Herbal Therapy: Arnica, A Potent Function Herb in Reduced Risk, Progression and Treatment of Inflammatory Arthritis

Arnica may have substantial and therapeutic values in reduced risk, progression and treatment of inflammatory arthritis, some scientists suggested.

The results of these efficacy were reported by numbers of respectable institutes and published on online medical literature, including  the University of Medicine and Pharmacy and University of Mauritius.

Arthritis is a chronic condition characterized by inflammation of more than one joint.

According to the statistic, rheumatoid arthritis, one of common type of arthritis, is a chronic disease affecting over 1.3 million Americans and at least 1% of the worldwide population.

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, antive to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is process of repairing after damage of skin, tissues, organs, etc.


The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative.

In the finding of a natural source of alternative agent in replaced the conventional medication (ranging from pain-killers to biological agents) is potent, but frequently associated with serious, even life-threatening side effects, researchers at the joint study conducted by the University of Medicine and Pharmacy, found that Arnica montana is found effective in at least in studies done in vitro or on animal models.

Other researchers also in the searching of the same by looking into the major scientific databases; Google Scholar, Pubmed, ScienceDirect, and Scopus were explored to highlight novel therapeutic approaches using herbal products for CAIDs prophylaxis, management, treatment, and prevention of relapse found that herbal products, including Arnica can act on multiple targets involved in the pathogenesis.

In compared to other herbal and antioxidants used in the experienment, Arnica demonstrated a significant activity in improved pain and physical function in patients suffering from osteoarthritis 

Further analysis suggested that Arnica alleviated pain in patients with osteoarthritis was associated to reduce over immune over response in production of pro inflammatory factors to the site of infection in facilitated damage and cell of the joint through its anti inflammatory effects.

Some researchers postulated that Arnica may also reduce joint inflammation through the expression of the plant antioxidants and stimulation of the antioxidants in the host tissue, thus decreasing the risk of imbalance of the ratio of reactive oxygen species and antioxidant in precipitation of the symptoms and progression of osteoarthritis.

Dr. Mahomoodally F, the lead author after taking into account of other co and con founders, said, " In silico approaches remain also a pertinent avenue to unveil highly compatible herbal metabolites binding multiple targets involved in inflammation".

More importantly, in the animal modles to investigate the therapeutic effects and mechanism of action of A. montana flower methanol extract (AMME) against both inflammation and oxidative stress in a collagen-induced arthritis (CIA), scienntists showed that application of montana flower methanol extract (AMME) exerted significant activities against both inflammation and oxidative stress in a collagen-induced arthritis (CIA).

Additional differentiation found that oral administration of AMME was found to reduce clinical signs and improve the histological and radiological status of the hind limb joints by ameliorated the expression levels of nitric oxide, tumor necrosis factor-α, interleukins (IL-1β, IL-6 and IL-12) and titer of anti-type II collagen antibody compared with untreated CIA rats. 

Nitric oxide (NO) is an enzyme involved in the induction of inducible type-2 isoform of nitric oxide synthase (NOS-2), in activated toxic defense molecule against infectious organisms, however, over production of NO may cause cells damage and apoptosis at the site of infection.

Tumor necrosis factor-α, interleukins (IL-1β, IL-6 and IL-12) are all proinflammatroy cytokines produced by immune system to protect cell in the infection against invasion of micro organisms. Over expression was also associated to risk of cell damage and apoptosis.

High levels of type II collagen antibody is one of biomarkers associated with concurrent but not later signs of inflammation.

Dr. Sharma S, at the end of the experiment said, " by inhibiting these mediators, AMME also contributed towards the reversal of disturbed antioxidant levels and peroxidative damage".

Taken together, Arnica and its bio extracts may be considered as a functional food in reduced risk, progression and treatment of inflammatory arthritis without inducing intolerant adverse effects

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Cumulative therapeutic effects of phytochemicals in Arnica montana flower extract alleviated collagen-induced arthritis: inhibition of both pro-inflammatory mediators and oxidative stress by Sharma S1, Arif M1, Nirala RK1, Gupta R2, Thakur SC1.(PubMed)
(2) Phytomedicine in Joint Disorders by Dragos D1,2, Gilca M3, Gaman L4, Vlad A5, Iosif L6, Stoian I7,8, Lupescu O(PubMed)
(3) Herbal products for common auto-inflammatory disorders - Novel approaches by Mahomoodally F1, Suroowan S1(PubMed)