Holistic Health Articles and Research Related to Herbal Medicines, Foods and Phytochemicals : January 2019

Thursday, 31 January 2019

Allyl isothiocyanate, the Potential Anti Liver Cancer Bioactive Ingredient

By Kyle J. Norton

Scientists may have discovered a bioactive compound isolated from horseradish for the prevention and treatment of liver cancer, according to the studies.

Liver cancer is a medical condition caused by irregular cell growth in the liver. Most cases of primary liver cancer start in the cells on the surface of the inner lining of the liver. At the early stage of liver cancer, the patient may not experience any symptoms.

However, at the later stage, the overgrowth of tumor in the liver may suppress the nearby tissue and nerve cells, leading to localized symptoms and severe pain.

According to the world standard statistics, the onset of liver cancer rate is 10.1 per 100,000 people (15.3 in males and 5.3 in females).

The highest mortality rates occurred observed in the East Asian countries probably due to the high incidence of hepatitis virus.

The world standardized mortality rate for liver cancer is 9.5 per 100,000 people (14.3 in males and 5.1 in females).

The most common risk factor of liver cancer is associated with the hepatitis viral infection. People with chronic infection with HBV or HCV are found in the high percentage of patients with liver cancer.

Dr. Marc Ringehan, in the concern of the high percentage of hepatitis viral carriers in the risk of liver cancer said, "Hepatitis B and C viruses are a global health problem causing acute and chronic infections that can lead to liver cirrhosis and hepatocellular carcinoma (HCC)" and "Owing to its high incidence and resistance to treatment, liver cancer is the second leading cause of cancer-related death worldwide, with HCC representing approximately 90% of all primary liver cancer cases".

" (Particularly, hepatitis B virus infection can promote HCC development without prior end-stage liver disease".

These results clearly reaffirmed the risk of liver cancer in population carrying the hepatitis B and C.

In fact, people who are chronically infected with hepatitis B have a 25% to 40% lifetime risk of developing liver cancer.

Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.

With an aim to find a natural compound for the prevention and treatment of liver cancer, researchers looked into Allyl isothiocyanate (AITC), a bioactive ingredient and N-acetylcysteine (NAC) conjugate anti-liver cancer effects through the SK-Hep1 cells line.

Application of AITC exerted a significant activity in the inhibition of genes and proteins associated with suppressing tumor cell migration and activating cytokines and chemokines to regulate tissue remodeling.

At 25% for 10 micros, AITC suppressed SK-Hep 1 cell proliferation in a dose-dependent manner.

At 0.1-5 microM, AITC inhibited a significant MMP-2/-9 expression in SK-Hep1 cells compared with controls associated with the decrease of MMP-2/-9 messenger RNA levels.

However, AITC inhibited cancer cell adhesion and invasion much less potently compared to NAC-AITC.

Dr. Hwang ES and colleagues at the Seoul National University, said, "NAC-AITC at 5 microM caused excellent inhibition of cell migration for 48 hrs. These results demonstrate the potential of AITC and NAC-AITC as chemopreventive agents".

Taken altogether, Phytochemical Allyl isothiocyanate may be used for the prevention and treatment of liver cancer, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Allyl isothiocyanate influences cell adhesion, migration and metalloproteinase gene expression in SK-Hep1 cells by Hwang ES1, Kim GH. (PubMed)
(2) Allyl isothiocyanate and its N-acetylcysteine conjugate suppress metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in SK-Hep 1 human hepatoma cells by Hwang ES1, Lee HJ. (PubMed)
(3) Viral hepatitis and liver cancer by Marc Ringehan,1,2,3 Jane A. McKeating,4,5 and Ulrike Protzer. (PMC)

Phytochemical Sulforaphane (Dithiolthiones) Kills Cervical Cancer Cells, According to Studies

By Kyle J. Norton

Scientists may have found a bioactive compound isolated from cruciferous vegetables for the prevention and treatment of cervical cancer with no side effects, according to studies.

The cervix is an opening passage in the center of the ectocervix, that connects the uterus to the vagina in female reproductive organs. Cervix acts as a transition area for vaginal lining (squamous epithelium) change to uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus.

Cervical cancer is a medical condition caused by irregular and disordered cell growth in the tissue of the cervix.

Most cases of cervical cancer start in the cells on the surface of the inner lining the cervix. At the early stage, most patients do not experience any symptoms.

However, at the later stage, the overgrowth tumor may suppress the nearby blood vessels and nerve tissue, leading abnormal bleeding and severe abdominal pain.

At this stage, cancerous cells from cervix also can travel a distance away to infect other healthy tissue and organ, through lymph and blood circulation, causing the secondary metastasis.

Most common cervical metastasis includes the vagina, the uterus, the uterus, the tissue nearby lymph nodes in the pelvis, back of the abdomen tissue and ligaments around the cervix and uterus

According to the statistic, cervical cancer is most often diagnosed between the ages of 35 and 44 and only 15% of cervical cancers are diagnosed in women over age 65.

The five years survival rate of invasive cervical cancer is 92% if diagnosed in the early stages.

What causes cervical cells DNA alternation? Researchers do not know. But researchers do know that immune system deficiency, smoking, the increase in age, long-term use of oral contraceptives and exposure to diethylstilbestrol are some of the prevalent risk factors associated with the onset of the disease.

Some researchers also suggested women who have several sexual partners or often change of sexual partners are at increased risk of infected by the Human papillomavirus (HPV), one of the major cause of cervical cancer.

Dr. Diane Cooper, the lead scientist in the cancer researcher in the examine the sexual activity in the risk of cervical cancer of among South African women wrote, "cervical cancer risk is associated with increased sexual activity. Initiatives to encourage later commencement of sex, and limiting the number of sexual partners would have a favorable impact on the risk of cancer of the cervix and other sexually transmitted infections".

These results clearly suggested that women who are sexually active and have a number of sexual partners should take extreme precautions to protect themselves against HPV infection.

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

On finding natural chemoprevention which holds great potential for cancer management as lower, clinically tolerable doses of individual agents for the treatment of cervical cancer, the cancer team at the Manipal University examined the effect of combination treatment of sulforaphane (SFN) and eugenol on HeLa cells.

Injection with variable dose combinations of SFN and eugenol showed a significant effect in inducing cell cytotoxicity and apoptosis at the lower and synergistic effect at higher sub-lethal doses to the cancer cells.

Futhermore, application of chemo drugs gemcitabine combined with the low- and high-dose of SFN combinations showed no significant cell death at lower doses compared to that of cell cytotoxicity in gemcitabine alone.

These results clearly suggested that SFN can only elevate the efficiency and lower the dose of certain chemo drugs which act on certain pathways in inducing cytotoxicity and cell death with decreasing side effects.

Additional examination of the effect of SFN and eugenol combinations researchers found that SFN significantly inhibits the expression of the proteins associated with cell proliferation and production of inflammatory cytokines.

Dr. Hussain A, the lead scientists in the final report wrote, "2 (or more) chemopreventive agents can act antagonistically or synergistically necessitating elucidation of possible mechanistic interactions for favorable and reliable outcomes of dietary components in the field of cancer prevention".

Compared to chemo drugs, injection of sulforaphane alone exerted a strong effect in inducing dose-dependent selective cytotoxicity in HeLa cells without causing harm to the to normal cells.

The finding emphasized that the bioactive compound processes a safe cytotoxicity profile compared to conventional chemo medicine.

Also, sulforaphane alone was found to expresse its efficacy through analysis of genes similar to that of SFN and eugenol combination.

In human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells, SFN inhibited the viability of both HeLa and HepG2 cells by inducing apoptosis, observed by the formation of apoptotic bodies and the accumulation of the sub-G1 phase.

In-depth differentiation of SFN activity, researchers discovered that SFN not only induces cell death through the cancer cells cycle arrest but also activates the genes associated with the programming cell death and cell apoptosis by blocking the expression of cell proliferative proteins.

Taken altogether, sulforaphane SFN may be considered a chemo and natural medicine for the prevention and combined with certain primary medicine for the treatment of cervical cancer with a reduced side effect through lowering the dose of the applied chemo drug.

References
(1) Concurrent sulforaphane and eugenol induces differential effects on human cervical cancer cells by Hussain A1, Priyani A, Sadrieh L, Brahmbhatt K, Ahmed M, Sharma C.(PubMed)
(2) Anti-carcinogenic effects of sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cells by Sharma C1, Sadrieh L, Priyani A, Ahmed M, Hassan AH, Hussain A.(PubNed)
(3) Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3 by Park SY1, Kim GY, Bae SJ, Yoo YH, Choi YH.(PubMed)
(4) Determinants of sexual activity and its relation to cervical cancer risk among South African Women by Diane Cooper,

1 Margaret Hoffman,1 Henri Carrara,1 Lynn Rosenberg,2 Judy Kelly,2Ilse Stander,3 Lynnette Denny,4 Anna-Lise Williamson,5,6 and Samuel Shapiro. (PMC)

Wednesday, 30 January 2019

Honey, The Potential Food for Obesity Control

By Kyle J. Norton

On seeking natural therapy with no side effects, scientists may have found a bee based product for the treatment of obesity, according to studies.

Compared to an ideal weight, that reduces the risk of cardiovascular disease, body weight greater than 20 percent is considered obese.

Obesity is a medical condition caused by excess body fat has accumulated over time, while overweight is a condition of excess body weight relative to the height.

According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity.

Epidemiological studies in the investigation of the complication of obesity found that cardiovascular problems such as high blood pressure, heart disease, accelerated atherosclerosis, and stroke... and chronic lower back pain are most common disease complications associated with obesity.

According to data from the National Health and Nutrition Examination Survey (NHANES), 2013–2014, more than 1 in 3 and 13 adults in the US were considered to have obesity and extreme obesity, respectively.

Although there are many risk factors involved the onset of the disease, some researchers suggested an unhealthy lifestyle is one of the major causes of obesity in the Western world.

Dr. Robert F. Kushner, in the examination of the unhealthy lifestyle risk of obesity of the 53‐item lifestyle pattern questionnaire posted on a commercial weight loss program Web site collected from 2004 through 2008, wrote, "unhealthy lifestyle patterns in diet, exercise, and coping were highly prevalent among this population".

The results findings clearly suggested a strong correlation between diet, exercise, and obesity.

Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.

The liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

In the urgency to find a natural remedy for the treatment of widespread obesity in the Western world, researchers evaluated the potential of honey consumption in controlling obesity.

The study compared the two local Malaysian honey types: Gelam and Acacia honey activities in reducing excess weight gain and other parameters related to obesity.

Male Sprague-Dawley rats selected to the study were induced obese by a high-fat diet (HFD) prior to introduction with/without honey or orlistat for four weeks.

Rats fed with Gelam honey showed significant reductions in excess weight gain and adiposity index compared to HFD rats.

Furthermore, parameters related to obesity such as levels of plasma glucose, triglycerides, and cholesterol, plasma leptin and resistin, liver enzymes, renal function, and relative organ weight in Gelam and Acacia honey treated groups were reduced significantly, compared to obese rats.

Compared to the treatment of orlistat, Gelam and Acacia honey showed similar results without inducing hepatotoxicity effects.

Hepatotoxicity is a known side effect of orlistat.

Where Orlistat is a drug used for the treatment of obesity, sold over-the-counter as Alli by GlaxoSmithKline in the United Kingdom and the United States.

Dr. Samat S, the lead scientists wrote in the final report, "consumption of honey can be used to control obesity by regulating lipid metabolism and appears to be more effective than orlistat".

Taken altogether, hiney, particularly Gelam and Acacia honey may be considered anti-obesity functional remedies with no side effects, pending to the confirmation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Four-Week Consumption of Malaysian Honey Reduces Excess Weight Gain and Improves Obesity-Related Parameters in High Fat Diet Induced Obese Rats by Samat S1, Kanyan Enchang F1, Nor Hussein F2, Wan Ismail WI. (PubMed)

Artichoke, the Potential Anti Type 2 Diabetes Herbal Remedy with No Side Effects, According to Studies

By Kyle J. Norton

Artichoke may be used as a functional remedy for the treatment of type 2 diabetes with no side effects, according to studies.

Type 2 diabetes is a medical disease characterized by not enough insulin in the bloodstream due to dismissed pancreas function or in properly use the insulin of the body.

In other words, type 2 diabetes is caused by the beta cell which is responsible for the production of insulin died off or the clogged up of the insulin receptor sites, which allow the cell to bind with insulin in the blood to transform glucose to energy.

The hallmark of type 2 diabetes is insulin resistance.

Types 2 diabetes is a common disease of adults in the Western world. According to the statistics provided by the by the Centers for Disease Control and Prevention (CDC), over 100 million U.S. adults are now living with diabetes or prediabetes.

And, in 2015, 30.3 million Americans or 9.4 percent of the U.S. population have diabetes.

The disease has caused a significant economic burden in the world. In the US, the annual economic cost for each individual with type 2 diabetes is $11,917.

In fact, the direct diabetes costs in a country’s gross domestic product (GDP) per capita, the USA stood out as having particularly high costs, compared to other countries.

Some researchers suggested that the widespread type 2 diabetes in the overweight population in the US may be correlated to the promotion of the Western diet over the past few decades.

Dr. Lu Qi, and colleagues in the examination of the Western diet in types 2 diabetics wrote, "The Western dietary pattern was not associated with diabetes risk among those with a lower GRS."

And, "In addition, we found that intakes of processed meat, red meat, and heme iron, which characterized the Western dietary pattern, showed significant interactions with GRS in relation to diabetes risk (P for interaction = 0.029, 0.02, and 0.0004, respectively). The diet-diabetes associations were more evident among men with a high GRS (≥12) than in those with a low GRS".

The results indirectly suggested that people who follow the Western diet with a genetic risk score (GRS) are at an increased risk of type 2 diabetes.

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Scientists on finding a natural ingredient for the treatment of diabetes examined the artichoke (JA) potential in attenuating lipid disturbances and insulin resistance (IR) in an animal model.

Wistar rats selected to the study were fed a control diet, a 60 % fructose-enriched diet (FRU), or an FRU with 10 % JA (n 6-7) for 4 weeks. An oral glucose tolerance test was carried out on day 21.

Injection of JA showed a significant effect in improving the expression of the genes associated with fibrosis and inflammation and insulin resistance according to the global gene expression analyses and oral glucose tolerance test, respectively.

Dr. Chang WC, the lead scientist after taking into account co and confounder suggested that 10 % JA supplementation may be beneficial for the prevention of the onset of diabetes.

Furthermore, in order to reveal more information about artichoke anti-diabetes effect, researchers conducted a randomized, double-blinded, placebo-controlled study on 60 subjects with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or newly diagnosed type 2 diabetes.

The selected subjects were randomly assigned to either a group that ingested 40 g of a Jerusalem artichoke and fermented soybean powder mixture (19.45 g each) daily or a group that received a placebo for 12 weeks.

Group treated with supplementation with the Jerusalem artichoke and fermented soybean powder mixture reduced the levels of fasting glucose (p < 0.001) and FFAs (p = 0.034), glucose at 60 min.

According to the homeostasis model assessment, the supplement also inhibits the insulin resistance (p = 0.018), and the urinary 8-epi-prostaglandin F2α (8-epi-PGF2α) level, a marker of free radical-catalyzed lipid peroxidation.

Moreover, the change of glucose at 120 min (r = 0.472, p = 0.027) and the glucose under the curve (AUC) were positively correlated with the reduction of plasma malondialdehyde, an indication of oxidative stress.

The finding clearly suggested the efficacy of the consumption of a Jerusalem artichoke and fermented soybean powder mixture against the overexpression of glucose for 12 weeks, particularly, in the newly diagnosed type 2 diabetes.

Taken altogether, artichoke used alone or combined with other herbal products may be considered functional remedies for the prevention and treatment of type 2 diabetes, pending to the confirmation of larger sample size and multicenter human study.

References
(1) Beneficial effects of soluble dietary Jerusalem artichoke (Helianthus tuberosus) in the prevention of the onset of type 2 diabetes and non-alcoholic fatty liver disease in high-fructose diet-fed rats by Chang WC1, Jia H2, Aw W2, Saito K2, Hasegawa S3, Kato H1. (PubMed)
(2)The effects of Jerusalem artichoke and fermented soybean powder mixture supplementation on blood glucose and oxidative stress in subjects with prediabetes or newly diagnosed type 2 diabetes.
Ahn HY1, Kim M1, Seo CR2, Yoo HJ3, Lee SH4, Lee JH. (PubMed)
(3) Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men by Lu Qi, Marilyn C Cornelis, Cuilin Zhang, Rob M van Dam, and Frank B Hu. (PMC)

Ginger, The Natural Anti Oral Cancer Herbal Remedy with No Side Effects

By Kyle J. Norton

Scientists may have found a natural remedy for the prevention and treatment of oral cancer with no side effects, according to studies.

Oral cancer also known as mouth cancer is a medical condition characterized by irregular cell growth in the tissue of the oral cavity, due to the alternation of cell DNA.

Most cases of oral cancer begin in the cells on the surface of the inner lining of oral tissue.

However, at the advanced stage, oral cancer cells can travel a distance away to infect other healthy tissue and organs, leading to the secondary metastasis.

According to the statistic provided by the American Cancer Society, in 2018, approximately 51,540 people were diagnosed with oral cavity or oropharyngeal cancer. The disease causes the death of an estimated 10,030 people.

The 5-year survival rate of oral cancer is 66%, including all stages.

Family history, smoking, alcohol drinking, infected by HPV virus, poor hygiene and genetic preposition are some of the risk factors associated with the disease.

Some researchers suggested that oral sex may be one of the major prevalent risk factor involved the development of oral cancer. Dr. Rajiv Saini in the examination of the connection of oral sex and oral cancer, wrote, "The diverse conduit in the oral cavity that provides as a gateway of exposure of infection from the oral cavity to bloodstream include any open sores, cuts, abrasions, or bleeding gum disease such as gingivitis and periodontitis".

"Accumulating molecular and pathologic evidence has strengthened the hypothesis that HPV infection could play a role in the etiology of some oral squamous cell carcinomas.

And, "To reduce the risk of infection during unprotected oral sex, limit exposure to sexual fluids and ensure that no cuts or lesions are present in the mouth or on the genitals. Good oral health, free from bleeding gums, lip sores, cuts, broken skin, and oral epithelium, enormously reduces the chances of transmission of infection among the partners indulging in oral sex".

These results strongly suggested people who perform oral sex before, during and after sexual intercourse may be at risk of oral cancer due to infected by the HPV virus.

Researchers on finding a natural compound for the inhibition of oral cancer examined the [6]-Shogaol ([6]-SHO), a major constituent of ginger anti-tumor activity.

[6]-SHO showed a significant effect in preventing oral squamous cell carcinoma by activating proapoptotic factors in vitro and in vivo experimental model.

In the inflammation and cell proliferation assays, injection of [6]-SHO inhibited the oral cancer cell line through cytotoxicity induced by the expression of proinflammatory cytokines, proteins associated with cell apoptosis and anti-cell survival mechanisms.

Furthermore, in the oral cancer cells, oral administration of [6]-SHO strongly inhibited phosphorylation in stimulating the enzymes which carry energy the cancer cells and enzymes in the degradation of cellular response to inflammation.

Dr. Annamalai G, the lead scientist said, " [6]-SHO is a novel functional agent capable of preventing DMBA induced inflammation and cell proliferation associated tumorigenesis by modulating multiple signaling molecules".

Additionally, in order to reveal more information about 6-Gingerol anti-oral cancer properties, researchers investigated the compound in human oral (SCC4, KB) with or without wortmannin, rapamycin, and cisplatin.

6-Gingerol showed dose-dependent cytotoxicity in the oral cell line.

Combinations of 6-gingerol with wortmannin and cisplatin showed additive effects, while with rapamycin, it showed 50% cytotoxicity equivalent to that of IC50 of 6-gingerol alone.

Treatment with 6-gingerol exhibited S-phase arrest in SCC4 cells. But 6-Gingerol, wortmannin, and rapamycin treatment showed almost two-fold higher expression of proteins associated with cancer cells apoptosis.

Dr. in the final report wrote," 6-gingerol appears to be a safe and potent chemotherapeutic/chemopreventive compound acting through cell cycle arrest and induction of apoptosis in human oral....cells".

Taken altogether, ginger processed bioactive ingredient 6-gingerol and [6]-Shogaol may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of oral cancer, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) [6]-Shogaol attenuates inflammation, cell proliferation via modulate NF-κB and AP-1 oncogenic signaling in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis by Annamalai G1, Suresh K. (PubMed)
(2) 6-Gingerol Mediates its Anti Tumor Activities in Human Oral and Cervical Cancer Cell Lines through Apoptosis and Cell Cycle Arrest by Kapoor V1, Aggarwal S1, Das SN. (PubMed)
(3) Oral sex and oral cancer: A virus link by Rajiv Saini. (PMC)

Tuesday, 29 January 2019

Herbal cayenne Normalizes the Levels of High Blood Cholesterol with No Side Effects, According to Studies

By Kyle J. Norton

Herbal Cayenne processed a high amount of bioactive compound capsaicinoids may have a strong and potential effect in reducing levels of high blood cholesterol, according to studies.

Hyperlipidemia is a condition of abnormally high levels of cholesterol in the bloodstream.

Cholesterol is a waxy substance which is produced either by the liver or injected from animal food sources.

Cholesterol found in our body is needed for our body to build cell walls, hormones, and vitamin D, and create bile salts that aid digestion. However, too much of them, in most cases due to the intake of animal protein can cause plaques built up on the arterial wall, the major cause of heart disease and stroke.

More precisely, if levels of low-density lipoprotein are high compared to high-density lipoprotein which returns the accessed cholesterol back to the liver, you have high blood cholesterol.

In other words, healthy blood cholesterol is any levels with either less than or equal to 4 (low-density lipoprotein/ 1 (high-density lipoprotein).

According to the statistics, in 2015-2016, by age and gender, a total of 12.4 percent of adults aged 20 years and over had high cholesterol in the United States.

Although there are many risk factors such as obesity, large waist circumference, physically inactive, smoking and diabetes associated with the onset of high blood cholesterol, researchers suggested that a poor diet with rich in saturated and trans fat, processed foods is the major cause of high blood cholesterol in the Western world.

Dr. Joan Carles Escolà-Gil and colleagues in the concern about the Western diet pattern in risk of high blood cholesterol wrote, "The HFHC diet caused a significant increase in plasma cholesterol, HDL cholesterol, and liver cholesterol and enhanced macrophage-derived [3H]cholesterol flux to feces by 3- to 4-fold, (in tested mice)".

And, " The HFHC diet caused 1.4- and 3-fold increases in [3H]cholesterol efflux to plasma and HDL-derived [3H]tracer fecal excretion".

The results strongly indicated there is a clinical significance of high-fat diet in the increased substantially risk of high blood cholesterol.

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.

The herbal medicine has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.

The chemical constituents of Cayenne include capsaicin, capsacutin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.

Researchers on finding a herbal medicine for the treatment of high blood cholesterol examined the antihyperlipidemic effects of capsaicinoids, the active compounds in chili pepper.

Hamsters selected to the study were divided into five groups and fed a high-cholesterol diet containing 0 % (CON), 0.010 % (LD), 0.015 % (MD), 0.020 % (HD), and 0.030 % (VD) capsaicinoids, respectively, for 6 weeks.

Capsaicinoids reduced plasma total cholesterol, non-high-density lipoprotein, and triacylglycerols without affecting the levels of high-density lipoprotein.

Dietary capsaicinoids increased the fecal excretion of total acidic sterols possibly associated with an enzyme which oxidizes cholesterol and inhibited the liver X receptor alpha which was found to raised HDL-cholesterol and increased liver triglycerides in a wild-type mice study.

Furthermore, capsaicinoids not only decreased cholesterol absorption but also improved the levels of expression of COX-2 associated with the accumulation of lipids in circulation and liver, and lipid peroxidation in case of deficiency.

Dr. Liang YT, the lead scientist, after taking into account co and confounders wrote, "Capsaicinoids were beneficial in improving lipoprotein profile and aortic function in hamsters fed a high-cholesterol diet".

Moreover, in female ovariectomized Sprague-Dawley rats, the sham group and OVX control group were fed with high-cholesterol diets, whereas the treatment group (control diet containing 0.01% capsaicinoids) was fed with high-cholesterol plus 0.01% capsaicinoids diet for 21 days.

Injection of capsaicinoids significantly decreased the body weight gain, plasma total cholesterol, LDL cholesterol, and triacylglycerol without affecting the high-density lipoprotein cholesterol in the OVX rats.

These changes in plasma lipoprotein profile were accompanied by a greater excretion of total bile acid in feces and small intestinal contents.

The efficacy of the compound in the inhibition of high blood cholesterol was attributed to the significantly enhanced the expressions of hepatic cholesterol 7α-hydroxylase, an enzyme and receptor potential vanilloid type-1 associated with cholesterol oxidation.

Dr. Zhang L, the lead researchers wrote in the final report, "The hypocholesterolemic activity of capsaicinoids is caused by the stimulating conversion of cholesterol to bile acids by upregulation of cholesterol 7α-hydroxylase expression and the increase in fecal total bile acid excretion".

Taken altogether, herbal cayenne processed major bioactive ingredient capsaicinoids may be considered a function fruit for the prevention and treatment of high blood cholesterol, pending to the

larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Capsaicinoids lower plasma cholesterol and improve endothelial function in hamsters by Liang YT1, Tian XY, Chen JN, Peng C, Ma KY, Zuo Y, Jiao R, Lu Y, Huang Y, Chen ZY.(PubMed)
(2) The hypocholesterolemic effect of capsaicinoids in ovariectomized rats fed with a cholesterol-free diet was mediated by inhibition of hepatic cholesterol synthesis by Zhang L1, Fang G, Zheng L, Chen Z, Liu X.(PubMed)
(3) Hypocholesterolemic effect of capsaicinoids by increased bile acids excretion in ovariectomized rats by Zhang L1, Zhou M, Fang G, Tang Y, Chen Z, Liu X.(PubMed)

Tualang Honey, The Potential Anti Cervical Cancer Functional Food

By Kyle J. Norton

Scientists may have located a natural whole food for the prevention and treatment of cervical cancer with no side effects, some studies found.

Cervical cancer is the chronic condition caused cell growth disorderly in the tissue of the cervix.

Most cases of cervical cancer start on the cells in the surface of the inner lining tissue of the cervix.

Most patients at this stage of cervical cancer do not experience any symptoms.

As cancer progresses, most patients may experience the symptoms of blood spots or light bleeding between or following periods, longer than usual and heavy menstrual bleeding, increased vaginal discharge, particularly, bleeding after intercourse, douching.

At this stage, cervical cancer can travel a distance away to cause metastasis to other healthy tissue and organs through fluids and blood circulation.

If you have experienced some of the above symptoms, please check with your doctor to rule out the cervical cancer possibility.

Although certain risk factors such as having many sexual partners, long-term use of birth control pills (oral contraceptives), early engaging in sexual contact are associated with the onset of the disease, Human papillomavirus (HPV) infection is one of major cause that has been under intensive investigation.

Belief or not, there are over 100 different HPV types have been identified and classified as high risk in almost all cervical cancers (>99.7%).

Out of this 100 different HPV, HPV16 is the most prevalent type in both low-grade disease and cervical neoplasia.

Dr. Doorbar J at the National Institute for Medical Research, said, "Most cervical cancers arise within the cervical transformation zone at the squamous/columnar junction, and it has been suggested that this is a site where productive infection may be inefficiently supported"

"Cancers usually arise in individuals who fail to resolve their infection and who retain oncogene expression for years or decades. In most individuals, immune regression eventually leads to clearance of the virus, or to its maintenance in a latent or asymptomatic state in the basal cells".

These results clearly stage, most of the initiation of HPV infection is stopped by the immune system first line of defense before the virus penetrates through the cervical cell membrane on the surface of the inner lining.

In other words, women who have a weakened immune system are at substantial risk to the disease.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient or whole food for the prevention and treatment of cervical cancer, researchers examined the Tualang honey (Agromas) anti-cancer effect.

Tualang honey (Agromas) (TH) were applied with increasing doses of TH (1-10%) for up to 72 h to the human breast (MCF-7 and MDA-MB-231) and cervical (HeLa) cancer cell lines; as well as in the normal breast epithelial cell line, MCF-10A.

At concentrations (EC(50)) of 2.4-2.8%., Tualang honey increased in lactate dehydrogenase (LDH) leakage from the cancer cell membranes, an indication of cytotoxicity to all three cancer cells.

Furthermore, application of TH also reduced the mitochondrial membrane potential (Δψ(m)) in response to energy storage in the cancer cell lines after 24h of treatment.

TH also stimulated the proteins associated with cancer cells apoptosis.

The evidence suggested that TH has significant anticancer activity against human cervical cancer cell lines.

Additionally, in the evaluation of bee bread (BB), a fermented mixture of plant pollen, honey, and bee saliva against HeLa (cervical carcinoma) cancer cells line, researchers found that application of BB displays a moderate activity in the inhibition of the cancer cell line through cytotoxicity with doses ranging from >400 to 68 µg/mL).

The inhibition of the human cervical cancer cell line was attributed to the main phenolic compounds also found abundantly in the Tualang honey.

The in-depth analysis suggested that BB induces HeLa cell death through stimulating the function of free radicals in the induction of oxidative stress to cause cytotoxicity.

Taken altogether, honey or Tualang honey may be considered a functional food for the prevention and combined with the primary therapy for the treatment of cervical cancer.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines by Fauzi AN1, Norazmi MN, Yaacob NS. (PubMed)
(2) Flavonoid Composition and Antitumor Activity of Bee Bread Collected in Northeast Portugal by Sobral F1, Calhelha RC2, Barros L3,4, Dueñas M5, Tomás A6, Santos-Buelga C7, Vilas-Boas M8, Ferreira IC9. (PubMed)
(3) Molecular biology of human papillomavirus infection and cervical cancer by Doorbar J. (PubMed)

Ginger, The Potent Anti Alzheimer's disease Inhibitor, Scientists Say

By Kyle J. Norton

Ginger may be the next pharmaceutical target to extract a single ingredient medicine for the treatment of Alzheimer's disease, some scientists found.

Alzheimer's disease is a common neurodegenerative disease in the elderly characterized by slowly destroys memory and thinking skills and, eventually, the ability to carry out the daily tasks.

According to the to the Centers for Disease Control and Prevention (CDC), Alzheimer’s disease falls sixth on the list of leading causes of death in the United States.

The average time from diagnosis to death was about four years.

Alzheimer's disease is also increased with the increase in age. In the total of 2,566 people, ages 65 and older under the test of dementia, 559 participants without dementia at the start of the study developed Alzheimer’s disease.

Most common causes of Alzheimer's disease are the combination of genetic, lifestyle, and environmental factors.

However, aging is one most risk factors associated with the onset of the disease in the elderly. Statistics show, the number of people with the disease doubles every 5 years beyond age 65. About one-third of all people age 85 and older may have Alzheimer's disease.

Some researchers suggested that the increase in age and risk of Alzheimer's disease can be attributed to the shrinking of certain parts of the brain, and long-term low-grade inflammation, neuron damage induced by oxidative stress due to overexpression of free radicals.

Dr. Tuppo EE, the lead author of the neuro team at the Western University of Health Sciences said, "There is increasing evidence that free radical-induced oxidative damage may play a role in the pathogenesis of Alzheimer's disease. Free radicals are reactive oxygen compounds that may attack and damage lipids, proteins, and DNA".

And, "The brain is especially sensitive to oxidative damage because of its high content of readily oxidized fatty acids, high use of oxygen, and low levels of antioxidants".

These results clearly suggested that people who follow a healthy diet with high antioxidants such as fruits and vegetables, whole grain and fewer in red meat and processed foods may have a substantially lower risk of Alzheimer's diseases.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

On finding the natural ingredient and whole food with a potential effect on patients with Alzheimer's disease, researchers looked into Ginger (Zingiber officinale), a common dietary adjunct that not contributes to the taste and flavor of foods, but also contain a number of potentially bioactive phytochemicals having valuable medicinal properties.

The differentiation of the binding interactions between active ginger components and various anti-Alzheimer drug targets, researchers suggested the approach could be a promising computational tool to aid optimization of lead compounds obtained from the ginger.

The hydrophobic/hydrophilic interactions of ligands isolated from ginger showed to target acetylcholinesterase, the functioning neurotransmitters, and receptors c-Jun N-terminal kinase which plays an important role in the onset of cognitive impairment.

Additionally, researchers found that all isolated compound is satisfied the Lipinski's rule of five, making them potentially promising drug candidates for the treatment of Alzheimer's disease.

Where Lipinski's rule of five is simply the rule of five (RO5) is a rule to determine if a chemical compound with a certain pharmacological or biological activity has chemical properties.

Moreover, the in-depth investigation of the possible mechanisms of action of these compounds against the AD, scientists compared 4 bioactive compounds isolated from ginger to inhibitors of human acetylcholinesterase (HssAChE), the HssAChE inhibitor and commercial drug in use against the AD, donepezil (DNP).

Unsurprisingly, two among the compounds studied: (E)-1,7-bis(4-hydroxy-3-methoxyphenyl) hept-4-en-3-on and 1-(3,4-dihydroxy-5-methoxyphenyl)-7-(4-hydroxy-3- ethoxyphenyl) heptane-3,5-diycl diacetate, are considered promising new HssAChE inhibitors that could be as effective as DNP.

Based on these results, researchers said, "the binding of the studied compounds in the different binding pockets inside HssAChE and established the preferred interactions to be favored in the design of new and more efficient inhibitors".

Taken altogether, ginger processed abundant bioactive compounds that act as acetylcholinesterase (HssAChE) inhibitor may be used as a functional food for the prevention and treatment of Alzheimer's disease without inducing any side effects.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Ginger components as new leads for the design and development of novel multi-targeted anti-Alzheimer's drugs: a computational investigation by Azam F1, Amer AM2, Abulifa AR2, Elzwawi MM2. (PubMed)
(2) A molecular dynamics study of components of the ginger (Zingiber officinale) extract inside human acetylcholinesterase: implications for Alzheimer disease by Cuya T1, Baptista L2, Celmar Costa França T. (PubMed)
(3) Ginger fermented with Schizosaccharomyces pombe alleviates memory impairment via protecting hippocampal neuronal cells in amyloid beta1-42 plaque injected mice by Huh E 1, Lim S , Kim HG , Ha SK , Park HY , Huh Y , Oh MS. (PubMed)

Monday, 28 January 2019

Phytochemical Triterpenoid Which Inhibits Nonalcoholic Fatty Liver Disease

By Kyle J. Norton

Scientists may have found a bioactive ingredient for the prevention and treatment of nonalcoholic fatty liver disease with no side effects, according to studies.

Nonalcoholic Fatty liver disease (NAFLD) is a condition of the fatty liver diseases as a result of accumulated of fat in the liver over time, not caused by abusive alcohol consumption.

Most patients in the early stage of nonalcoholic fatty liver disease do not experience any symptoms until the disease has advanced to the critical stage.

According to the statistic, NAFLD is the most common cause of liver disease in the Western world.

Most diseases associated with NAFLD are obesity, high blood pressure, diabetes, and high cholesterol.

People with insulin resistant, diabetes, high blood pressure, high blood fat levels and/or the metabolic syndrome, are associated with an increased risk of NAFLD.

Other risk factors on the incidence of NAFLD are the increase in age, ethnicity and family history.

Believe or not, people who carry certain mutated gene also at a higher risk of the disease. Dr. Silvia Sookoian in the concern of the global epidemic risk of Nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease wrote, "Although the disease is relatively benign in the early stages, when severe clinical forms, including nonalcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma, occur, they result in worsening the long-term prognosis.".

And, " A growing body of evidence indicates that NAFLD develops from a complex process in which many factors, including genetic susceptibility and environmental insults, are involved".

Triterpenoid is various unsaturated hydrocarbons, found in essential oils and oleoresins of plants, including Ilex hainanensis Merr.

On finding a natural ingredient or whole food for the prevention and treatment of non-alcoholic fatty liver disease with no side effects, researchers at the China Pharmaceutical University evaluated the effect of the triterpenoid-rich fraction (TF) from Ilex hainanensis Merr. on NAFLD in an animal model.

The study included Male Sprague-Dawley (SD) rats fed a normal diet (control) or high-fat diet (NAFLD model) 4 four weeks, following by the orally administrated TF (250 mg/kg) for another two weeks.

Before application of TF compound, rats fed a high-fat diet displayed an abnormally high blood cholesterol levels and a decline in liver function compared to control.

Application of TF on these rats not only restores the health issues caused by high-fat diet but also decreased the expression of plasma levels of triglyceride, total cholesterol, low-density lipoprotein cholesterol, and the high-density lipoprotein cholesterol.

Levels of alanine transaminase (p < 0.05), aspartate aminotransferase (p < 0.01), liver index (p < 0.05), the indication of liver oxidative stress and insulin resistance index (p < 0.05) were also decreased by TF adminsitration.

Futhermore, TF improved the liver lesions induced by the high-fat diet.

Moreover, TF injection also alleviated oxidative stress and inflammation status indicated by the decline levels of oxidative markers, free radicals, and pro-inflammatory cytokines.

Dr. Cui WX, the lead scientist, after taking into account co and confounders said, "TF has the potential ability to protect the liver against NAFLD by regulating lipids metabolism and alleviating insulin resistance, inflammation and oxidative stress".

Additionally, the study to reconfirm the traditional use of herbal Ilex hainanensis Merr. for the treatment of non-alcoholic fatty liver disease, researchers examine the compound Chlorogenic acid, kaempferol-7-O-β-d-glucoside, and ilexgenin, a novel triterpenoid, the three major bioactive components in I. hainanensis extract.

Compared to normal rats, application of I. hainanensis extract exerted a significant change in NAFLD rats.

The efficacy of the herbal extract was attributed to the anti-NAFLD activity of chlorogenic acid, kaempferol-7-O-β-d-glucoside, and ilexgenin A.

Taken altogether, phytochemical Triterpenoid may be considered a supplement for the prevention and treatment of non-alcoholic fatty disease pending to the large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Reference
(1) Pharmacokinetic study of major bioactive components in rats after oral administration of extract of Ilex hainanensis by high-performance liquid chromatography/electrospray ionization mass spectrometry by Jie Yanga,1, Fang Lva, 1, Xiao-qing Chenb, Wei-xi Cuia, Li-hong Chenc, Xiao-dong Wena, Qiang Wanga(Science direct)
(2) Triterpenoid-rich fraction from Ilex hainanensis Merr. attenuates non-alcoholic fatty liver disease induced by high fat diet in rats by Cui WX, Yang J, Chen XQ, Mao Q, Wei XL, Wen XD, Wang Q.(PubMed)
(3) Genetic predisposition in nonalcoholic fatty liver disease by bSilvia Sookoian1 and Carlos J. Pirola2(PMC)

Anacardic Acid, A Bioactive Ingredient Which Processes Anti Lung Cancer Potential

By Kyle J. Norton

Anacardic acids may be considered a bioactive ingredient for the prevention and treatment of lung cancer, some scientists found.

Lung cancer is a condition of the abnormal growth of the cells in the lung's tissue. Most cases of primary lung cancer start in the cells on the surface of the inner lining of lung tissue.

At the early stage, most patients do not experience any symptoms. However, as cancer continues to advance, it can put pressure on the nearby healthy tissue such as blood vessel and nerve cell, leading to localized symptoms and severe pain.

At the later stage, lung cancells can also travel through blood and fluids circulation to infect other healthy tissue and organ, leading to secondary metastasis.

According to the 2007 statistic, the most common form of primary lung cancers is derived from epithelial cells. In the US, lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women.

The most common form of lung cancer metastasis is brain cancer, according to the statistic, approximately, 40 percent of people with advanced lung cancer will develop brain cancer sometimes during the disease.

The causes of lung cancer are unknown. However, epidemiologically suggested that although there are many risk factors associated with the onset of lung cancers, smoking tobacco, and second-hand smoke are considered the most risk of the diseases.

Other risk factors include radon asbestos, occupational exposure to certain chemicals, outdoor air pollution, personal or family history of lung cancer, personal history of lung disease and long-term exposure to radiation.

Dr. Muhammad Furrukh, in the concern of tobacco smoking in the risk of lung cancer, said, "Tobacco smoking remains the most established cause of lung carcinogenesis and other disease processes" and "Over the last 50 years, tobacco refinement and the introduction of filters have brought a change in histology, and now adenocarcinoma has become the most prevalent subtype"

"Over the last decade, smoking also has emerged as a strong prognostic and predictive patient characteristic along with other variables".

Anacardic acids are phenolic lipids, phytochemicals of the organic acid found abundantly in cashews, mangoes, etc.

On finding a natural ingredient for the prevention and treatment of lung cancer, researchers looked into the anti-lung cancer effect of anacardic acid (AA), a constituent of the cashew nutshell.

Application of the chemical compound exerted a strong cytotoxic activity against A549 lung adenocarcinoma cells, through the expression of reactive oxidative spices.

AA also activated the proteins associated with cells apoptosis in A549 cells.

Furthermore, in the study of the efficacy of AA against cancer cells, researchers looked into the role of the expression of nuclear factor-kappaB (NF-kappaB) during the cancer inhibition.

Application of AA exerted a strong anti-cancer effect through a series of mechanisms, including induced cancer cells apoptosis by overexpression of proinflammatory cytokines correlated with the inhibition of various gene products associated with cancer cell proliferation and survival.

Moreover, the application of AA also blocked the formation of the formation of new blood vessels induced by the tumor.

The finding suggested that AA inhibits the function of NF-κB, a protein complex in controlling the transcription of DNA, cytokine production and cell survival.

Dr. Sung B, after taking into account co and confounders said, " (There is) a novel role for anacardic acid in potentially preventing or treating cancer through modulation of the NF-kappaB signaling pathway".

Taken altogether, Anacardic acid (AA) may be used for the prevention and treatment of lung cancer, pending to the confirmation of a larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca

Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Anacardic acid induces mitochondrial-mediated apoptosis in the A549 human lung adenocarcinoma cells by Seong YA, Shin PG, Kim GD. (PubMed)
(2) Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis by Sung B, Pandey MK, Ahn KS, Yi T, Chaturvedi MM, Liu M, Aggarwal BB. (PubMed)
(3) Tobacco Smoking and Lung Cancer. Perception-changing facts by Muhammad Furrukh. (PMC)

The Secondary Metabolites Berberine Reverses Polycystic Ovarian Syndrome (PCOs), Human Studies Show

By Kyle J. Norton

Scientists may have discovered a bioactive and plan base ingredient for the prevention and treatment of polycystic ovarian syndrome (PCOs) with no side effects, according to studies.

The polycystic ovarian syndrome is an endocrinologic disease caused by undeveloped follicles clumping on the ovaries that interfere with the function of the normal ovaries as resulting of enlarged ovaries.

Women with PCOs are found to produce an excessive amount of androgen, leading to a male pattern hair development, acne, irregular period or absence of period, weight gain and infertility.

The condition affects over 5% of women population or 1 in 20 women. However, the actual numbers may be substantial high because a large percentage of women in the early stage of PCOs are undiagnosed.

Some researchers suggested that women with PCOs are at a higher risk of the onset of diabetes and heart disease.

What cause PCOs? Why some women are more susceptible to the incidence and others do not even they have the same health condition and family history? No researchers can answer this question.

However, they do know according to the epidemiological studies that people who carry mutated gene inherited from the parent, with chronic inflammatory disease and having insulin resistance are at the increased risk of PCOs.

Treatment of PCOs can vary and totally depend on the range of symptoms, or just one.

Some researchers suggested that lifestyle change may be the best for reducing the symptoms in women with PCOs. Weight loss of just 5% can lead to a significant improvement in PCOS symptoms.

Dr. Sedigheh Sedigh in the study to compare the lifestyle in women With polycystic ovary syndrome and healthy women said, "there was a significant relationship between PCOS and inappropriate diet (p=0.009), low physical activity (p=0.009), but no relationship was observed between PCOS and unhealthy behaviors".

These results clearly suggested that women who follow the Western diet with lack of exercise are associated with a substantial risk of PCOs. In other words, a change to a healthy lifestyle has a strong impact in reducing the incidence onset for women without PCOs and symptoms for women with PCOs.

Berberine is a phytochemical found in the group of protoberberine group of isoquinoline alkaloids, in many herbal plants including Oregon grape, barberry, turmeric, goldenseal, etc.

With an aim to find a natural ingredient for the treatment of the reproductive and metabolic disorder associated with insulin resistance (IR) in women with polycystic ovary syndrome (PCOS), researchers at the Harbin Medical University examine the potential therapeutic value of berberine (BBR)for PCOS.

The study included 49 wone with PCOS and IR randomized assigned into one of three treatment groups: BBR+compound cyproterone acetate (CPA; n=31), MET+CPA (n=30), and placebo+CPA (n=28) for 3 months.

After 3 months, BBR treatment group showed a decrease in waist circumference and waist-to-hip ratio (WHR; P<0.01), total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C; P<0.05) as well as increase in high-density lipoprotein cholesterol (HDLC) and sex hormone-binding globulin (SHBG) compared to MET group.

Compared to the placebo, the BBR group demonstrated a similar effect as in the comparison with the control group.

These results suggested that BBR Intake of BBR improved some of the metabolic and hormonal derangements in a group of treated Chinese women with PCOS.

Dr. Wei W, the lead author in the final report wrote, "Main effects (of BBR) could be related to the changes in body composition in obesity and dyslipidemia."

Furthermore, in order to reconfirm the effect of Berberine in PCOs subjects, researchers launched a review of the photochemical activity on polycystic ovary syndrome (PCOS) patients with insulin resistance (IR).

The search od the database of medical literature for the randomized controlled trials in human beings up to July 2018, found a total of 9 randomized controlled trials satisfied the guidelines and criteria.

Berberine not only showed an effect in lowering blood sugar levels in db/db mice and anti-dyslipidemia inhuman.

Berberine exerted the similar effects similar to those of metformin (MET) in alleviating insulin resistance, improving glycolipid metabolism, or reproductive endocrine condition.

MET combined with BBR was not superior to MET alone, but cyproterone acetate (CPA) combined with BBR was superior to CPA alone in improving some of the reproductive endocrine indices.

The combination of BBR and Chinese herbs also showed a positive effect on all the parameters mentioned above.

Dr. Meng-Fei Li, the lead scientist, at the final report, said, "BBR showed a promising prospect in treating PCOS-IR"

Although the results indicated that Berberine has a potential effect on the treatment of metabolic and hormonal derangements in women with PCOs, due to the limitation of the studies, further data collection large example size and multi-centers studies performed with human consumption of the bioactive compounds during the course of the disease will be necessary to complete the picture of Berberine anti PCOs possibilities.

References
(1) A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome by Wei W, Zhao H, Wang A by Sui M, Liang K, Deng H, Ma Y, Zhang Y, Zhang H, Guan Y. (PubMed)
(2) The Effect of Berberine on Polycystic Ovary Syndrome Patients with Insulin Resistance (PCOS-IR): A Meta-Analysis and Systematic Review (Research Gate)
(3) Comparison of Lifestyle in Women With Polycystic Ovary Syndrome and Healthy Women by Sedigheh Sedighi,1 Sedigheh Amir Ali Akbari,2 Maryam Afrakhteh,3 Taraneh Esteki,4Hamid Alavi Majd,5 and Zohreh Mahmoodi. (PMC)

Sunday, 27 January 2019

Avocado, the Next Prominent Anti Prostate Cancer Functional Fruit, Scientists Say

By Kyle J. Norton

Avocado may be the generation whole fruit medicine for the prevention and treatment of prostate cancer with no side effects, some scientists found

Prostate cancer is a medical condition in which the cells of the prostate has become cancerous, causing abnormal cells growth.

Most prostate cancers are slow growing and can be detected during the physical (rectum) exams.

Most cases of prostate cancer start in the cell on the surface of the inner lining of the prostate tissues.
At the advanced stage, as the tumor continues to grow, it may suppress the nearly healthy tissue and nerve cells leading to severe symptoms and pain.

According to the statistic provided by the American Cancer Society, 1 in 9 men will be diagnosed with prostate cancer during his lifetime. Approximately, 6 cases in 10 are diagnosed in men aged 65 or older.

Most common symptoms of prostate cancer include frequent urination, weak or interrupted urine flow or the need to strain to empty the bladder. and the urge to urine frequently at night due to the large size of the tumor that suppresses the bladder and the flow of urine.

Some patients may also experience symptoms blood in the urine, blood in the seminal fluid and pain or burning during urination caused by the tumor that breaks the nearby small veins and nerve cells.

At this stage, cancerous cells from the prostate gland can also travel a distance away to infect other healthy tissue and organ, leading to the secondary metastasis.

There are many risk factors associated with the onset of prostate cancer. However, the increase in age, location and behavioral correlates are some prevalent risk of the disease onset.

According to the University of Zurich, factors that may enhance prostate cancer risk include frequent consumption of dairy products and, possibly, meat and increased physical activity, intakes of tomatoes, cruciferous vegetables, and soy are possible preventative behavioral factors.

These results indicated that by following a healthy diet with moderate exercise, the risk of prostate cancer can be reduced substantially.

Avocado is commercially valuable fruit cultivated in tropical climates throughout the world. It is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.

With an aim to discover a natural ingredient or whole food for the prevention and treatment of prostate cancer with no side effects, researchers at the University of the West Indies investigate the intake of dietary MUFAs from whole fruit of avocado in the risk of prostate cancer (PCa).

The case study included 209 men 40-80 years old with newly diagnosed, histologically confirmed prostate cancer and 226 cancer-free men, attending the same urology clinics.

Higher intakes of dietary MUFA were inversely related to prostate cancer. The principal source of dietary MUFA of the participants was avocado intake. Dietary intakes of other fats were not associated with PCa.

Dr. Jackson MD, the lead author wrote in the report, "Whole-blood and dietary MUFA reduced the risk of prostate cancer. The association may be related to avocado intakes".

Researchers at the University of California agreed that the avocado is known as a rich source of monounsaturated fatty acids, for treatment of prostate cancer, but suggested that other bioactive substances including carotenoids, which might contribute to cancer preventive properties similar to those attributed to other fruits and vegetables.

In vitro, injection of acetone extract of avocado containing carotenoids and tocopherols inhibited the growth of both androgen-dependent (LNCaP) and androgen-independent (PC-3) prostate cancer cell lines.

Incubation of PC-3 cells with the avocado extract led to G(2)/M cell cycle arrest accompanied by an increase in p27 protein expression, a protein that regulates the cell cycle.

Lutein combined with other bioactive compounds also exerted a similar effect in inhibiting the prostate cancer cell spreading, but the chemical compound alone did not reproduce the effects of the avocado extract on cancer cell proliferation.

These result strongly indicated, the avocado anti-prostate cancer efficacy probably is associated with all bioactive compounds containing in the fruit such as monounsaturated fat, and carotenoids.

In order to illustrate the importance of the whole fruit in the inhibition of prostate cancer, researchers examined the 3 newly isolated compounds from unripe avocado, and found that all 3 compounds exert significant activity against six human tumor cell lines in culture and show selectivity for human prostate adenocarcinoma (PC-3) cells with 3 being nearly as potent as adriamycin.

Dr. Lu QY, after taking into account other factors said, "Because the avocado also contains a significant amount of monounsaturated fat, these bioactive carotenoids are likely to be absorbed into the bloodstream, where in combination with other diet-derived phytochemicals they may contribute to the significant cancer risk reduction associated with a diet of fruits and vegetables".

Taken altogether, avocado with abundant bioactive active compounds and MUFAs may be considered a functional fruit for the prevention and treatment of prostate cancer, pending to the confirmation of large sample size and multicenter human study.

References
(a) Leung's Encyclopedia of Natural Ingredients: Chemical Composition of Avocado
(1) Associations of whole-blood fatty acids and dietary intakes with prostate cancer in Jamaica by Jackson MD1, Walker SP, Simpson-Smith CM, Lindsay CM, Smith G, McFarlane-Anderson N, Bennett FI, Coard KC, Aiken WD, Tulloch T, Paul TJ, Wan RL. (PubMed)
(2) Inhibition of prostate cancer cell growth by an avocado extract: the role of lipid-soluble bioactive substances. by Lu QY1, Arteaga JR, Zhang Q, Huerta S, Go VL, Heber D.(PubMed)
(3) Cytotoxic and insecticidal constituents of the unripe fruit of Perseaamericana by Oberlies NH1, Rogers LL, Martin JM, McLaughlin JL.(PubMed)
(4) Risk factors for the onset of prostatic cancer: age, location, and behavioral correlates by Michael F Leitzmann1 and Sabine Rohrmann. (PMC)

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