Food therapy: Dietary Carrot In Attenuated Onset and Treatment of Prostate Cancer

Kyle J. Norton

Carrots may have a profound and positive effect in reduced risk, progression and treatment of prostate cancer, some scientists suggested.

Prostate cancer is a condition characterized by cell growth disorderly and uncontrollably in prostate tissue. At the later stage, the cancerous cells may infect other healthy tissue and organ a distance away from the original site.

Carrot, a root vegetable with orange color is a sub spices of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

Nutritional Benefits 
1. Carbohydrates
2. Sugars
3. Fibre
4. Fat
5. Protein
6. Vitamin A
7. Thiamine (VittaminB1)
8. Riboflavin (Vittamin B2)
9. Niacin (Vittamin B3)
10. Vitamin B6
11. Folate (Vittamin B9)
12. Vitamin C

13. Vitamin K
14. Calcium
15. Iron
16. Magnesium
17. Molybdenum
18. Phosphorus
19. Potassium
20. Sodium


In the study to verify the effect of carrots in risk of prostate cancer by reviewing publication of literature in August 2013 of PubMed, EMBASE, Scopus, Web of Science, the Cochrane register, and the Chinese National Knowledge Infrastructure databases, and the references of the retrieved articles, researchers at the Zhejiang University found that intake of carrot demonstrated a significantly reduced risk of prostate cancer with the odd ratio of .82 in compared to non serving group.

Risk of prostate cancer was decreased by 5% and 6% in intake of a weekly portion of 10 g of carrot increment without precipitating adverse effect.

Dr. Xu X, the lead author suggested that intake of carrot frequently with limit volume may have a profound effect in reduced prostate cancer risk.

Further analysis of the potential effect of lycopene extract found abundantly in tomato and carrot in decreased risk of onset and treatment of prostate cancer indicated that lycopene inhibited prostate cancer proliferation through modulated the expression of PI3K/Akt pathway prostate cancer cell lines  in regulating cancerous cellular functions including metabolism, growth, proliferation.

Dysfunction of the PI3K/Akt pathway was associated to a number of human diseases including cancer, diabetes, cardiovascular disease and neurological diseases.

Moreover, application of lycopene also displayed a strong effect in inhibited the proliferation of androgen-dependent prostateLNCaP cancer cells through the activation of the peroxisome proliferator-activated receptor gamma (PPARγ) with function to act as a tumor suppressor in prostate cells due to it activity in induction of  agonist ligands in inhibited growth of prostate cancer cells.

Additionally, the phytochemical also expressed a significant activity in exhibited the liver X receptor alpha (LXRα) in reduce proliferation of human oral cancer cells by promoting cell cycle arrest through increased expression of the cyclindependent kinase inhibitor p27, a tumor suppressor and promoted function of extracellular ATP-binding cassette transporter 1 (ABCA1) pathway in inhibited tumor growth through modulation of macrophage function within the tumor, and in established a link between cholesterol homeostasis and cancer.

Application of lycopene (10 μM) in the presence of a specific antagonist of PPARγ (GW9662) or LXRα (GGPP) exerted a huge effect in reduced liver X receptor α knockdown in induction of resistance against LXRα  in promoted the proliferation of DU145 cells.

Interestingly, lycopene in combination with the LXRα agonist T0901317, a potent chemical compound used in assays, exhibited anti prostate cell proliferative activity through interaction with protein expression of PPARγ, LXRα and ABCA1 in initiated cancer cell apoptosis.

In conclusion, Dr. Yang CM, the lead authors said, "These results demonstrate that lycopene can inhibit DU145 cell proliferation via PPARγ-LXRα-ABCA1 pathway and that lycopene and T0901317 exhibit synergistic effects".

The result findings strongly suggested that long term intake of carrot in moderate amounts may have substantial implication in prevention and treatment of prostate cancer. But Intake of carrot supplement should be taken with care to prevent acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Dietary carrot consumption and the risk of prostate cancer by Xu X1, Cheng Y, Li S, Zhu Y, Xu X, Zheng X, Mao Q, Xie L(PubMed)
(2) The effect of lycopene on the PI3K/Akt signalling pathway in prostate cancer by Chen J, O'Donoghue A, Deng YF, Zhang B, Kent F, O'Hare T(PubMed)
(3) Lycopene and the LXRα agonist T0901317 synergistically inhibit the proliferation of androgen-independent prostate cancer cells via the PPARγ-LXRα-ABCA1 pathway by Yang CM1, Lu YL, Chen HY, Hu ML(PubMed)