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Thursday, 22 November 2018

Thyme Honey Inhibits the Side Effects of Chemo and Radio Therapy in Patients with Head and Neck Cancer

By Kyle J. Norton

Scientists may have found a natural whole food for the treatment of side effects caused by chemo and radio therapy in patients with head and neck cancer with no side effects, according to some studies.

Head and neck cancer is a group of cancers found in the mouth, throat, larynx, sinuses, or salivary glands.

Most cases of head and neck cancer, at the early stage, start by the cell growth irregularly and disorderly on the surface of the inner lining in head and neck.

At the advanced stage, patients may experience symptoms of a lump in the nose, neck or throat, with or without pain, a persistent sore throat that does not heal, trouble swallowing (dysphagia) and frequent and persistent coughing.

At this stage, cancer cells may travel a distance away from the original site to infect other healthy tissue and organs.

Most common head and neck cancer metastases are secondary skin cancer.

The exact causes of head and neck cancer are unknown. researchers cannot explain why people with similar health conditions and the same risk factors, some are susceptible to the onset of the disease, while others do not,

However, certain prevalent risk factors such as prolonged sun exposure, infected by the  Human papillomavirus (HPV) and  Epstein-Barr virus (EBV), poor oral and dental hygiene and occupational inhalants, long-term marijuana, and tobacco use and involuntary smoking are associated to the onset of head and neck cancer.

Dr. Yuan-Chin Amy Lee, the lead author in the study "Involuntary Smoking and Head and Neck Cancer Risk" suggested that involuntary smoking one of the major risk factor associated with the head and neck cancer has not drawn much interest in health practitioners.

According to the Involuntary smoking exposure data pooled across six case-control studies in Central Europe, Latin America, and the U.S. Adjusted odds ratios (OR) including 542 cases and 2197 controls who reported never using tobacco, long duration of involuntary smoking exposure at home and at work was associated with an increased risk (OR for >15 years at home: 1.60; 95%-CI 1.12, 2.28; for trend <0.01; at work: 1.55; 95%-CI 1.04, 2.30; p for trend 0.13).

Particularly, there is an association between pharyngeal and laryngeal cancers and involuntary smoking exposure observed for long duration of exposure.

Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

On finding a natural ingredient to reduce serious side effect caused by chemo and radiotherapy in the treatment of neck and neck cancer, researchers conducted a joint study led by the at the Cyprus University of Technology to examine the effect of honey on Radiation-induced xerostomia.

The parallel randomized controlled trial included 2 equal arms, the experimental arm (thyme honey) and the control arm (saline).
72 head and neck cancer patients receiving radiotherapy or/and chemotherapy or/and surgery recruited in a specialized cancer center are included in the study.

Patients in both arms followed the same administration protocol with thyme honey and saline respectively was assessed at baseline, 1 month and 6 months following completion of the intervention.

Thyme honey treatment group displayed a statistically significant effect of the intervention on xerostomia (F = 8.474 p < 0.001) and overall quality of life, compared to the control.

Furthermore, thyme honey treatment group also showed to maintain their body weight and showed an improve their global health (p = 0.001) compared to the control group.

The Generalised Estimating Equations also revealed a statistically significant effect on strong and unbearable pain in the thyme honey treatment group.

Additionally, in the concerns of side effect of oral mucositis induced by radiation-induced after the treatment of head and neck cancer patients, researchers at the Cyprus University of Technology also conducted a similar study to evaluate the effectiveness of thyme honey on oral mucositis management.

72 head and neck cancer patients participated in the randomized controlled trial (RCT) with were divided either into the intervention group (thyme honey rinses) or to the control group (saline rinses), starting at the 4th week of the radiotherapy for seven weeks and repeated once 6 months later.

Thyme honey treatment group demonstrated a reduced grade of oral mucositis in compared to control, according to the Generalized estimating equations.

The treatment group also showed a similar effect as of the previous study in maintaining their body weight (p < 0,001) and improving their global health (p = 0.001) compared to the control group.

Most importantly, thyme honey treated group showed a significant improvement of the quality of life which was not found in the control group.

Dr. Charalambous M, the lead author said, "(Our) study provided evidence on the positive effect of thyme honey on the management of radiation-induced oral mucositis and quality of life in head and neck cancer patients:

Taken altogether, thyme honey may be considered a functional food for the treatment and management of side effects induced by the chemo and radiotherapy in patients with head and neck cancer.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.


Sources
(1) The effectiveness of thyme honey for the management of treatment-induced xerostomia in head and neck cancer patients: A feasibility randomized control trial by Charalambous A1, Lambrinou E2, Katodritis N3, Vomvas D3, Raftopoulos V2, Georgiou M3, Paikousis L4, Charalambous M. (PubMed)
(2) The effect of the use of thyme honey in minimizing radiation - induced oral mucositis in head and neck cancer patients: A randomized controlled trial by Charalambous M1, Raftopoulos V2, Paikousis L3, Katodritis N4, Lambrinou E2, Vomvas D4, Georgiou M4, Charalambous A. (PubMed)
(3) Involuntary Smoking and Head and Neck Cancer Risk, Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium by Yuan-Chin Amy Lee,1 Paolo Boffetta,1 Erich M. Sturgis,2 Qingyi Wei,2 Zuo-Feng Zhang,3Joshua Muscat,4 Philip Lazarus,4 Elena Matos,5 Richard B. Hayes,6 Deborah M. Winn,6David Zaridze,7 Victor Wünsch-Filho,8 Jose Eluf-Neto,8 Sergio Koifman,9 Dana Mates,10Maria Paula Curado,11 Ana Menezes,12 Leticia Fernandez,13 Alexander W. Daudt,14Neonila Szeszenia-Dabrowska,15 Eleonora Fabianova,16 Peter Rudnai,17 Gilles Ferro,1Julien Berthiller,1 Paul Brennan,1 and Mia Hashibe. (PMC)

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