Liver toxicity or hepatotoxicity is a condition that the liver is damaged by chemical substances, including drug-induced liver injury is a cause of acute and chronic liver disease.
The liver is the largest internal organ not only processes the function in filtering the blood coming from the intestine before passing them to other parts of the body but also secretes bile that aids the function of digestive system in digest food, build strong cell membranes, production of vitamin D and steroid hormones.
Symptoms of liver toxicity may include stomach pain, upset stomach, persistent tiredness, dark-colored urine but light-colored bowel movements, particularly in the expression of jaundice found in the skin and eyes.
Other researchers suggested that psychological symptoms such as stress, anxiety and depression are also found in patients with liver toxicity.
Most common causes of liver toxicity are associated with drugs.
According to critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one case report of convincing reports of liver injury and 48 drugs had more than 50 case reports.
Believe it or not, amoxicillin-clavulanate has been found to induce liver toxicity in approximately one out of 2300 users.
However, according to the study published by the Journal of Phytopharmacology, live toxicity can also be caused by interruption of the liver function in metabolizing substances.
Dr. Meagan Thompson, the lead scientist wrote, " The human liver metabolizes substances via oxidation, reduction, hydration, hydrolysis, condensation, conjugation, or isomerization. Interruption of these processes can lead to hepatotoxicity, causing liver cancer, cirrhosis, and Hepatitis C, respectively".
And "Such diseases are responsible for higher mortality rates worldwide. The present review focuses on highlighting various plants that are hepatoprotective, hepatotoxic and the challenges faced by phytopharmaceuticals".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
On finding a natural compound for the treatment of liver toxicity scientists evaluated the therapeutic potential of Curcuma longa (200mgkg-1, po) and curcumin (80mgkg-1, po) for their hepatoprotective efficacy against mercuric chloride (HgCl2: 12μmolkg-1, ip; once only) hepatotoxicity.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of liver toxicity scientists evaluated the therapeutic potential of Curcuma longa (200mgkg-1, po) and curcumin (80mgkg-1, po) for their hepatoprotective efficacy against mercuric chloride (HgCl2: 12μmolkg-1, ip; once only) hepatotoxicity.
Dr. Mohamad RH, the lead scientist said, "The present findings conclude that the turmeric extract has multiple therapeutic activities that block the hepatic....toxicities".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of liver toxicity, pending to the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcuma longa Linn. extract and curcumin protect CYP 2E1 enzymatic activity against mercuric chloride-induced hepatotoxicity and oxidative stress: A protective approach by Joshi D1, Mittal DK2, Shukla S2, Srivastav SK3, Dixit VA. (PubMed)
(2)The role of Curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats by Mohamad RH1, El-Bastawesy AM, Zekry ZK, Al-Mehdar HA, Al-Said MG, Aly SS, Sharawy SM, El-Merzabani MM. (PubMed)
(3) Hepatotoxicity by Drugs: The Most Common Implicated Agents by Einar S. Björnsson. (PMC)
(4) Hepatotoxicity: Treatment, causes and applications of medicinal plants as therapeutic agents by Meagan Thompson, Yogini Jaiswal, Ilya Wang, Leonard Williams( the Journal of Phytopharmacology)
(3) Hepatotoxicity by Drugs: The Most Common Implicated Agents by Einar S. Björnsson. (PMC)
(4) Hepatotoxicity: Treatment, causes and applications of medicinal plants as therapeutic agents by Meagan Thompson, Yogini Jaiswal, Ilya Wang, Leonard Williams( the Journal of Phytopharmacology)
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