3,3'-Diindolylmethane, May Be Potent Against Glioblastoma, Scientists Say

By Kyle J. Norton

Scientists may have found a bioactive ingredient for the treatment of glioblastoma (GBM) and resistant glioblastoma with no side effects, according to studies.

Glioblastoma is one of the most aggressive cancers that begins within the brain.

According to statistics,  most patients diagnosed with cancer die within 12 to 15 months. Less than 5% of patients is survived longer than five years.

If you are male you are at 1.5 higher risks of glioblastoma, compared to the female's counterpart.

The causes of glioblastoma are unknown, some researchers suggested that genetic preposition and environmental factors, previous radiotherapy, a weakened immune system may be some risk factors associated with the onset of the disease.

Most cases of GBM are diagnosed at an older age with a median age of 64. Some researchers suggested that aging with the change of body function may be one of the major risk factors that causes the incidence.

Dr. Judith Schwartzbaum, an associate professor of epidemiology and a member of The Ohio State University’s Comprehensive Cancer Center, in the study focused on the relationship between chemical signals from the immune system and the development of brain cancer uncovered the relationship between allergies, the immune system, and brain cancer. It appears that allergies may protect against the development of brain cancer.

She wrote, "It's important to identify the early stages of tumor development if we hope to intervene more effectively. " and "If you understand those early steps, maybe you can design treatments to block further tumor growth".

The results strongly suggested that people with a weakened immune system such as the elderly may be at a higher risk of glioblastoma

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

Researchers in the concern of current therapy deficits for treatment glioblastoma due to the limitation of limits the transport of essential drugs to the tumor sites. examined the effects of 3,3'-diindolylmethane by encapsulation in poly (lactic-co-glycolic acid) nanoparticles.

Nanoformulation loading of 27-87nm and encapsulation efficiency of 7.2% and 70% respectively showed to induce the glioma cells apoptosis internally.

Furthermore, in vivo, a bio-distribution study revealed the selective accumulation of the nanoformulation into rat brain tumor sites by crossing the blood-brain barrier.

Moreover, the nanoformulation also exhibited the abrogation of epidermal growth factor receptor pathway which has been found to that promote the growth and spread of glioblastoma cells.

Dr. Bhowmik A, the lead scientist after taking into account co and confounders, wrote, "Our novel nano preparation, therefore, shows great promise to serve as a template for targeted delivery of other therapeutics in treating GBM".

In order to reveal more information about the prognosis for glioblastoma patients, researchers examined the 3,3'-diindolylmethane anti glioblastoma activity.

Indole-3-carbinol and related fragments, including 3,3'-Diindolylmethane exerted a potent anti glioblastoma activity with low micromolar activity, particularly resistant glioblastoma cell culture.

The finding clearly suggested that 3,3'-diindolylmethane alone or encapsulated in poly (lactic-co-glycolic acid) nanoparticles induced the glioblastoma cells and resistant glioblastoma cells death through a number of mechanisms.

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and combined with primary medicine for the treatment of glioblastoma and resistant glioblastoma, pending to the confirmation of the larger sample size and multicenter human study.

Intake of 3,3'-diindolylmethane in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells by Sherer C1, Tolaymat I2, Rowther F3, Warr T3, Snape TJ. (PubMed)
(2) Anti-SSTR2 peptide based targeted delivery of potent PLGA encapsulated 3,3'-diindolylmethane nanoparticles through blood brain barrier prevents glioma progression by Bhowmik A1, Chakravarti S1, Ghosh A2, Shaw R1, Bhandary S2, Bhattacharyya S3, Sen PC2, Ghosh MK. (PubMed)
(3) Immune System Research May Help Brain Tumor Diagnosis by Health Line