Herbal Therapy: Green Tea and Its Bioactive Epigallocatechin-3-gallate (EGCG) in Ameliorated Risk and Treatment of Ischemic Related Diseases

Kyle J. Norton 

Green tea may have a substantial and profound effect in reduced risk of  ischemic related diseases, some scientists postulated.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Ischemic related diseases are the class of disease caused over expression of free raicals in induction of lipid peroxidation including atherosclerosis, ischemia-reperfusion, heart failure, Alzheimer's disease, rheumatic arthritis, cancer, and other immunological disorders.

The investigation of green tea effect and risk ischemic related diseases in a total of 9 studies selected from medical literature published through October 2014, satisfied the criteria and guideline, including 259,267 individuals showed that people who do not consume green tea express a higher risks of CVD of 1.19, intracerebral hemorrhage of 1.24, and cerebral infarction of 1.15 in compared to those drinking <1 cup green tea per day.

For those who drank 1-3 cups of green tea per day,   risk of myocardial infarction and stroke are reduced to risk ratio of 0.81 and 0.64, respectively, in compared to those who drank <1 cup/day.

Not surprisingly, those who drank ≥4 cups/day had a reduced risk ratio of 0.68 of myocardial infarction in compared to those who drank <1 cup/day.

And finally, people consumed ≥10 cups/day of green tea were also found to lower LDL with risk ratio of 0.90 in compared to the <3 cups/day group.

The finding evidences of meta study indicated a strong implication of green tea intake linearly associated to reduce risk ischemic related diseases.

People who are at higher risk of ischemic related diseases may want to add a cup or 2 of green tea as beverage in their diet for preventive measure.

Further illustration of the effect of green tea in reduced risk of ischemic related diseases researchers at the Second Affiliated Hospital of ZhengZhou University conducted a study to investigate the EGCG activity in the acute phase of ischemic stroke, indicated that pretreatment of EGCG displays a significant effect in reduced risk ischemic stroke via nuclear factor erythroid 2-related factor 2 (Nfr2) signaling pathway, the expression of antioxidant proteins that protect against oxidative damage triggered by ROS in induction of injury and inflammation.

In rat model of transient middle cerebral artery occlusion, EGCG treatment demonstrated a significant effect in expression of neurologic outcome, with less infarct volume, more number of Ki67/CD31-positive vessels, higher expression of the number of microvessels in tissue, thus increasing blood flow in the brain in compared to mice group treated only with MCAO.

Further more, application of green tea also exeted a significant antioxidant effect in inhibited the over production of ROS in induction of chain reactive through activated Nrf2 expression, thus decreasing oxidative stress in compared to MCAO+vehicle-treated mice.

Interestingly, EGCG also up regulated the VEGF-VEGFR2 signaling pathway which plays important roles in the development and function of the circulatory and nervous systems, involved providing nutrients and oxygen and induced protective effects on brain neurons.

After taking into account of other con founders, Dr. the lead researcher concluded, "EGCG treatment in the early stage of ischemic stroke can promote angiogenesis in MCAO mice, possibly via upregulation of Nrf2 signaling pathway".

Taken together, green tea with abundant bioactive polyphenols such as Epigallocatechin-3-gallate (EGCG) may be considered as a functional food in reduced risk and treatment of ischemic related diseases, particularly in high risk population. Intake of green tea extract should be taken exceptional care as over dose can induce acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Epigallocatechin-3-gallate promotes angiogenesis via up-regulation of Nfr2 signaling pathway in a mouse model of ischemic stroke by Bai Q1, Lyu Z2, Yang X1, Pan Z3, Lou J4, Dong T5.(PubMed)
(2) Green tea consumption and risk of cardiovascular and ischemic related diseases: A meta-analysis by Pang J1, Zhang Z2, Zheng TZ3, Bassig BA4, Mao C5, Liu X5, Zhu Y4, Shi K6, Ge J7, Yang YJ8, Dejia-Huang5, Bai M9, Peng Y9.(PubMed)