3,3'-Diindolylmethane, the Potential Anti Colon Cancer Bioactive Compound, According to Researchers

By Kyle J. Norton

3,3'-Diindolylmethane or DIM may have a profound and positive effect in reducing risk and treatment of colon cancer, according to studies.

Colon cancer is a chronic condition caused by irregular cell growth in the tissue of the colon.

Most cases of colon cancer start in the cells on the surface of the inner lining of the colon tissue. It is one of most slow-growing cancer that takes years to develop. Therefore, most patients in the early stage of cancer do not experience any symptoms.

However, at the advanced stage, cancer can cause severe rectal bleeding and persistent abdominal pain due to the larger size tumor that has pressed on the nearby nerve cells and blood vessels.

According to the statistics, the risk of CRC increases with age; the median age at diagnosis for colon cancer is 68 in men and 72 in women.

The data of colon provided by CDC showed that every year, 97,000 new cases of colon cancer are diagnosed.

Besides sharing the common symptoms with other types of cancer such as unintended weight loss, loss of appetite, persistent fatigue, and tiredness, patients with colon cancer may also experience symptoms of change of bowel movement, rectal bleeding and persistent abdominal discomforts, such as cramps, gas or pain.

If you experience some of the above symptoms, please make sure you check with your doctor to rule out the possibility.

Although there are many risk factors involved the onset of colon cancer, some researchers suggested aging may be one of the most prevalent risks.

Donna Myers on the examination of the time that needed for a polyp or growth of tissue in the lining  to cancer and the percentage of colon cancer cases in people age 50 or older, said, " By the time colorectal cancer is diagnosed, it has often been growing for several years, first as a non-cancerous polyp and later as cancer. Research indicates that by age 50, one out of four people has polyps".

The results strongly suggested that if you are at the age of 50 and a higher risk of colon cancer, you may want to have a colonoscopy done every 3 years.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

Researchers on finding the natural compounds for the treatment of colon cancer examined the two anti-cancer agents (doxycycline or 3,3'-diindolylmethane) on HCT-116 and HT-29 colon cancer cell lines.

Injection of the 2 compounds resulted in profound changes in the intracellular content of several lncRNAs (by up to 100 times secreted by tumors into the bloodstream.

The results strongly suggested that by examining the levels of lncRNAs colon cancer expression can be monitored through tumor relapse and metastasis.

In order to reveal more information about 3the Sulindac (SU; 320 ppm) effect on colon cancer, researchers examined two natural compounds, 3,3'-diindolylmethane (DIM; 250 ppm) and curcumin (CUR; 2000 ppm), with or without lower doses of SU could affect carcinogenesis.

Colon tumors were significantly reduced by SU 320 ppm (62 % reduction over Controls), by DIM and CUR without or with SU 80 and 160 ppm (50, 53 and 58 % reduction, respectively) but not by SU 80 ppm alone.

Futhermore, total tumors (colon and small intestine) were found to reduce substantially by SU (80 and 320 ppm) and by DIM and CUR.

Apoptosis in the normal mucosa was significantly increased by SU 320 ppm and slightly increased by DIM and CUR with or without SU.

The combination of SU with DIM or Cur also caused a slight reduction in Survivin-Birc5 expression observed with all the treatments compared to controls.

Where Survivin-Birc5 protein is found to inhibit caspases associated with the blocking of cancer cell death. The protein is highly expressed in most cancers associated with a poor clinical outcome.

The results strongly reaffirmed the anti-colon cancer activity of DIM and CUR combination.


Taken altogether, DIM used alone or combined with another bioactive compound may be considered a supplement for the prevention and comn=bined with primary medicine for the treatment of colon cancer, pending to the confirmation of larger sample size and multicenter human study.

Intake of DIM as o form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) [Treatment with anti-cancer agents results in profound changes in lncRNA expression in colon cancer cells].[Article in Russian] by Zinovieva OL1, Grineva EN1, Prokofjeva MM1, Karpov DS1, Krasnov GS1, Prassolov VS1, Mashkova TD1, Lisitsyn NA. (PubMed)
(2) Sulindac, 3,3'-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis by Femia AP1, Soares PV2, Luceri C3, Lodovici M4, Giannini A5, Caderni G. (PubMed)
(3) The Link Between Age and Colorectal Cancer Risk by Donna Myers