Phytochemical Sinigrin Protects Our Body Against Chronic Inflammatory Diseases, According to PubMed

By Kyle J. Norton

Scientists may have found a bioactive ingredient for the treatment of diseases associated with chronic inflammation, according to studies.

Inflammation is a natural process of the immune system which tries to protect our body against the invasion of stimuli and pathogens.

This process has been found to involve several stages after the bodily injury caused by physical impact or internal damage.

In the acute phase of infection, the white blood cells of the first line of immune defense stimulate to the production of blood coagulation to cover the wound and activate the protein associated with the production of inflammatory cytokines to kill off the invaders before they can enter the body.

However, overproduction of proinflammatory cytokines can lead to damage and death of the healthy cells, causing the irreversible scars as in liver hepatitis infection.

Chronic inflammation (CI) is a result in which the immune system can not destroy the invasive pathogens in the acute phase of infection within 3- 8 weeks, leading to the immune adaptation of the new change in facilitating low-grade inflammatory diseases, including arthritis and diabetes.

Out of a number of factors involved the onset of chronic inflammatory, some researchers suggested that the immune system dysfunction is one of the most prevalent risk factors in CI.

Dr. MARK HYMAN, MD in the article of inflammation & immune balance wrote, "If your immune system and your ability to balance the inflammatory forces in your body are impaired, watch out. You are headed toward illness and premature aging".

Sinigrin is a phytochemical glucosinolate, belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.

Scientists on searching the natural alternative compound with anti-inflammatory activity examined the sinigrin effects on adipogenesis in 3T3-L1 preadipocytes.

Injection of sinigrin remarkably inhibited the accumulation of lipid droplets and the process of cell differentiation associated with inflammation by inhibiting the expression of a protein involved key activators of adipogenesis, the CCAAT-enhancer-binding protein α (C/EBPα).

Furthermore, sinigrin also decreased the expression of peroxisome proliferator-activated receptor gamma (PPARγ), which plays in regulating adipogenesis, lipid metabolism, cell proliferation, inflammation, hormone leptin in the promotion of inflammation and the expansion of effector T cells (Teff) and the fatty acid-binding protein, aP2 coordinated with inflammatory activity.

Moreover, sinigrin arrested cells in the G0/G1 phase of the cell cycle against inflammation in the induction of cellular damage.

Additionally, sinigrin also increased the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK), in reducing the immune inflammatory responses. mitogen-activated protein kinase (MAPK) and acetyl-CoA carboxylase (ACC) in regulating the fatty acid synthesis and degradation, in the early stage of adipocyte differentiation in adipocytes inflammation.

The anti proinflammation of sinigrin inhibition also are observed by limiting the production of pro-inflammatory cytokines including tumor necrosis factor -alpha (TNF-α) and interleukin (IL)-6, IL-1β and IL-18.

Dr. Lee HW and colleagues wrote in the final report, "sinigrin inhibits early-stage adipogenesis of 3T3-L1 adipocytes through the AMPK and MAPK signaling pathways".

The findings strongly suggested that sinigrin exerted a significant anti-inflammatory activity via several proteins and pathways.

Taken altogether, sinigrin may be considered a supplement for the prevention and combined with primary medicine for the treatment of diseases associated with chronic inflammation.

However, intake of supplement should be taken with exceptional care to prevent liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibitory effect of sinigrin on adipocyte differentiation in 3T3-L1 cells: Involvement of AMPK and MAPK pathways by Lee HW1, Rhee DK1, Kim BO2, Pyo S. (PubMed)
(2) UltraWellness Lesson 2: Inflammation & Immune Balance by Dr. MARK HYMAN, MD