Herbal Therapy: Herbal Anise in Ameliorated Risk and Treatment of Functional Dyspepsia

Kyle J. Norton 


Anise may have a potential and substantial effect in reduced risk and treatment of functional dyspepsia (FD), some scientists suggested.

Anise is a flowering plant ofthe species of Pimpinella anisum, genus Pimpinella, belonging to the family Apiaceae native to to Egypt and the Mediterranean region,  used in traditional herbal medicine as fragrance in soaps, oils, and mouth fresheners and stomachic, anti-septic, anti-spasmodic, ....

Chemical comstituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.

Functional dyspepsia (FD) is a chronic disorder characterized by sensation and movement (peristalsis) in the upper digestive tract.

In the study of total of 180 patients attending the gastroenterology clinic, 107 ones with the diagnosis of postprandial distress syndrome according to Rome III criteria, randomly assigned to anise group of 47 patients received anise powders, 3 g after each meal (3 times/day) for 4 weeks and placebo group of 60 patients received placebo powders (cornstarch), 3 g after each meal (3 times/day) for 4 weeks researchers at the joint study lead by the Iran University of Medical Sciences indicated that

Anise treatment scored a significant improvement of all domains of SF-36(The Short Form (36) Health Survey) at week 12 in compared to placebo group, although both groups scored a similar at the baseline.

More specifically, at week 12, the mean of physical component score was 141 in placebo group and 251 in Anise treatment group in compared to the base line scores of 159 and 167, respectively and the mean mental component scores at weeks 12 was 135 in placebo group and 233 in anise group in compared to 172 and 165 respectively.

Domain of SF-36  completed by the patients includes vitality, physical functioning, bodily pain, general health perceptions, physical role functioning, emotional role functioning, social role functioning, and mental health,  used widely in managed care organizations and  medicare for routine monitoring and assessment of care outcomes in adult patients. The lower the score is an indication of more disability in compared the higher the score of less disability.

The strong improvement of physical and mental scores in the Anise group in compared to the base line and placebo may be associated to Anise in contributed to increase quality of life in patients of functional dyspepsia, through reduction of symptoms intensity.

Further differentiation, in a total of 107 patients attending the gastroenterology clinic, aged 18-65 years, diagnosed with PDS according to ROME III criteria, randomly assigned to group of 47 patients receive either received anise powders, 3 g after each meal (3 times/day) or placebo involved 60 patients and received placebo powders (corn starch), 3 g after each meal (3 times/day) for 4 weeks.  researcher found that anise group expressed a significant effect in reduced all symptoms at weeks 4 and 12, but retching, nausea and vomiting in compared to control group and at the baseline.

The examine of the mean total scores of FD severity scale in anise group also expressed improvement at weeks 2, 4 and 12 in compared to insignificantly different of the two groups before the intervention.

Anise intervention also demonstrated a decreased significantly of mean severity scores of epigastric fullness, epigastric discomfort, epigastric burning/pain, early satiety, bloating, belching, and loss of appetite in compared to epigastric pain, epigastric fullness and belching increased significantly in the placebo group after intervention.

Moreover, Anise group also exerted a strong improvement of  mean of pain score in compared to placebo, probably as a result of its anti spasmolytic feature.

However, after taking into account of other co founders such as factors in causes of FD and  anise effects on broad spectrum of pharmacological effects on GI, nervous, muscular and immune systems, researchers concluded that there are no surprise that Anise application showed a significant improvement of symptoms in patients with FD.

The information findings may be astonished, but the study also found to induce certain limitation, including limited the external validity of the results with a small sample size and shorted follow up periods.

Taking together, herbal Anise not only improve quality of life in patients with  functional dyspepsia but may also be considered as adjunct therapy in combined with conventional standard medicine for reduced symptoms and treatment of functional dyspepsia. 

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Pimpinella anisum in modifying the quality of life in patients with functionaldyspepsia: A double-blind randomized clinical trial by Ghoshegir SA1, Mazaheri M2, Ghannadi A3, Feizi A4, Babaeian M5, Tanhaee M3, Karimi M6, Adibi P7.(PubMed)(PMC)
(2) Pimpinella anisum in the treatment of functional dyspepsia: A double-blind, randomized clinical trial by Ghoshegir SA1, Mazaheri M2, Ghannadi A3, Feizi A4, Babaeian M5, Tanhaee M3, Karimi M6, Adibi P7.(PMC)