Herbal Therapy: Herbal Catnip In Blocking Entry Phase of Prostate Cancer Onset

Kyle J. Norton 

Catnip may have a potential and substantial effect in reduced risk of pre-malignant cells slowly change from the properties of normal cells to cancer-like properties in initiated prostate cancer, some scientists suggested.

Catnip is also known as catswort, or catmint, a plant of Nepeta, belonging to the family of Lamiaceae, native to Europe and Asia, used in herbal medicine as insect repellant and to treat digestive disorders, children restlessness and nervousness, fevers, cold and flu, skin irritations stimulate sweating, promote menstruation, etc..

Ingredients
Beside the major constituent of terpenoid nepetalactone, the herb also contains α-Pinene, β-Pinene, Cyclohexen-1-yl-methyl ketone, Triplal, Thymol, Nepetalactone, Nepetalactone, etc..

Prostate cancer is medical condition characterized by irregular cell growth in the issues of prostate.  At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away from the original site.

According to statistic, based on 2012-2014 data, approximately 11.6 percent of men will be diagnosed with prostate cancer at some points during their lifetime.

On PC3 and DU145 prostate cell lines, in comparison of the effective of methanol extracts, n-hexan, methylene chloride (CH2Cl2), ethyl acetate (EtOAc), n-butanol (n-BuOH), and H2O fractions and the essential oil isolated from the aerial parts of the catnip to examine the cytotoxic and apoptogenic activity found that application of ethyl acetate extract in compared to other extracts, displays a strong inhibited property in decreased prostate cancer cell viability in PC3 cell line, through cell cycle arrest in the sub-G1 area, where the cancer cell has lost some DNA structure, in a concentration dependent manner.

Furthermore, through observation of IC 50 values, ethyl acetate (EtOAc) expressed a greater significant activity in estrogen receptor positive PC3 cells which are more sensitive to the cytotoxic effects in comparison with low hormone-receptor presenting DU-145 cells.

Interestingly, ethyl acetate (EtOAc) in inhibited PC3 cancer cell line with lesser value of IC50 and greater effect than other tested compounds was attributed to the activity of  PC3 cells can change its negative androgen receptors profile to positive (PC3AR+)

The study also indicated that more cytotoxic activity of N. cataria found on PC3 cells in comparison with DU145 AR¯ cells might also due  to different response of cells to sex hormones.

Additionally, according to the Western blotting analysis administration of ethyl acetate extract after 48 hours securely induced cancer apoptosis through activated caspase 3 cleavage which has been found to be an important marker and in associated to the cell’s entry point into the apoptotic signaling pathway and Poly(ADP-ribose) polymerase (PARP) which also plays an essential role in execution of the apoptotic event and an early indicator of apoptosis.

Moreover, researchers also found that the Catnip extract also increased level of Bax Protein after 48 hours of exposure in initiated cancer cell apoptosis with release of cytochrome c, an early phase of cell degradation and death.

After taking into account of other con founders, Dr. Emami SA, the lead author said, " the semi polar EtOAc extract of N. cataria induces apoptosis in pc3 cells compare to DU-145 cells and further analytical assays are suggested to identify the active phytochemicals possess cytotoxic activity".

Taking altogether, eggplant with plenty phytochemicals may be considered as a functional food in reduced risk of Prostate cancer through blocking the entry phase of  the onset of prostate cancer.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Growth Inhibition and Apoptosis Induction of Essential Oils and Extracts of Nepeta cataria L. on Human Prostatic and Breast Cancer Cell Lines by Emami SA1, Asili J, Hossein Nia S, Yazdian-Robati R, Sahranavard M, Tayarani-Najaran Z. DOI:http://dx.doi.org/10.7314/APJCP.2016.17.S3.125