Food Therapy: Coffee and Caffeine Intake in Attenuated Risk of Hepatic Fibrosis

By Kyle J. Norton



Intake of coffee daily and regularly may be considered as a functional beverage in reduced risk and treatment of  liver fibrosis, a renowned institute study suggested.

Hepatic fibrosis is a condition characterized by overly exuberant wound healing causing excessive connective tissue builds up in the liver.

Coffee, the best popular and social beverage all over the world, particularly in the West, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.

In the examine 910 patients with chronic HCV infection, 98% male and 38% with advanced hepatic fibrosis, researchers filed the following results
1. Intake of coffee is lower in control group in compared with advanced fibrosis
2. But caffeine intake of higher than 100 mg or more, daily from all sources was found in controls (66.0%) than patients with advanced fibrosis (57.9%)
3. Caffeine intake of controls mostly come from coffee intake
4. Intake of average daily intake of 100 mg or more of caffeine (adjusted odds ratio, 0.71; 95% confidence interval, 0.53-0.95; P = .020) was associated in increased liver protective effect.

The result demonstrated that moderately coffee and coffee caffeine intake of 100 mg may have a protective benefit against risk of advanced hepatic fibrosis.

Additionally, in the study, using food-frequency instrument for dietary caffeine consumption to evaluate the relationship between caffeine intake and liver fibrosis in patients undergoing liver biopsy completed a detailed caffeine questionnaire on three occasions over a 6-month period, researchers at the National Institutes of Health (NIH), reported the results as follow
1. Daily caffeine consumption of 308 mg = approximately 2.25 cups of coffee equivalents was associated with reduced liver fibrosis
2. The protective association persisted without changing even after taking into account of other factors,
3. In compared to coffee caffeine, other sources of caffeine showed insignificant effect in decreased risk liver fibrosis.

After making adjustment from all sources, Dr. Modi AA, the lead author said, " . A reliable tool for measurement of caffeine consumption demonstrated that caffeine consumption, particularly from regular coffee, above a threshold of approximately 2 coffee-cup equivalents per day, was associated with less severe hepatic fibrosis."

Promisingly, in the study of chronic HBV-infected patients underwent transient elastography examination in 2006-2008, questionnaire returned from among 1045 patients, 216 (20.7%) patients with advanced fibrosis., researchers also found the similar results in compared to other studies as follow
1. The percentage of patients who drank ≥ 1 cup of coffee had advanced fibrosis was 95 (19.0%) , compared with 1.21 (22.2%) patients who drank < 1 cup (P = 0.21).
2. Caffeine intake does not affect liver stiffness in chronic HBV-infected patients in compared to coffee intake

Taking together, there is no doubt that coffee intake may have a profound effect in ameliorated risk of hepatic fibrosis and advanced hepatic fibrosis regardless amount intake daily.

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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee and Caffeine Are Associated With Decreased Risk of Advanced Hepatic Fibrosis Among Patients With Hepatitis C by Khalaf N1, White D1, Kanwal F1, Ramsey D1, Mittal S1, Tavakoli-Tabasi S2, Kuzniarek J3, El-Serag HB4.(PubMed)
(2) Increased caffeine consumption is associated with reduced hepatic fibrosis by Modi AA1, Feld JJ, Park Y, Kleiner DE, Everhart JE, Liang TJ, Hoofnagle JH.(PubMed)
(3) The effect of caffeine and alcohol consumption on liver fibrosis - a study of 1045 Asian hepatitis B patients using transient elastography by Ong A1, Wong VW, Wong GL, Chan HL.(PubMed)