Ginger, the Natural Antibiotics Alternative Functional Spice

By Kyle J. Norton

Ginger may be considered a natural antibiotics alternative for the treatment of Candida albicans overgrowth without inducing any side effects, some scientists suggested.

Candida albicans is an opportunistic pathogenic yeast formed part of the commensal gastrointestinal mycobiota.

Candida albicans overgrowth is the most prevalent cause of fungal infections in human.

Epidemiological studies strongly suggested that long-term users of antibiotics that cause an imbalance of the gut microbiome, weakened the immune system, unhealthy diet, and women who are pregnant and hormone imbalance of hormone near menstruation are susceptible to the onset of the condition.

If you experience symptoms of oral thrush, recurring genital or urinary tract infections, persistently digestive issues, joint pain. particularly, in the skin and nail fungal infections, you may have a yeast infection.

Please check with your doctor to rule the Candida albicans overgrowth possibility.

Dr. Carol A. Kumamoto in the research team of infectious diseases in the study "Inflammation and gastrointestinal Candida colonization" suggested that a Candida albicans overgrowth can be caused by other medical conditions, associated to a digestive disorder.

In the study, the doctor wrote, "Recent studies, however, show that high-level Candida colonization is associated with several diseases of the gastrointestinal tract. Further, results from animal models argue that Candida colonization delays healing of inflammatory lesions and that inflammation promotes colonization".

And, "Both inflammatory bowel disease and gastrointestinal Candida colonization are associated with elevated levels of the pro-inflammatory cytokine IL-17. Therefore, effects on IL-17 levels may underlie the ability of Candida colonization to enhance inflammation".

These results strongly suggested, inflammation flames the overgrowth of Candida colonization in return, the overgrowth of Candida albicans induces persistently low-grade inflammation.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find the natural ingredient or whole food for the replacement of the conventional antibiotics without inducing any effects, researchers at the Teikyo University Institute of Medical Mycology, investigated the effect of ginger against infection caused by Candida albicans.

 4 preparations of the essential oils of young and mature rhizomes, air-dried and steamed rhizomes, and seed rhizomes of Zingiber officinale Roscoe (ginger) were compared in the study.

* All ginger essential oils processed a significant anti-Candida albicans activity.

* Essential oil from the seed and air-dried rhizomes, exerted the highest effect compared to other preparations.

* The seed and air-dried rhizomes essential oils also had a potent inhibitory activity compared to ginger oleoresins obtained by ethanol and hypercritical carbon dioxide extraction and essential oils of 5 other plants in the family Zingiberaceae.

According to the chemical constituents assay, [6]-shogaol was most active against filament formation and growth of C. albicans, followed by citral and [6]-gingerol.

Futhermore, ginger oleoresin, especially that obtained by ethanol extraction, with a high [6]-gingerol content exhibited potent anti the growth of C. albicans compared to essential oils of ginger and other Zingiberaceae plants.

Moreover, a vitro joint study by the Institute of Science and Technology, researchers launched an investigation to evaluate the antimicrobial activity of 2% chlorhexidine gel (CHX) isolated from the ginger as auxiliary chemical substance and intracanal medications on Candida albicans.

The study included 48 single-rooted human teeth randomly divided into fourr groups (n = 12), according to intracanal medications used: (1) Calcium hydroxide + apyrogenic saline solution (Ca(OH)2 + SS), (2) 20% ginger glycolic extract (GEN), (3) calcium hydroxide + 20% ginger glycolic extract (Ca(OH)2 + GEN), (4) apyrogenic SS (control). 

At the end of the experiment, researchers found that

* CHX was effective in the complete elimination of E. coli and C. albicans.

* ChX also significantly reduced and then completely eliminated E. faecalis after intracanal medication.

* All other applications also revealed a reduction of endotoxins, the outer membrane of the cell wall of Gram-negative bacteria.

In the final report, the research team concluded, "CHX and intracanal medication used were able to eliminate the microorganisms from the root canal; the endotoxins were reduced, yet not completely eliminated".

These result strongly suggested that ginger bioactive compound processes a significant antibacterial activity, particularly in those of C. albicans.

Taken altogether, there is no doubt that ginger may be considered a functional food for the prevention and combined with primary medicine for the treatment of yeast infection with no side effects.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-Candida and radical scavenging activities of essential oils and oleoresins of Zingiber officinale Roscoe and essential oils of other plants belonging to the family Zingiberaceae by Takahashi M1, Inouye S, Abe S.(PubMed)
(2) Action of Chlorhexidine, Zingiber officinale, and Calcium Hydroxide on Candidaalbicans, Enterococcus faecalis, Escherichia coli, and Endotoxin in the Root Canals by Valera MC1, Oliveira SA2, Maekawa LE2, Cardoso FG3, Chung A2, Silva SF2, Carvalho CA2. (PubMed)
(3) Inflammation and gastrointestinal Candida colonization by Carol A. Kumamoto. (PMC)