The Root Veggie That Inhibits Immune-Mediated, Cardiovascular, Infectious,....and Systemic Inflammatory Diseases Caused By Thrombosis

Kyle J. Norton

Carrots may have a profound and positive effect in reduced risk and complications of thrombosis some scientists suggested.

The results of the analysis were reported in the online literature conducted by numbers of universities including Kobe Gakuin University.

You can view the abstract from the studies by clicking any link at the resources data.

Thrombosis is a medical condition characterized by the formation of a blood clot inside a blood vessel, obstructing the flow of blood in the circulatory system.

Thrombosis is considered  a common cause of atherosclerosis.

The 2 major types of thrombosis are
* If the blood clot blocks a vein, it is classified as venous thrombosis.

 Veins are blood vessels that carry blood from the body back into the heart.
* If the blood clot blocks an artery, it is arterial thrombosis.
Arteries are the blood vessels that carry oxygen-rich blood away from the heart to the body.

The actual causes of thrombosis are debatable. However, some researchers suggested that diseases or conditions of the leg veins, immobility due to physical incapability,  bone fracture, obesity,... and genetic mutation of certain genes are associated to the causes and risks of thrombosis.

Importantly, certain medications such as Apixaban, Dabigatran, Edoxaban, Heparin. Rivaroxaban ..... and Warfarin and birth control pills containing the hormones desogestrel, gestodene, drospirenone, and cyproterone are also considered as risk factors of thrombosis.

Risks of deep vein thrombosis (DVT) and pulmonary embolism (PE), are increased substantially in pregnant women, especially in women who have an inherited clotting disorder.

Diseases associated to include immune-mediated disease, systemic inflammatory, cardiac,.......and infectious diseases.

Carrot, a root vegetable with an orange color is a sub species of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

In the investigation to find a daily diet with proven antithrombotic effects in reduced risk of acute thrombotic event researchers at the Kobe Gakuin University launched a study to examine vegetables and fruits for antithrombotic activity.

The vegetables included 15 different varieties of carrot using ashear-induced in vitro platelet reactivity/thrombolysis method, Global Thrombosis Test, formerly Gorog Thrombosis Test.

According to the differentiation of the antiplatelet and thrombolytic activities, researchers showed that
* Different carrot varieties demonstrate a variable effect on thrombosis in vitro and in vivo.

* In laser-induced thrombosis model in mice, heat treatment of carrot variety
exerts an antithrombotic effect independent from heat treatment of the filtrate at 100 degrees C for 10 min.

* In oral intake, the particular heat resistant variety (SAKATA-0421) shows an antithrombotic effect in vivo possibly due to antiplatelet reactivity and/or spontaneous thrombolytic activity.

Interestingly, the expression of antithrombotic activity showed no significant correlation between antithrombotic activity and the levels of polyphenolics and any other biochemical parameter, including antioxidant activity, alpha-carotene and beta-carotene, alpha-tocopherol and ascorbic acid

These results suggested that carrot demonstrated strong impacts in reduced blood clot accumulation regardless to the effect of individual ingredients. 

Dr. Yamamoto J, the lead author said, "An inappropriate diet is known to enhance the risk for acute thrombotic events and a regular diet with proven antithrombotic effects( including carrots) might be a beneficial way to prevent disease" and "the present study added a new variety to the list of antithrombotic fruits and vegetables".

Further analysis of the tissue linked to the development of cardiovascular disease due to endothelial activation in the induction of thrombosis of blood vessels, researchers at the Comanche County Memorial Hospital launched an investigation to evaluate the effect of diet-derived antioxidants in suppressed and/or delayed progression of cardiovascular disease.

The suggestions of water-dispersible forms of various carotenoids (beta-carotene, lutein and lycopene) from natural sources in microemulsion were recommended to study the effects of carotenoids on tissue factor activity in human endothelial cells.

According to the differentiation, all carotenoids suppressed tissue factor activity (P<.01) and gene expression in human endothelial cells which may have a strong effect in the contribution of the development of blood clot in the vessels.

Endothelial cells in the endothelium have an essential effect in regulate vascular tone, cellular adhesion, smooth muscle cell proliferation, and vessel wall inflammation. 

Moreover, application of carotenoids also enhanced phosphorylation of Akt activity in human endothelial cells on tissue factor activity in regulation of thrombosis of blood vessels.

After taking into account of other co and con founders, Dr. Lee DK, the lead scientist said, "diet-derived antioxidants might suppress and/or delay progression of cardiovascular disease (through regulating endothelial activation in the expression of thrombosis of blood vessels)".

The findings suggested that carrot and its bioactive carotenoids may be considered as functional food in reduced formation of blood clot in the vessels in the induction of cardiovascular diseases.

However, intake of supplementation should be taken with extreme care as acute liver toxicity was reported in numbers of the case in medical literature.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) The antithrombotic effects of carrot filtrates in rats and mice by Yamamoto J1, Naemura A, Ijiri Y, Ogawa K, Suzuki T, Shimada Y, Giddings JC(PubMed)
(2) Carotenoids enhance phosphorylation of Akt and suppress tissue factor activity in human endothelial cells by Lee DK1, Grantham RN, Mannion JD, Trachte AL(PubMed)