to evaluate the chemopreventive potentials of the beetroot extract when used alone or in combination with doxorubicin to mitigate the toxic side-effects of the latter".

Taken altogether, betacyanins processed the major bioactive ingredient betanin may be considered a remedy for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of betacyanins in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cytotoxic effect of the red beetroot (Beta vulgaris L.) extract compared to doxorubicin (Adriamycin) in the human prostate (PC-3) and breast (MCF-7) cancercell lines by Kapadia GJ1, Azuine MA, Rao GS, Arai T, Iida A, Tokuda H. (PubMed)

Cranberry promotes postprandial blood glucose management

By Kyle J. Norton

Postprandial blood glucose is the range of blood glucose that is measured by the blood glucose test, taking after 2 hours of a meal.

At this point of measurement, postprandial blood glucose in a healthy individual usually gone back down. In other words, lower or equal to 7.8 mmol/L (140 mg/dL) 2 hours after eating are normal blood glucose found in a healthy individual.

Glycemic response is a change in blood glucose after consuming a carbohydrate-containing food compared to Glycemic Index (GI) that ranks carbohydrate-containing foods, according to their effect on blood glucose levels.

In other words, the glycemic response is the change of blood glucose after the intake of a food or meal.

More precisely, healthy people who are not prediabetes or diabetes have normal blood glucose and insulin levels that rise within the range after eating, then return to the fasting levels over a short period of time.

According to the 2015 statistics by the American Diabetes Association, in the U.S. over 30.3 million Americans or 9.4% of the population are living with diabetes. Sadly, out of 30.3 million adults with diabetes, 23.1 million were diagnosed, and 7.2 million were undiagnosed.

In 2015, 84.1 million Americans age 18 and older had prediabetes.

According to the epidemiological studies, by managing postprandial blood glucose effectively, diabetics can decrease the risk of microvascular (retinopathy, nephropathy, and neuropathy) and cardiovascular disease (CVD).

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of diabetes, researchers investigated the postprandial effects of dried cranberries following a high-fat breakfast challenge in obese participants with type 2 diabetes (T2DM).

The randomized crossover trial includes blood draw and vascular measurements such as fasting, 1, 2 and 4 hours (h), following the consumption of a fast-food style high-fat breakfast (70 g fat, 974 kcal) with or without cranberries (40 g).

According to the results of the analysis, biomarkers associated with inflammation and oxidative markers such as interleukin-18 and malondialdehyde were significantly lower at 4 h.

Serum total nitrite was found to be higher at 2 h in the cranberry compared to control group.

However, there were no significant differences levels of insulin, insulin resistance, lipid profiles and blood pressure between the cranberry and control group.

Furthermore, cranberries showed no effect on the levels of C-reactive protein or interleukin-6.

In other words, dietary cranberries inhibited the high-fat breakfast induced postprandial glucose and selected biomarkers of inflammation and oxidation in patients with T2DM without affecting other parameters associated with diabetes such as insulin, insulin resistance, lipid profiles, and blood pressure.

Based on the findings, researchers said, "adding whole cranberries to a high-fat meal may improve postprandial blood glucose management and warrant further investigation".

Taken altogether, cranberry may be considered a remedy used for the postprandial blood glucose management, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cranberries improve postprandial glucose excursions in type 2 diabetes buSchell J1, Betts NM, Foster M, Scofield RH, Basu A. (PubMed)
(2) Impact of Cranberry Juice Enriched with Omega-3 Fatty Acids Adjunct with Nonsurgical Periodontal Treatment on Metabolic Control and Periodontal Status in Type 2 Patients with Diabetes with Periodontal Disease by Zare Javid A1, Maghsoumi-Norouzabad L1,2,3, Ashrafzadeh E1,2,3, Yousefimanesh HA4, Zakerkish M5, Ahmadi Angali K6, Ravanbakhsh M2, Babaei H. (PubMed)

Bromelain, the Potential Prevention and Treatment of Flu Influenza

By Kyle J. Norton


Influenza A, B, C, and D are 4  types of flu influenza. Influenza virus A and B are seasonal flu occurred during the fall, winter and early spring, that causes sniffling, aching, coughing, and running and stuffy nose and fever, affecting over 20% of the general population.

Influenza virus types C in the virus family Orthomyxoviridae tends to cause mild upper respiratory infections, similar to those of cold.

Influenza D viruses only affect cattle.

Individuals who have influenza are usually recovered within one week and symptoms are gone within 2 weeks.

However, people with immature and weakened immune system including young children under age 5, adults older than age 65, elderly in nursing homes and other long-term care facilities, chronic illnesses, such as asthma, heart disease, kidney disease, liver disease and diabetes are not only associated with the risk of influenza but also increase the risk of influenza deadly complications.

Pregnant women and women up to two weeks postpartum due to change of the immune system are more prone to influenza and influenza complications.

Most common H and N subtype are influenza A that has been mutated to affect the combination of human, swine, and bird flu viruses, including

* H1N1 - Swine Flu

H1N1 normally is only transmitted among pigs. However, as of today, H1N1 became the first flu pandemic in the world that causes respiratory illness. 

* H5N1 - Bird Flu
H5N1 is the strain of influenza known as a bird or avian flu. Before, it is transmitted between birds, but today, it now can be passed from bird to human. The strain is dangerous to humans with high death rates.

Most common symptoms of influenza are high fever, runny nose, sore throat, muscle pains, headache, coughing, sneezing, and persistent fatigue.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

On finding a potential compound for the prevention and treatment of influenza, researchers compared the effect of two preparations of bromeline ("Sigma Co., Catalogues' Nos. B2252 and B5144).s

According to the tested assay, in influenza A(H1N1) virus, B5144 did not have any impact on it under similar experimental conditions. 

Furthermore, B5144 also showed an incomplete effect on influenza A(H3N2) virus with particles (with intact external coatings).

However, enzyme B2252 was effective for all viruses selected for testing, with the highest effect was noted for influenza A(H1N1) and B viruses.

In other words, not all bromelines are the same, some are more effective in the inhibition of viral influenza than the others.

Taken altogether, preparations of bromeline generation from bromelain may be considered a remedy for the prevention and treatment of influenza, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Generation of recombinant pandemic H1N1 influenza virus with the HA cleavable by bromelain and identification of the residues influencing HA bromelain cleavage by Wang W1, Suguitan AL Jr, Zengel J, Chen Z, Jin H. (PubMed)
(2) [The use of bromelain in obtaining the subviral particles of influenza A and B viruses].[Article in Russian] by Ivanova VT, Kordiukova LV, Manykin AA, Burtseva EI, Zagorskaia IuV, Oskerko TA, Slepushkin AN. (PubMed)

Herbal Turmeric Suppresses the Initiation and Progression of Breast Cancer

By Kyle J. Norton

The women breast is made up of specialized tissue that produces milk (glandular tissue) and fatty tissue. The size of the women breast is totally determined by the amount of fat.

Breast cancer is a medical and chronic condition associated with abnormal cell growth either in the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

Most cases of breast cancer start in the cells on the surface of the inner lining tissues of the breast before growing into a tumor by invading the deeper layers of the organ.

According to the statistics, the lifetime risk of invasive breast cancer developing is 12%.

In 2019, approximately 268,600 new cases of invasive breast cancer will be diagnosed in the U.S., along with 62,930 new cases of non-invasive (in situ) breast cancer.

The 5 years survival rate of breast cancer diagnosed at the early stage is closed to 100%.

Epidemiologically, there are several factors that can reduce the risk of breast cancer including
* Breastfeeding
Researchers found that women who breastfeed their babies slightly lower risk of developing breast cancer.

* Early age at first full-term pregnancy:
Women who have their first full-term pregnancy at an early age slightly lower the risk of developing breast cancer later in life.

* An increasing number of births
The risk of breast cancer declines with the birth of a number of children.

* Preeclampsia
Women who have had pregnancy conditions of high blood pressure and protein in the urine develop after the 20th week may slightly decrease the risk of developing breast cancer. 

*  Longer duration of breastfeeding:
Researchers found that breastfeeding for an extended period of over a year reduces the risk of developing breast cancer later in their life in both hormone receptor-positive and hormone receptor-negative breast cancer.

* Drinking more Coffee
In a new study, published in the journal Breast Cancer Research, women who drink five cups of coffee a day or more can reduce the risk of getting certain types of breast cancer. (How many women can do that without developing nervous tension).

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a potential compound for the treatment of breast cancers, researchers examined the chemoprevention effects of curcumin.

Based on the tested analysis, curcumin administration exerted its anticancer effect through a complicated molecular signaling network, involving proliferation, estrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2) pathways.

Curcumin injection also was found to regulate the gene expression associated with cancer cell apoptosis, cancer cell cycle arrests and microRNA expression in breast cancer cells.

Dr. Sinha D, the lead scientist in the investigation of the chemopreventive and chemotherapeutic potential of curcumin on breast cancer also suggested that

* Curcumin processed anti-breast cancer activity may be associated with its ability to influence a diverse range of molecular targets and signaling pathways as aforementioned.

* Combined with other chemo agents, curcumin enhanced the efficacy of existing chemotherapeutic advantage in vitro and in vivo models of breast cancer.

Based on the findings the doctor wrote, "The article also highlights recent developments with synthetic analogs of curcumin and nanocurcumin which are in the horizon of next-generation targeted therapy with curcumin in breast cancer".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of breast cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin in Treating Breast Cancer: A Review by Wang Y1,2, Yu J2, Cui R2, Lin J1, Ding X. (PubMed)
(2) Chemopreventive and chemotherapeutic potential of curcumin in breast cancer by Sinha D1, Biswas J, Sung B, Aggarwal BB, Bishayee A. (PubMed)
(3) Breast #Cancer by Kyle J. Norton

Healthy Food Navy Bean Balances the Ratio of Gut Microbiota for Optimal Health

By Kyle J. Norton

Gut microbiota a community of microorganisms that live in the gut of humans and animals. The gut metagenome contains genetic material recovered directly from environmental samples.

Depending on the genetic made up and environmental factors, including diet, the gut microbiota of one individual can be different compared to others

Epidemiological studies suggested that unbalanced of the ratio of bacterias in the GI tract induce changes in microbiome structure, that links to inflammatory, functional and metabolic disorders such as IBD, IBS, and obesity. 

Dr. Ana M Valdes, the lead scientist in the examined the health benefits associated with intestinal microbiome suggested that gut microbes have a strong effect on human health including immune, metabolic and neurobehavioral traits.

More precisely, the intestinal microbiomes

* Interact with the immune function that has a strong impact on host immune balance for optimal health.

In other words, intestinal microbiomes modulate the function of the immune system depending on the needs of the host.

* Reduce the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.

* Increase nutrient absorption from the diet and maintain digestive metabolism, thus reducing the risk of obesity and obese complications.

*  Control brain insulin signaling and metabolite levels against neurobehaviors.


The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to their numerous health benefits.

With an aim to find potential health food for the improvement of gut microbiota, researchers examined the impact of cooked navy bean powder on the fecal microbiome of healthy adult pet dogs.

The study included the analysis of the fecal samples from healthy dogs prior to dietary control and after 4 wk of dietary treatment with macro- and micronutrient matched diets containing either 0 or 25% cooked navy beans (n = 11 and n = 10, respectively).

According to the tested assay performed from the fecal samples, there were no major effects of navy bean inclusion on microbial populations. However, there were significant differences due to dietary intervention onto both research diets.

More precisely, after 4 wk of dietary intervention both control or navy bean diet, increased the levels of Phylum Firmicutes and decreased the levels of Phyla Actinobacteria and Fusobacteria, compared to baseline.

Additional differentiation of the sample, researchers suggest

* Cooked navy bean exerted no negative alterations of microbial populations in dogs, therefore, the bean powders may be a viable protein and fiber source for commercial pet foods.

* The no difference of both diet associated with the highly variable microbial populations observed in these healthy adult pet dogs at baseline may contribute to the potential reason for the difficulty to detect alterations in microbial populations following dietary changes.

Furthermore, in C57Bl/6 mice that were fed diets supplemented with 20% cooked navy bean (NB) or black bean (BB) flours or an isocaloric basal diet control (BD) for 3 weeks, researchers found that
* Both NB and BB diet similarly altered the fecal microbiota community structure by increasing the abundance of carbohydrate fermenting bacteria such as Prevotella, S24-7, and Ruminococcus flavefaciens.

* Both NB and BB enhanced mucus and epithelial barrier integrity vs. BD in multiple aspects associated with the diseases in the colon.

* The risk of colonic diseases involved in the biomarkers was also inhibited by both NB and BB diet through improving the colonic cell integrity.

Collectively, Dr. Monk JM, the lead scientist wrote, " Overall, NB and BB improved baseline colonic microenvironment function by altering the microbial community structure and activity and promoting colon barrier integrity and function; effects which may prove beneficial in attenuating gut-associated diseases".

Taken altogether, the fermented navy bean may be considered a remedy for the improvement of the gut microbiota, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of dietary cooked navy bean on the fecal microbiome of healthy companion dogs by Kerr KR1, Forster G, Dowd SE, Ryan EP, Swanson KS. (PubMed)
(2) Navy and black bean supplementation primes the colonic mucosal microenvironment to improve gut health by Monk JM1, Lepp D2, Wu W2, Pauls KP3, Robinson LE4, Power KA. (PubMed)

Healthy Food Onion Protects the Healthy Cell Against Cyto and Geno-Toxicity

By Kyle J. Norton

Cytotoxicity is the process that kills cells by inducing toxic substance.

Cancer cytotoxicity is the stage of killing cancer cells by toxicity with or without inducing side effects. 

Most cases of cytotoxicity of a substance are to determine the potential toxicity of the quality of the substance, including plant extracts or biologically active compounds isolated from plants.

In other words, the aim of the cytotoxic studies is to find the minimal quality that is essential for the successful development of pharmaceutical or cosmetic preparation that induces cellular toxicity for the treatment of cancer.

Before the preparation can be used in human, bioassays associated with a number of different cell lines in vitro and vivo have been used to assess the cytotoxicity of many herbal plants, including those of African medicinal plants. 

Free radicals have also been found to induce cytotoxicity to cause cancer death by oxidative stress.

Dr. Clifford Fong wrote, "An analysis of the cytotoxicity data for a wide range of anti-cancer drugs applied to triple negative breast cancer (TNBC) cells and ovarian cancer cells under normoxic, hypoxic and anoxic conditions have shown that free radical forms of the drugs are involved".

And " This finding is consistent with the known involvement of oxidative stress in the TNBC and ovarian cancer cells. A mechanism to explain the formation of these drug-free radicals and how they can be involved in oxidative stress is proposed".

Genotoxicity is the term associated with chemical agents that damages the genetic information within a cell, causing mutations of cell DNA, a major cause of cancer. 

Not all genotoxicity are mutagenicity, However, all mutagens are genotoxic.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the treatment of cancer, researchers examined the effect of an onion extract on cyto- and genotoxicity in human lymphocytes treated with bleomycin (BLM), a radiomimetic agent.

In radiation exposure -induced oxidative DNA damage in the increased risk of cancer, the risk the richest sources of dietary flavonoids found in onion inhibited the frequency of micronuclei (MN) and DNA damage following treatment with BLM, according to the cytokinesis-blocked micronucleus assay and a single cell gel electrophoresis assay. 

 Phytochemicals in the onion showed a significant increase in cell viability in lymphocytes exposed to BLM compared to cells treated with BLM alone.

Onion also suppressed the increased frequency of BLM induced MN and DNA damage in a dose-dependent manner evidenced by lymphocytes viability pretreated with onion extract (10 and 20 μL/mL).

Moreover, the frequency of BLM-induced MN was decreased at all doses of BLM and DNA damage was decreased by the administration at 3 μg/mL of BLM.

Based on the findings, researchers said, "onion extract may have protective effects against BLM-induced cyto- and genotoxicity in human lymphocytes".

Taken altogether, onion processed abundantly bioactive compounds may be considered a remedy for the prevention and treatment of cytotoxicity and genotoxicity, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective Effect of Onion Extract on Bleomycin-Induced Cytotoxicity and Genotoxicity in Human Lymphocytes by Cho YH1,2, Lee JW3, Woo HD4, Lee S5, Kim YJ6, Lee Y7, Shin S8, Joung H9, Chung HW. (PubMed)
(2) Evaluation of cytotoxicity and genotoxicity of Hancornia speciosa latex in Allium cepa root model by Ribeiro TP1, Sousa TR1, Arruda AS1, Peixoto N1, Gonçalves PJ2, Almeida LM. (PubMed)
(3) Free radicals in chemotherapy-induced cytotoxicity and oxidative stress in triple negative breast and ovarian cancers under hypoxic and normoxic conditions by Clifford Fong (HAL)

Herbal Turmeric Promotes the Disaggregation of Amyloid-β Plaques in Alzheimer's disease

By Kyle J. Norton

Dementia is a group of neurodegenerative diseases caused by a decline in mental ability in the older population that is severe enough to interfere with daily life, such as memory loss.

Compared to dementia, neurological disorders are a class of brain disease associated with reduced function of the brain, depending on the region of the neurons that were affected.

Alzheimer's disease is a type of dementia correlated with major reductions of neurons to the respective target areas, named after German physician Alois Alzheimer.

In other words, Alzheimer's disease is caused by the gradual loss of neuron functioning that usually starts with the early symptom of the difficulty of remembering recent events and worsens over time.

Alzheimer's destroys brain cells, causing cognitive modalities severe enough to affect language communication, memory, lifelong hobbies or social life. Alzheimer's gets worse over time, and it is fatal.

The disease is most prevalent in the elderly and causes over 60% of all cases of dementia.

According to the statistics, approximately 5.7 million Americans of all ages are living with Alzheimer's. 

Believe it or not, 15.9 million family caregivers provided an estimated 18.2 billion hours and $230 billion to people with dementia worldwide.

Epidemiological studies suggested that Alzheimer's disease is caused by a combination of genetic, lifestyle and environmental factors that affect the neurons of the brain over time. However,  less 10% of patients with AD are associated with a genetic preposition. Patients with such mutated genes on chromosomes 21, 14, and 1are virtually guaranteed to develop the disease.

Dr. Rudolph E. Tanzi said, "The inheritance of AD exhibits a dichotomous pattern. On one hand, rare mutations in APP, PSEN1, and PSEN2 virtually guarantee early-onset (<60 years) familial AD, which represents ∼5% of AD. On the other hand, common gene polymorphisms, such as the ε4 and ε2 variants of the APOE gene, can influence susceptibility for ∼50% of the common late-onset AD".

And, " These four genes account for 30%–50% of the inheritability of AD".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a natural compound which reduces the risk of Alzheimer's disease (AD), researchers examined the neuroprotective and cognitive-enhancing properties of turmeric in the prevention of Alzheimer's disease.

In vivo and vitro, curcumin, a polyphenol derived from turmeric herb exerted significant activity against the formation and promotes the disaggregation of amyloid-β plaques.

Furthermore, in hyperphosphorylation of tau, curcumin attenuated the saturation of multiple phosphorylation sites. Abnormal hyperphosphorylation of tau in the brain plays a vital role in the molecular pathogenesis of AD.

Moreover, curcumin enhanced the clearance of amyloid-β plaques aggregation by binding to the binds copper, lowering cholesterol.

Interestingly, curcumin also modified microglial activity against inflammation, inhibited acetylcholinesterase, the enzymes associated with reduced function neurotransmitters and mediated the insulin signaling pathway that augments neuronal growth and synaptogenesis associated with synapse formation.

Additionally, curcumin demonstrated a significant effect on neuro-stress through its antioxidant property.

Based on the finding, researchers wrote, "curcumin has the potential to be more efficacious than current treatments. However, its usefulness as a therapeutic agent may be hindered by its low bioavailability".

In other words, in order to overcome the curcumin limitation of bioavailability, the development of new curcumin formulations that increase bioavailability is necessary.

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of AD, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer's disease by Goozee KG1, Shah TM2, Sohrabi HR2, Rainey-Smith SR2, Brown B2, Verdile G2, Martins RN. (PubMed)
(2) The Mechanisms of Action of Curcumin in Alzheimer's Disease by Tang M1, Taghibiglou C. (PubMed)
(3) The Genetics of Alzheimer Disease by Rudolph E. Tanzi. (PMC)

Sulforaphane-Rich Broccoli Sprout Extracts Protects the Brain Cells Against Cognitive Deficits

By Kyle J. Norton

Cognition is the process of the brain functioning associated with the attention of working memory, producing and comprehending language, learning, reasoning, problem-solving, and decision making.

Cognitive deficit is a medical condition, that affects a person's thinking, communication, understanding or memory. The cognitive deficit can be acute or chronic.

Acute cognitive deficit is a short-term health problem caused by drugs toxicity and withdrawal, electrolyte disturbance, lack of drugs, liver disease, infection, reduced sensor input, intracranial urinary retention/fecal impaction or myocardial/metabolic/pulmonary. An acute cognitive deficit may be recovered if the cause is found.

Chronic cognitive deficit is a permanent medical condition caused by the gradual or permanent loss of the neurons, leading to problems of language, ideomotor and constructive praxis, visual gnosis, spatial attention, learning abilities, and executive functions.

There is no single cause of the chronic cognitive deficit.  Increase in age, genetic preposition, certain medical conditions, such as diabetes, high blood cholesterol, and pressure, being obese and lack of exercise are some prevalent factors found in patients with chronic cognitive deficit.

Some researchers suggested that depending on the locations of the brain that were affected, patients may be at risk of Alzheimer's disease such as brain change caused by the abnormal clumps of beta-amyloid protein (plaques).

Small strokes or reduced blood flow through the brain can also cause a chronic cognitive deficit.

According to the observation of the patient MRI, patients brain with cognitive impairment also showed shrinkage of the hippocampus, a brain region important for memory, enlargement of the brain's fluid-filled spaces (ventricles) and reduced use of glucose, the sugar that's the primary source of energy for cells.

Out of many risk factors associated with the onset of the condition, obesity is also one of the major risk factors of cognitive impairment in the Western world.

Dr. Jason C. D. Nguyen, the lead author on the neurological team wrote in the final report, "The incidence of obesity in middle age is increasing markedly, and in parallel, the prevalence of metabolic disorders including cardiovascular disease and type II diabetes is also rising. Numerous studies have demonstrated that both obesity and metabolic disorders are associated with poorer cognitive performance, cognitive decline, and dementia".

Brussels sprout is a species of wild cabbage (Brassica oleracea), belong to the family of Brassicaceae and was cultivated since ancient Rome.

With an aim to find a potential compound for the treament of cognitive impairment, researchers examined the effects of dietary intake of sulforaphane-rich broccoli sprout extracts against parameters associated with the risk of cognitive dysfunction in patients with schizophrenia.

According to the results of the experiment, sulforaphane (SFN) derived from broccoli showed a strong effect in the activation of the transcription factor Nrf2 regulated by Keap1, a cytoplasmic protein which plays a central role against the stimulation of oxidative stress.

Moreover, pretreatment with SFN attenuated cognitive deficit, the increase in 8-oxo-dG-positive cells, and the decrease in PV-positive cells in the medial prefrontal cortex and hippocampus found in patients with a neurodegenerative disease caused by oxidative stress induced by administration of phencyclidine (PCP).

In other words, PCP-induced cognitive deficits were inhibited by the subsequent subchronic administration of SFN. 

Believe it or not, chronic dietary intake of glucoraphanin (a glucosinolate precursor of SFN) during the juvenile and adolescence not only prevented the onset of PCP-induced cognitive deficit but also increased in 8-oxo-dG-positive cells and the decreased in PV-positive cells in the brain at adulthood.

The results strongly suggested the NRF2 gene and the KEAP1 gene had an epistatic effect in gene reaction on cognitive impairment (e.g., working memory and processing speed) in patients with schizophrenia.

Based on the findings, researchers said, "SFN may have prophylactic and therapeutic effects on cognitive impairment in schizophrenia. Therefore, the dietary intake of SFN-rich broccoli sprouts during the juvenile and adolescence may prevent the onset of psychosis at adulthood".

Taken altogether, broccoli sprout processed abundantly SFN may be considered a functional food for the promotion of cognitive deficit, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood by Shirai Y1, Fujita Y1, Hashimoto R2, Ohi K3, Yamamori H3, Yasuda Y3, Ishima T1, Suganuma H4, Ushida Y4, Takeda M3, Hashimoto K. (PubMed)
(2) Obesity and cognitive decline: role of inflammation and vascular changes by Jason C. D. Nguyen,1 A. Simon Killcross,2 and Trisha A. Jenkins. (PMC)

Cucumber's Cucurbitacin B (CuB) Might Process Anti Diabetes Potency

By Kyle J. Norton

Diabetes is a medical condition caused by not insufficient insulin entering the bloodstream.

In other words, diabetes is a condition associated with the inability of the body to use insulin properly.

Most cases of insulin insufficiency in the bloodstream in diabetes are either caused by the gradual died-off of the pancreas beta cells or insulin receptors clogged-up by fat and cholesterol.

Hallmarks of diabetes are hyperglycemia and insulin resistance.

According to the statistics, in 2017, 7.3% of Canadians aged 12 and older (roughly 2.3 million people) reported being diagnosed with diabetes

Most common causes of diabetes are

* Metabolic syndrome
Metabolic syndrome is a cluster of conditions including high blood pressure, cholesterol, and glucose

associated with an increased risk of diabetes.

* Gestational diabetes
High blood glucose of pregnant women has been found to increase the risk of diabetes in later life. 

* Prediabetes
Most cases of prediabetes are caused by unhealthy diets with high saturated fat, smoking, and excessive alcohol drinking. Prediabetes is a high-risk state for diabetes, especially in patients who remain with prediabetes despite intensive lifestyle intervention.

* Damage to the Pancreas causes the gradual and irreversible loss of beta cells that reduce the production of insulin

* Influenza a viruses
Influenza A virus is a common cause of pancreatitis in naturally and experimentally infected animals. 

However, recently, researchers found that influenza virus infection may play a role as a causative agent of pancreatitis and diabetes in humans.

* * Head trauma
Head trauma is considered a possible cause of central diabetes insipidus with symptoms of failure to concentrate urine, an increase in urine specific gravity.

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural compound which processes anti-diabetes property, researchers investigated the effect of different fractions of Cucumis prophetarum on antidiabetic and antioxidant activity.

The study was carried out to examine the anti-diabetes and antioxidants of the different doses of  aqueous crude extract (CE) of C. prophetarum fruits fractionated into water-soluble fraction 1 (F1), chloroform fraction 2 (F2), basic fraction 3 (F3), and neutral fraction 4 (F4) by acid-base extraction,

Based on the chemical analysis,
* F1 exhibited effective antidiabetic activity with an IC50 value of 20.6 and 59.9 µg/mL.

* According to α-amylase assay, the anti-diabetes activity was found in the decreasing order of CE > F4 > F3 > F2.

* According to the DPPH assay, F1 (IC50 = 73 µg/mL) showed better reducing ability than CE >F4 >F2 > F3 (IC50 = 78-272 µg/mL

* Furthermore, according to the SO and metal chelation assays, F1 showed the highest activity anti-diabetes at the IC50 = 101 and 147 µg/mL.

These results strongly suggested that F1 possesses a potent antidiabetic compared to other fractions,  in vitro.

In other words, all ingredients in cucumbers work synergistically to exhibit the anti-diabetes activity compared to a single compound.

Taken altogether, cucumber may be used for the treatment of diabetes, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antidiabetic and antioxidant potency evaluation of different fractions obtained from Cucumis prophetarum fruit by Gawli K1, Lakshmidevi N. (PubMed)
(2) Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling by Kim KH1,2, Lee IS1,2, Park JY1,2, Kim Y1,2, An EJ1,2, Jang HJ. (PubMed)
(3) Diabetes – The Causes by Kyle J. Norton

Healthy Food Navy Bean, a Natural Treatment of High Blood Cholesterol

By Kyle J. Norton

Cholesterol is a way substance produced by the liver or from food sources plays an important role to build strong cell membranes and produce steroid hormone and vitamin D and aiding the digestive tract in absorbing the nutrients for our body need.

Hyperlipidemia is also one of condition found in the cluster of metabolic syndrome.

In a healthy individual, excess cholesterol is returned to the liver after performing the aforementioned function by high-density lipoprotein or "good cholesterol".

However, a prolonged period of overexpression of abnormal blood cholesterol due to excessive consumption of fat or reduced levels of "good cholesterol" in the bloodstream can cause plaque building up on the arterial wall, leading to heart diseases and stroke.

Depending on the choice of diet, your risk of high blood cholesterol can be increased or decreased.

The healthy ratio of blood cholesterol is 4 (low-density lipoprotein) to 1 (high-density lipoprotein).

If your ratio is lower than 4, you are considered to have a healthy blood cholesterol ratio.

Hyperlipidemia is preventable. If you have high blood cholesterol, reducing bad fat intake accompanied by increased intake of "good cholesterol" with moderate exercise can be helpful.

More precisely, by changing to a healthy diet and lifestyle with moderate exercise, you are at the lower risk of high blood cholesterol sometimes in the future (weeks or months, depending on the levels of blood cholesterol today).

People who follow the Western diet with a high in saturated and trans fat, red meat, processed food and low in fruits and vegetables and whole grains may have a substantially increased risk of abnormally high blood cholesterol.

According to the article "Western Diet and Heart Risk", the author wrote, "Western diets cause a third of heart attack deaths worldwide,” the Daily Mail reports. Western-style diets high in meat, fat, dairy and salt put people at higher risk of a heart attack. According to the newspaper, a study has found that poor diet is responsible for 30% of the risk of heart disease".

The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to their numerous health benefits.

On finding a dietary source for the treatment of high blood cholesterol, researchers examined whether cooked navy bean powder (NBP) and/or heat-stabilized rice bran (RB) supplementation is tolerable, improves dietary fiber intake in children, and modulates lipid profiles.

The study included children aged 8 to 13 years at risk for CVD due to abnormal lipids. In other words, all participants were diagnosed with elevated cholesterol levels including total cholesterol ≥180 mg/dL and high-density lipoprotein (HDL) <60 mg/dL; low-density lipoprotein (LDL) ≥100 mg/dL and HDL <60 mg/dL; or non-HDL >100 mg/dL and HDL <60 mg/dL.

Participants received muffins or a smoothie daily that included 0 g NBP or RB (control), 17.5 g NBP, 15 g RB, or a combination 9 g NBP + 8 g RB. Fasting blood was collected at baseline and week 4.

Only 38 children completed the trial, including n = 9 control, n = 10 NBP, n = 9 RB, and n = 10 NBP + RB groups. 

Additionally, participants in the intervention groups significantly increased intake of NBP and RB at week 4 (p≤.01), particularly increased fibers in NBP and NBP + RB groups from baseline to week 4.

Based on the tested assays, HDL-cholesterol was higher in NBP-group participants compared to control at week 4.

Although other lipid parameters also showed signs of decreasing, they are insignificantly due to the

shorter duration in the experiment (4 weeks).

In other words, higher daily intakes are needed for a longer duration to induce favorable changes across multiple serum lipid parameters.

Taken altogether, navy bean may be considered a remedy for the prevention and treatment of high blood cholesterol, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A Pilot Randomized Controlled Clinical Trial to Assess Tolerance and Efficacy of Navy Bean and Rice Bran Supplementation for Lowering Cholesterol in Children by Borresen EC1, Jenkins-Puccetti N2, Schmitz K1, Brown DG1, Pollack A2, Fairbanks A1, Wdowik M1, Rao S1, Nelson TL1, Luckasen G3, Ryan EP. (PubMed)
(2) Western diet and heart risk, Tuesday, October 21, 2008, by NHS