Herbal Therapy: Herbal Catnip in Ameliorated Risk and Treatment of Lung Cancer

Kyle J. Norton 

Catnip may have a potential and substantial effect in reduced risk and treatment of lung cancer, some scientists suggested.

Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia,  use in herbal medicine as insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritations stimulate sweating, promote menstruation, etc..

Ingredients
Terpenoid nepetalactone, α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc..

Lung cancer is medical condition characterized by irregular cell growth in the issues of lung. At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.

According to statistic, In 2015, approximately 26,600 Canadians will be diagnosed with lung cancer and 20,900 will die of it.

According to the investigation of the anti cancer effect of extracts isolated from catnip containing sub-fractions (ND-1-ND-15) of ND using human lung cancer cells (A-549) experiment, the selected sub-fractions of the chloroform extract demonstrated a significantly activity in reduced the cell viability of A-549 cells, through alternated the cancer cell structures and arrangement in a concentration-dependent manner.

In classification of the effect of each individual sub fraction researchers found that ND-10 fraction induces the greatest cytotoxicity in lowest dose in compared to other fractions with ND-1 does not cause any cytotoxicity even at higher concentrations.

In compared to other cancer cell lines, human lung cancer cells (A-549) was found to be more sensitive to the application of the extracts.

Further differentiation of the Nepeta cataria L. anti-cancer treatment effect recorded in the Chinese Pharmacopoeia of version 2015 and belongs to one of the Traditional Chinese medicine (TCM). Microfluidic chip technology, researchers at the joint study lead by the Liaoning University of Traditional Chinese Medicine conducted a study based on total flavonoid extracted from Nepeta cataria L. (TFS) on risk of human lung cancer cell line A549 using the microfluidic device and Flow Cytometry assays, suggested that the bioactive chemicals exert a significant activity in inhibited cancer cell proliferation and tumor progession and invasion through mRNA expression of MicroRNA-126 (miR-126) which plays an important role involved in post-transcriptional regulation of gene expression in inhibition of human cancer progression, regulating apoptosis of cancer cells.

Additionally, the anti lung cancer expression was attributed to ameliorate the vascular endothelial growth factor (VEGF), a potent angiogenic factor with function to trigger development of new blood vessel to supply nutrients and oxygen to ignite cancer cell proliferation and inhibited the expression of the PI3K signalling pathway which is correlated to the cancer aggression and invasive malignancy.

 Researchers also indicated that according to the Flow Cytometry assay, the phytochemicals also exhibit the expression of PTEN (phosphatase and tensin homologue deleted on chromosome 10) PTEN gene in initiated tumor suppressible activity through expression PI3K-AKT pathway in induced cell cycle arrest or apoptosis in human cancer cells

Dr. Jiaxin Fan, the lead author, after taking into account of other confounders said, " Taking all these results into consideration we can draw a conclusion that TFS may be used as a novel therapeutic agent for NSCLC in the near future".

The information findings postulated that herbal catnip with abundant bioactive compounds may be considered as a function food in reduced risk and treatment of human lung cancer, depending to further differentiation.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Anticancer Activity of Chloroform Extract and Sub-fractions of Nepeta deflersiana on Human Breast and Lung Cancer Cells: An In vitro Cytotoxicity Assessment by Al-Oqail MM1, Al-Sheddi ES1, Siddiqui MA2, Musarrat J2, Al-Khedhairy AA2, Farshori NN1.(PubMed)
(2) Mechanism of modulation through PI3K-AKT pathway about Nepeta cataria L.’s extract in non-small cell lung cancer by Jiaxin Fan,#1 Yongrui Bao,#1,2,3,4 Xiansheng Meng,1,2,3,4 Shuai Wang,1,2,3,4 Tianjiao Li,1,2,3,4 Xin Chang,1 Guanlin Yang,1 and Tao Bo4(PMC)