How to Prevent Leukemia Naturally and Effectively, PubMed Medical Studies Revealings

Kyle J. Norton

Adding a portion of carrots in your daily diet may have a profound and positive effect in prevent onset of leukemia, some scientists suggested.

Leukemia is progressive cancer characterized by bone marrow and other blood-forming organs in produced increased numbers of immature or abnormal leukocytes, thus suppressing the production of normal blood cells.

Leukemia is of the major cause of anemia.

The results of differentiation were conducted by several respectable universities, including Lebanese American University and Sheffield Hallam University and published on online medical literature, including Medline.

Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

Nutrients
1. Carbohydrates
2. Sugars
3. Fibre
4. Fat
5. Protein
6. Vitamin A
7. Thiamine (VittaminB1)
8. Riboflavin (Vittamin B2)
9. Niacin (Vittamin B3)
10. Vitamin B6
11. Folate (Vittamin B9)
12. Vitamin C
13. Vitamin K
14. Calcium
15. Iron
16. Magnesium
17. Molybdenum
18. Phosphorus
19. Potassium
20. Sodium

In the evaluation of the effect of Daucus carota oil extract (DCOE) in target acute myeloid leukemia (AML) cell lines, researcher at the Lebanese American University, found that application of carrot extract exerts a significant activity in inhibited all the AML cell lines while expressing no effect in tested peripheral mononuclear cells.

Peripheral blood mononuclear cells (PBMC) are blood cells with round nuclei formed an important part of immune system components, including lymphocytes (T cells, B cells and NK cells) and monocytes. The mononuclear cells are commonly used in research on immune disorders, cancer and viral diseases.......

The inhibition of AML cell death observed by annexinV found that application of carrot oil extract restored the viability of healthy cells found in the acute myeloid leukemia (AML) cell lines but induces apoptotic cell death in AML through cytotoxicity

Dr. Tawil M, the lead scientist said, "DCOE induces selective apoptosis in AML cells, possibly through a MAPK-dependent mechanism".

Mitogen-activated protein kinases (MAPKs) are family of serine/threonine protein kinases with strong effect in regulated cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival.

In further confirmation of carrot effect in inhibited leukaemia, five fractions from carrot juice extract (CJE) were tested on human lymphoid leukaemia cell lines, including 3 polyacetylenes (falcarinol, falcarindiol and falcarindiol-3-acetate) and 2 carotenoids (beta-carotene and lutein).

According to the Annexin V/PI and Caspase 3 activity assays and Cell Titer Glo assay and cell cycle analysis,
* Injection of carrot extracts which contained polyacetylenes and carotenoids was significantly more cytotoxic in all three lymphoid leukaemia cell linesthan the 4 other fractions.

* Treatments with purified polyacetylenes also induced apoptosis in a dose and time responsive manner.

* Falcarinol and falcarindiol-3-acetate isolated from Daucus carota L were more cytotoxic in compared to falcarindiol

* Interestingly, the carotenoids treatment showed no significant effect on either apoptosis or proliferation in any of the tested cell lines.

These results suggested that carrot processed anti leukemia through induction of cell apoptosis via cytotocity and cell cycle arrest was attributed to the contents of polyacetylenes rather than beta-carotene or lutein.

Additionally, in the study of carrot juice extract effect against leukemia cells, researchers at the Sheffield Hallam University found that on myeloid and lymphoid leukemia cell lines together with normal hematopoietic stem cells, injection of carrot juice extracts to 72 hours induces apoptosis and inhibited progression through the cell cycle.

In classification of types of cell line, also indicated that lymphoid cell lines are affected to a greater extent in compared to myeloid cell lines. Application of the extract showed no effect on normal hematopoietic stem cells.

The experiment strongly suggested that carrot juice extract significantly induces apoptosis and causes cell cycle arrest in leukemia cell lines without harming to the healthy nearby cells.

Taken together, carrot and its extract may be considered as potent and therapeutic therapies for prevention of leukemia.

However, intake of carrot supplement should be taken with extreme care in prevention of acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Effects of bioactive compounds from carrots (Daucus carota L.), polyacetylenes, beta-carotene and lutein on human lymphoid leukaemia cells by Zaini RG1, Brandt K, Clench MR, Le Maitre CL.(PubMed)
(2) Bioactive chemicals from carrot (Daucus carota) juice extracts for the treatment of leukemia.
Zaini R1, Clench MR, Le Maitre CL(PubMed)

(3) Wild carrot oil extract is selectively cytotoxic to human acute myeloid leukemia cells BY Tawil M1, Bekdash A, Mroueh M, Daher CF, Abi-Habib RJ.(PubMed)