Curcumin, the Kitchen Spice Which is Also A Potent Anti Non-alcoholic Fatty Liver Disease (NAFLD) Remedy, Scientists Say

By Kyle J Norton, Master of Nutrition

Scientists may have discovered a potent natural ingredient for the prevention and treatment of Nonalcoholic Fatty liver disease (NAFLD) without inducing any side effects, some studies suggested.

Non-alcoholic fatty liver disease is a condition of liver disorder caused by the accumulation of fat, other than abusive alcohol consumption.

Although the condition may not be dangerous in the early stage. However, as the condition progresses, NAFLD will develop nonalcoholic steatohepatitis (NASH). At the advanced stage, nonalcoholic fatty liver disease (NAFLD) can develop into cirrhosis, the major risk factor of liver cancer scarring and dysfunction of the liver.

Although researchers do not know the exact cause of nonalcoholic fatty liver disease (NAFLD), they do know that certain risk factors are associated with the early onset of the disease, including obesity, starvation and protein malnutrition, long-term use of total parenteral nutrition, intestinal bypass surgery for obesity, rapid weight loss.

Certain medical conditions such as hyperlipidemia (elevated lipids in the blood), insulin resistance and high blood pressure. genetic preposition and long-term use of medication are also the prevalent risk factors of the disease onset.

Sadly, according to the statistic provided by the liver foundation, more than 50% of Canadians are overweight. 75% of obese individuals are at risk of developing a fatty liver and  23% of obese individuals are at risk of developing fatty liver with inflammation.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.. Curcumin is one of the natural phenols in the plant.

In the findings of natural ingredients from herbal medicine for the treatment of liver diseases with no side effects, researchers at the GENyO Center Pfizer-University of Granada & Andalusian Government Centre for Genomics & Oncology launched an investigation to examine the effect of curcumin for the management of liver-related diseases.

In combating liver diseases, curcumin showed a significant activity in exerting the hypolipidic effect, which prevents the fatty acid accumulation in the hepatocytes, causing metabolic imbalances, the major cause of nonalcoholic steatohepatitis.

In the protective activity, curcumin, not only demonstrates an effect in the context of chronic liver diseases but also inhibits the carcinogenesis and age-related processes, through is its potent antioxidant activity. 

Furthermore, curcumin also acts on NF-κβ in the prevention of liver cell death and cell alteration.

NF-κβ is a protein which controls transcription of DNA, cytokine production and cell survival.

These result suggested that curcumin is a liver protective micronutrient, closely related to cellular redox balance.

Further evaluation of the curcumin derivative on non-alcoholic steatohepatitis (NASH) rats, researchers at The Second Affiliated Hospital of Chongqing Medical University conducted a study on rat induced by high-fat diet combined with carbon tetrachloride.

All mice are randomly divided into 5 group. After injection with carbon tetrachloride, these rats were then treated with curcumin and curcumin derivative, with the saline treating group as control.

Rats treated with curcumin derivatives showed a remarkable reduction in serum ALT (U/L), AST (U/L) and TC (mmol/L), compared to the saline group,

Curcumin derivative group also exerts a decrease of fibrosis, liver index and serum ALT, AST.

The liver steatosis and inflammation grade were also significantly improved

Dr.Zeng CH, the lead author at the final report said, " the water-soluble curcumin derivative displays superior bioavailability to the parent curcumin, which can effectively improve the lipid metabolism and delay the progression of hepatic fibrosis in rats with steatohepatitis".

Taken altogether, curcumin, a kitchen spice may be considered a functional food and an adjunct therapy for the prevention and treatment of non-alcoholic fatty liver disease without inducing any side effects.

However, additional data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of Curcumin anti-on-alcoholic fatty liver disease possibilities.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Curcumin and liver disease.Vera-Ramirez L, Pérez-Lopez P, Varela-Lopez A, Ramirez-Tortosa M, Battino M, Quiles JL.(PubMed)
(2) [The effects of curcumin derivative on experimental steatohepatitis].[Article in Chinese] by Zeng CH, Zeng P, Deng YH, Shen N, Peng ML, Liu Q, Ren H.(PubMed)