The Vegetable Juice Which Stops Leukemia Cells From Spreading, Researchers Found

Kyle J. Norton

Carrots may have a profound and positive impact in inhibited lymphoid leukemia cells from cell cycle division, some scientists suggested.

Leukemia is a medical condition characterized by the abnormal growth of the cells in the blood.

Lymphoid leukemia cells are the abnormal cell developed of cancerous cells from early (immature) forms of lymphocytes, a type of white blood cell.

The Leukemia and Lymphoma Society in 2018 statistic report wrote, "Approximately every 3 minutes one person in the United States (US) is diagnosed with a blood cancer. ... New cases of leukemia, lymphoma, and myeloma are expected to account for 10 percent of the estimated 1,735,350 new cancer cases diagnosed in the US in 2018".

The disease affects mostly people aged 55 and over, however, it is also the most common cancer in children under 15 years of age.

There is no single cause of abnormal blood cells that do not die but accumulate and proliferate.

Some researchers suggested that use artificial ionizing radiation, infected by human T-lymphotropic virus (HTLV-1) and HIV, long-term contacted with benzene and some petrochemicals, medication used for the treatment of cancer, gene alternation and certain diseases such as Down syndrome are associated to increased risk of immature white blood cells development.

Frequent use of hair dyes and long-term and heavy smoking are also considered as preventable risk factors that cause leukemia.

Most common symptoms are pains in the bones or joints, swollen lymph nodes, fevers or night sweats,  bleeding and bruising easily, frequent infections, discomfort or swelling in the abdomen and general cancer symptoms of weight loss, loss of appetite, feeling weak or tired.

If you experience some of the above symptoms, please check with your doctor immediately, you may be at the early stage of leukemia.

Carrot, a root vegetable with an orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

In a study conducted by the Sheffield Hallam University to exam the potential effects of  injection of carrot juice in treatment of the 3 three lymphoid leukaemia cell lines and to test the suggestion of traditional medicine regarded to the used of carrot for potential treatment for leukaemia by using carrot the bioactive compounds such as three polyacetylenes (falcarinol, falcarindiol, and falcarindiol-3-acetate) and two carotenoids (beta-carotene and lutein) isolated from carrot juice extract (CJE) researchers found that

* Application of carrot juice exerts a significant effect in the induction of cancer cell apoptosis observed by the Annexin V/PI and Caspase 3 activity assays.

* Injection of carrot contained polyacetylenes and carotenoids in leukemia cell lines with the fraction from carrot extracts was significantly more cytotoxic in compared to other fractions.

* Treatment with purified polyacetylenes isolated from carrot juice also induced apoptosis, but in a dose and time responsive manner. 

*  Falcarinol and falcarindiol-3-acetate isolated from Daucus carota L induced a most significant cytotoxic activity in compared to falcarindiol.

Surprisingly, in contrast, the carotenoids, the major bioactive compound found abundantly in carrot demonstrated the insignificant effect on either apoptosis or cell proliferation in all tested cell line.

These result illustrated a strong message that the efficacy of carrot in the treatment of was attributed to chemical compound polyacetylenes rather than beta-carotene or lutein as hypothesized by some literature.

Further analysis also suggested that the cytotoxic effects of polyacetylenes were most efficacy in facilitated apoptosis and inhibited proliferation through the arrest of the cell cycle. 

Additional investigation of carrot juice extract against expression of on myeloid and lymphoid leukemia cell lines in compared to normal hematopoietic stem cells also conducted by the same institute, suggested that treatment of carrot juice extracts for up to 72 hours in vitro display a strong effect in induction of cancer cells death observed by the annexin V/propidium iodide staining followed by flow cytometric analysis.

Furthermore, in compared to normal cell lines, injection also inhibited the progression of the cancer division through the cell cycle arrested observed by the cell cycle analysis and cell counts.

Interestingly, application of the extract exerted a higher inhibitory effect in lymphoid cell lines in compared to myeloid cell lines, without affecting the normal and healthy hematopoietic stem cells.

Finally, after taking into account of other co and confounders, Dr. said, "extracts from carrots can induce apoptosis and cause cell cycle arrest in leukemia cell lines. The findings suggest that carrots may be an excellent source of bioactive chemicals for the treatment of leukemia ".

The found evidence suggested that carrot juice and its bioactive compound polyacetylenes may be considered as functional foods for ameliorated risk, progression, and treatment of lymphoid leukemia.

However, further data collection on large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of carrot juice anti-leukemia possibilities.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Effects of bioactive compounds from carrots (Daucus carota L.), polyacetylenes, beta-carotene and lutein on human lymphoid leukaemia cells by Zaini RG1, Brandt K, Clench MR, Le Maitre CL.(PubMed)
(2) Bioactive chemicals from carrot (Daucus carota) juice extracts for the treatment of leukemia by Zaini R1, Clench MR, Le Maitre CL. (PubMed)
(3) Effects of carrot and tomato juice consumption on faecal markers relevant to coloncarcinogenesis in humans by Schnäbele K1, Briviba K, Bub A, Roser S, Pool-Zobel BL, Rechkemmer G.(PubMed)