Food Therapy: Coffee, the Functional Food In Attenuated Risk and Treatment of Liver Cancer

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Good news to all coffee drinkers regularly, Coffee and coffee caffeine intake may have a profound effect in reduced risk, delay progression and treatment of liver cancer, according to the suggestion by the joint study led by German Institute of Human Nutrition Potsdam-Rehbrücke.

Liver cancer is a medical condition characterized by cell growth disorderly and unmanageable in the liver organ. The disease at the later stage may travel a distant away to other tissues or organs.

Coffee, becoming a popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.


In a prospective nested case-control study within the European Prospective Investigation into Cancer and Nutrition among 125 incident HCC cases matched to 250 controls using an incidence-density sampling procedure, scientists found that the relative risk ratio in coffee group was lower significantly for patients drinking ≥4 cups (600 mL) in compared to compared those with less than 2 cups per day.

After additional evaluation, researchers indicated that the efficacy of coffee in ameliorated risk of liver cancer incidence may attribute to biochemicals in inhibited the proinflammatory and exhibited antioxidant expressions.

The combined functions in decreased  proinflammatory expression and improved antioxidant status also showed a greater activity in reduced the regression coefficients by 0.72. These results confirmed the inverse association of coffee intake with HCC risk probably due to biomarkers of inflammation and and free radical production in hepatocellular injury.

Other, in the newly diagnosed case patients (250 men and 84 women) with HCC identified from a 10-year follow-up of the Japan Public Health Center-based Prospective Study consisting 90,452 middle-aged and elderly Japanese subjects (43,109 men and 47,343 women), after taking into account of other confounders, researchers filed the following results
1. People drinking coffee daily and regular had a lower HCC risk in compared to those almost never drank coffee.
2.The risk of liver cancer decrease linearly to numbers of cup of coffee consumed.
3. Explicitly, The risk of liver cancer in almost never drinkers was 547.2/100,000 people over 10 years, in compared to 214.6/00 000 people, drinking coffee on a daily basis.

More importantly, in the hepatitis B and C positive groups of this population, coffee drinking daily showed a similar effect to those without.

In further support the above differentiation, the Saga University filed a case-control study of recruited 209 incident HCC cases and three different controls (1308 community controls, 275 hospital controls, and 381 patients with chronic liver disease [CLD] without HCC), all of whom were aged 40-79 years and residents of Saga Prefecture, Japan, suggested that coffee intake during showed a linearly negative effect in risk of cancer, depending to cups coffee consumed daily in long term drinkers.

Taking altogether, there is no doubt that coffee intake has a significant and positive effect in reduced risk and treatment of liver cancer regardless to viral expression such as hepatitis B, C......

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Sources
(1) The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: data from the European Prospective Investigation into Cancer and Nutrition by Aleksandrova K1, Bamia C2, Drogan D3, Lagiou P4, Trichopoulou A2, Jenab M5, Fedirko V6, Romieu I5, Bueno-de-Mesquita HB7, Pischon T8, Tsilidis K9, Overvad K10, Tjønneland A11, Bouton-Ruault MC12, Dossus L12, Racine A12, Kaaks R13, Kühn T13, Tsironis C14, Papatesta EM14, Saitakis G14, Palli D15, Panico S16, Grioni S17, Tumino R18, Vineis P19, Peeters PH20, Weiderpass E21, Lukic M22, Braaten T22, Quirós JR23, Luján-Barroso L24, Sánchez MJ25, Chilarque MD26, Ardanas E27, Dorronsoro M28, Nilsson LM29, Sund M30, Wallström P31, Ohlsson B32, Bradbury KE33, Khaw KT34, Wareham N35, Stepien M5, Duarte-Salles T5, Assi N5, Murphy N36, Gunter MJ36, Riboli E36, Boeing H3, Trichopoulos D37.(PubMed)
(2) Influence of coffee drinking on subsequent risk of hepatocellular carcinoma: a prospective study in Japan by Inoue M1, Yoshimi I, Sobue T, Tsugane S; JPHC Study Group.(PubMed)