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Tuesday, 3 July 2018

Detoxification: How to Detox and Nourish Your Immune System, Brain, Liver, Kidney, Skin, Lung and Blood For Optimal Health, Citations Provided By NIH

By Kyle J. Norton, Scholar, Master of Nutrition

Western diet contains high saturated fat, trans fat, and other harmful substances such as sugar, caffeine, pesticides, additive substances, and less in fruits and vegetables.

These types of harmful substances are toxic. 

Detoxification is a natural process of our body to maintain the proper function and protect our organs and tissues against toxicity by eliminating toxins accumulated.

When they fail,  the toxic accumulations cause a disruption of hormone production, damage the  body's detoxification organs and weaken the immune system, leading to hormone imbalance and many chronic illness consequently.

Some researchers suggested that over expression of toxins may lead to imbalance of the ratio of free redicals and antioxidants produced by the antioxidant enzymes of tissue, leading to oxidative stress in induction of cytotoxicity.

Cytotoxicity not only damage healthy cells but also alternates cells DNA transcription, one of major cause of cancer.

The natural remedies detox and nourish your Immune system, Brain, Liver, Kidney, Skin, Lung and Blood include

1. Garlic extract
Garlic extract is a widely used medication in the world with proven record in preventing and treating heart disease, increasing circulation of blood flow, protecting our kidney and liver against injure and damage caused by ROS inducing cytotoxicity.

According to a 2009 study by Tabriz University of Medical Sciences, application of garlic extract in tested mice reserved liver toxicity caused by overdosed on acetaminophen in induction of oxidative stress and depletion of the host antioxidants, such as glutathione (GSH)(1).

Dr. Anoush M, the lead scientist said, "Acetaminophen, the most commonly sold over-the-counter antipyretic analgesic, is capable of causing severe and sometimes fatal hepatic damage in humans and experimental animals".

The herb also strengthen our system's fighting against the degeneration of our body.

2. Gotu Kola
Gotu Kola is also known as cetenlla asiatica with a strong effect in treating nervous system disorder caused by inflammation, and improving alertness and memory.

According to the Inha University Hospital, application of leaf extract exerted a significant activity in reduced oxidative stress induced by injection of dimethylnitrosamine‑induced liver injury in rats(2).

The results of these actions were attributed to the extract in significantly decreased the level of malondialdehyde and increased the levels of host antioxidant enzymes, including superoxide dismutase, glutathione peroxidase and catalase, and may have provided protection against the deleterious effects of reactive oxygen species.

In metal toxins accumulation by arsenic exposure (20 ppm in drinking water for 4 weeks) injection in tested rats, application of oral supplementation of Centella asiatica (100, 200 or 300 mg kg(-1), orally once daily displayed a string inhibition of delta-aminolevulinic acid dehydratase (ALAD) activityin induction of increased oxidized glutathione (GSSG) and thiobarbituric acid reactive substance (TBARS) levels(3).

Over expression of ROS can lead to liver, kidney and brain damage permanently(3).

These result suggested that Gotu Kola anti toxins in the liver, kidney and blood effect(13) may be considered as a co-administration during chelation therapy with a thiol chelator(3).


With enormous antioxidant property, gotu kola can also rejuvenate the body against the forming of free radicals in induced early aging.

3. Astragalus
Astragalus  are used in traditional Chinese medicine for strengthening our body in fighting against diseases and protecting cells from free radicals through it antioxidants activty.

The herbal medicine also is an excellent agent in fought against virus and bacteria, and restored our body's energy.

According to the Institute of Clinical Pharmacology, Anhui Medical University, extract isolated from the roots of P. lactifloruala and A. membranaceus demonstrated better hepatoprotective activity in compared to application of individual herb used seperately(4), through antioxidant activity.

Furthermore, injection in animal model suggested that astragalus saponin extracts (AS) process a strong kidneys protective on diabetic rats(5). through reduction of renal pathological changes.

4. Bee Pollen

Bee pollen is said to contain all the essential components of life.

Accoridng to traditional herbal medicine, the herb process tonified activity by correcting the deficient, re balanccing nutrition and improving our immune system as well as rejuvenating our body.

In concerns of Cisplatin (CP), after application to patient with an aim to cure cancers although it is effectively in clinics, however, it could induce toxic effects, researchers at the Fujian Agriculture and Forestry University, conducted an experiment to test whether bee pollen, a natural compound, produced by honey bees has a potential inhibited expression of these toxic effects(6).


The results are so astonishingly, application of bee pollen extract (SCBPE) reversed the damage of liver and kidney caused by Cisplatin (CP) through improving the antioxidant, anti-inflammatory and anti-apoptotic capacity of the body.

Moreover, antioxidant rich bee polen also demostrated a strongly preventive effect against histological changes in the liver and cardiac blood vessels, abnormalities of lipid profile, and the levels of oxidized low density lipoproteins (ox-LDL), asymmetric dimethylarginine (ADMA), angiotensin-converting enzyme (ACE), and angiotensin II (ANG II) caused by a high-fat diet in C57BL₆ mice(7).



5. Dock
Dock contains vitamin C and vitamin A. 
The herbal medicine not only promotes a strong immune system, but also dissolves heavy metalaccumulated in our body and prevents muscular degeneration.

According to the Xi'an Jiaotong University Health Science Center, dihydromyricetin (DHM), a bioactive flavonoid component isolated from dock against lung injure and damage caused by injection of LPS(8).

6. Reishi Mushroom

Reishi Mushroom contains ganoderic acids with function in strengthening our immune system's fight against inflammation.

In the study to evaluate the antioxidative effect of hot water extract of the mushroom Ganoderma lucidum on ethanol-induced free radical generation, researchers at the Taipei Medical University Hospital showed that injection of the extract on dose-dependently exhibited antioxidative effect on mouse liver and kidney lipid peroxidation(9).

At the final report, Dr. Shieh YH, the lead scientist said, "the hepatic and renal protective mechanism of Ganoderma lucidum, might be due at least in part to its prominent superoxide scavenging effect. Ganoderma extract could protect the liver and kidney from superoxide induced hepatic and renal damages".

The hot water extracts also was shown to have antioxidative effect against heart and chemical toxicity(12), according to the Mackay Memorial Hospital(10).

Furthermore, the mushroom polysaccharides protect skin fibroblasts against UVB-induced photoaging(11)..



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Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) The protective effects of garlic extract against acetaminophen-induced oxidative stress and glutathione depletion by Anoush M1, Eghbal MA, Fathiazad F, Hamzeiy H, Kouzehkonani NS(PubMed)
(2) Protective effects of Centella asiatica leaf extract on dimethylnitrosamine‑induced liver injury in rats by Choi MJ1, Zheng HM1, Kim JM2, Lee KW3, Park YH3, Lee DH(PubMed)
(3) Effect of Centella asiatica on arsenic induced oxidative stress and metal distribution in rats by Gupta R1, Flora SJ(PubMed)
(4) Protective effect of extract from Paeonia lactiflora and Astragalus membranaceus against liver injury induced by bacillus Calmette-Guérin and lipopolysaccharide in mice by Sun WY1, Wei W, Gui SY, Wu L, Wang H(PubMed)
(5) [Protective effect of astragalus saponin extracts on kidneys of diabetic rats].[Article in Chinese] by Xiao F, Hu YG, Wu SN, Shou QY, Cai YQ, Wang HM, Wang H(PubMed)
(6) Protective effect of Schisandra chinensis bee pollen extract on liver and kidney injury induced by cisplatin in rats by Huang H1, Shen Z1, Geng Q2, Wu Z2, Shi P3, Miao X(PubMed)
(7) Protective Effect of Polyphenol-Rich Extract from Bee Pollen in a High-Fat Diet by Rzepecka-Stojko A1, Kabała-Dzik A2, Kubina R3, Jasik K4, Kajor M5, Wrześniok D6, Stojko J(PubMed)
(8) Protective effect of dihydromyricetin on LPS-induced acute lung injury by Wang B1, Xiao Y1, Yang X1, He Y1, Jing T1, Wang W2, Zhang J3, Lin R(PubMed)
(9) Evaluation of the hepatic and renal-protective effects of Ganoderma lucidum in mice by Shieh YH1, Liu CF, Huang YK, Yang JY, Wu IL, Lin CH, Li SC(PubMed)
(10) Antioxidant activity of Ganoderma lucidum in acute ethanol-induced heart toxicity by Wong KL1, Chao HH, Chan P, Chang LP, Liu CF(PubMed)
(11) Antioxidant activity of Ganoderma lucidum in acute ethanol-induced heart toxicity by Wong KL1, Chao HH, Chan P, Chang LP, Liu CF.(PubMed)
(12) Protective effect of vanilloids against chemical stress on the white-rot fungus Ganoderma lucidum by Kuhar F1, Papinutti L(PubMed)
(13) Effects of some thiol chelators on enzymatic activities in blood, liver and kidneys of acute arsenic (III) exposed mice by Tripathi N1, Flora SJ(PubMed)


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