Ginger Kills Retinoblastoma Cancer Cells

By Kyle J. Norton

Scientists may have a pungent spice which processes a potential to treat retinoblastoma, according to studies.

Retinoblastoma (Rb) is a rare form of cancer rapidly developed due to the production of the immature cells of a retina. Retina, composed many layers, is the sensory membrane that lines the inner surface of the back of the eyeball. Most cases of retinoblastoma (Rb) are found in young children.

According to the statistics, provided by the American Cancer Society, approximately 200 to 300 children are diagnosed with retinoblastoma each year in the United States. The average age of children affected by retinoblastoma is 2. The disease rarely occurs in children older than 6.

Retinoblastoma diagnosed at the early stage is curable. However, the advanced form of retinoblastoma can be life-threatening.

Epidemiological studies suggested that age and genetic preposition are the 2 most common risk factors associated with the onset of retinoblastoma. 

Some researchers suggested that children inherited gene Rb may be associated with the risk of retinoblastoma development.

Dr. Jun Yun and colleagues in examing the epidemiology and Rb1 gene of retinoblastoma said, "Retinoblastoma (Rb) is the most common eye cancer in children and it can be inherited". 

And, "In children with the heritable genetic form of Rb, there is a mutation on chromosome 13, called the retinoblastoma 1 (Rb1) gene. Early diagnosis and intervention are critical to the successful treatment of the Rb."

The results strongly suggested that the mutation gene Rb1prevents the protein to carry the function as a negative regulator of the cell cycle, leading to the unbalance between cell growth and development, a major cause of retinoblastoma.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Scientists may have found a natural ingredient for the treatment of retinoblastoma with no side effects by examing the gingerol anti-cancer activity on retinoblastoma cancer cells (RB355 Cell Line).

Application of gingerol exerted dose-dependent and time-dependent growth inhibitory effects against the retinoblastoma cells. 

The growth inhibitory effects of gingerol were less pronounced against normal fr2 cells. In other words, ginger application inhibited the growth of retinoblastoma cells without affecting the normal epithelial fr2 cells.

Compared to the untreated control cells, gingerol-treated cells at concentrations of 25, 75, and 150 μM had drastic changes in cell morphology, including rounding and withering of cells, with disorganized cell layers, the indications of rupture of the cell membrane and cellular damage.

Furthermore, untreated cells showed normal green fluorescence and gingerol-treated cells showed yellow/red fluorescence captured and classified by the image test.

Moreover, gingerol also displayed an inhibitory activity at a dose-dependent in the G2/M phase cell cycle arrest on RB355 retinoblastoma cells.

In-depth analysis, researchers found that the kitchen spice at concentration-dependent also inhibits the protein expressions involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival, and intracellular trafficking,

Dr. Bo Meng and colleagues wrote in the final report, "Gingerol exhibits potent anticancer effects in RB355 human retinoblastoma cancer cells and these effects were mediated via apoptosis induction, cell cycle arrest, and modulation of the PI3K/Akt signaling pathway".

Where PI3K/Akt signaling pathway is an intracellular signaling pathway associated with the cell division cycle.

Taken altogether, ginger processed abundantly bioactive compound gingerol may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of retinoblastoma, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Anticancer Effects of Gingerol in Retinoblastoma Cancer Cells (RB355 Cell Line) Are Mediated via Apoptosis Induction, Cell Cycle Arrest and Upregulation of PI3K/Akt Signaling Pathway by Bo Meng,1,B,D Hongyi Ii,2,B,D,E Wei Qu,1,C,D,E and Huiping Yuan1,A,C,G. (PMC)
(2) Epidemiology and Rb1 gene of retinoblastoma by Jun Yun,1 Yang Li,2 Chang-Tai Xu,3 and Bo-Rong Pan. (PMC)