Phytochemical 3,3'-Diindolylmethane Inhibits Parameters Associated with the Onset of Hyperglycemia

By Kyle J. Norton


Hyperglycemia is a condition of abnormally high blood sugar in the bloodstream associated with diabetic complications in patients with type 2 diabetes.

In order words, hyperglycemia is a result of the body which isn't properly using or doesn't make the hormone insulin.

Hyperglycemia is also considered a hallmark of patients with type 2 diabetes. Another hallmark is insulin resistance.

The condition occurs mostly due to poor control and management in patients with diabetes such as
a poor diet, physical inactivity choices, symptoms of medicines intake.

Some patients with diabetes also experience symptoms of hyperglycemia due to skipping not taking enough glucose-lowering medication.

Most common symptoms of hyperglycemia are frequent urination, increased thirst, blurred vision, persistent fatigue, and headache.

If you are having some of the aforementioned symptoms, you may have hyperglycemia. Please make sure you check with your doctor to prevent the longer-term untreated complications.

According to the epidemiological studies, untreated or long term persistently hyperglycemia in patients with diabetes has been found to induce serious symptoms such as shortness of breath,  confusion, and coma.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

With an aim to find a natural ingredient for the treatment of hyperglycemia in patients with type 2 diabetes, researchers examined the effect of the nutritive phytochemicals, indole-3-carbinol (I3C) and its metabolite, 3, 3'- diindolylmethane (DIM) on oxidative stress developed in type 2 diabetes mellitus (T2DM).

The study is carried out on the genetically modified mouse (C57BL/6J mice) similar to those of metabolic abnormalities of the human disease after the administration of a high-fat diet (HFD).

Injection of DIM and I3C positively modulated the glucose, insulin, and hemoglobin (Hb), glycated hemoglobin (HbA1c) level, an indication of the hyperglycemically modulatory activities in the tested HFD mice.

Compared to the HFD group, treatment groups showed a decrease in the levels of thiobarbituric acid reactive substances (TBARS), lipid hydroperoxides (LOOH), conjugated dienes (CD associated with oxidative stress in lipid peroxidation.

Futhermore, DIM and I3C also improved the antioxidant enzymes produced by the host observed by the increasing SOD, CAT, GPx levels in the erythrocyte, liver, kidney, and heart.

Levels of free radical scavengers such as vitamin C, vitamin E, and GSH levels are also increased in the plasma, liver, kidney, and heart in diabetic mice.

In other words, DIM and I3C protected diabetic mice against diabetics complications by modulating blood glucose and lipid by balancing the ratio of free radicals and antioxidant in the tested subjects.

Based on the finding, researchers wrote in the final report, "the antioxidant-scavenging action was accelerated in mice treated with DIM than the I3C treatment group which was comparable with the standard drug metformin".

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of hyperglycemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Attenuation of hyperglycemia-mediated oxidative stress by indole-3-carbinol and its metabolite 3, 3'- diindolylmethane in C57BL/6J mice by Jayakumar P1, Pugalendi KV, Sankaran M. (PubMed)