Herbal Therapy: Chaste tree berry, The Best Antinociceptive Functional Food

Kyle J. Norton



Whole food ingredients in herbal plant have been found to process some significant effects in reduced risk and treatment of certain diseases, but single ingredient isolated from such plants may induce opposite outcomes.

A recent study suggested that essential oil isolated from Chaste tree berry mayhave a potential effect in reduced neuro-pain through antinociceptive function in tested subjects.
Antinociceptive effect is the activity in reduced pain through interference with information transmitted and received of brain neurons.

Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.

In the study of three behavioral models of nociception in adult male Wistar rats conducted by the University of Tabriz, topical essential oil extracted from Vitexagnus-castus (EOVAC) applied on  animal expressed a reduced pain responses in tail immersion tests, inhibited the acetic acid-induced writhing response with little adverse effects.

Dr. Khalilzadeh E, the lead author said, " major components of the EOVAC were α-pinene (14.83%), limonene (10.29%), β-caryophyllene (6.9%), sabinene (5.27%), and β-farnesene (5.9%), (may have direct infleunce to the) endogenous opioidergic system as well as muscarinergic receptors of cholinergic system may be involve in the antinociceptive activity of Vitex agnus-castus essential oil in these models of pain in rats".

Interestingly, the extract of herbal medicine also displayed a strong effect against chronic inflammation in induced pain.

The joint study lead by the Federal University of Santa Maria suggested that crude extract caused antinociceptive/antidepressant-like effects in the CFA-induced chronic inflammation model in comparable to naloxone, without altered inflammatory parametersat doses of 10mg/kg,

This result indicated that The VmE extract demonstrated pain relief through inducing opioid-dependent antinociception and antidepressant-like effects, without anti-inflammatory activity.

Further more, in the investigated petroleum ether fraction (PEF) from the aqueous ethanol extract of Chaste tree berry in several nociceptive mouse models, mouses treated with the fraction produced significant dose-related inhibitions on chemical nociception in comparable to Naloxone (1 mg/kg bw subcutaneously), a non-selected opioid receptor antagonist.

In xylene-induced ear edema test, the fraction also exerted a strong analgesic effects partially mediated by its anti-inflammatory activity.

Taking together, Chaste tree berry may have a therapeutic potential to be used as antinociceptive functional food in reduced pain through blocking the information transfer by neurotransmitters.

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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Antinociceptive effects, acute toxicity and chemical composition of Vitex agnus-castus essential oil by Khalilzadeh E, Vafaei Saiah G, Hasannejad H, Ghaderi A, Ghaderi S, Hamidian G, Mahmoudi R, Eshgi D, Zangisheh M.(PubMed)
(2) Antinociceptive and antidepressant-like effects of the crude extract of Vitexmegapotamica in rats by Hamann FR1, Zago AM2, Rossato MF3, Beck VR4, Mello CF4, de Brum TF5, de Carvalho LM6, Faccin H6, Oliveira SM7, Rubin MA8(PubMed)
(3) Antinociceptive activities of the liposoluble fraction from Vitex negundo seeds by Zheng CJ1, Huang BK, Han T, Zhang QY, Zhang H, Rahman K, Qin LP.(PubMed)