Food Therapy: Coffee Caffeine In Risk of Ovarian Cancer Incidence?

By Kyle J. Norton

Bad news for postmenopausal women coffee lovers, caffeinated coffee may have a positive effect in exhibited risk for epithelial ovarian cancer, a study by a respectable institute proposed.

Coffee, a popular and social beverage all over the world, particular in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Epithelial ovarian tumor also known as Surface epithelial-stromal tumor, is a result of irregular cells growth on the surface of the ovary. Epithelial ovarian tumor is the most common form of ovarian cancer accounted for over 90% of ovarian cancer of all cases.

According to the University of Minnesota, coffee consumption of more than five cups a day may be associated with increased risk of ovarian cancer in postmenopausal women.

In the evaluated the risk of coffee and caffeine intake against epithelial ovarian cancer in a prospective cohort study of 29,060 postmenopausal women, returned questionnaire from ovarian cancer patients from 1986 to 2004. suggested that increased risk of epithelial ovarian cancer incidence was found in women who consumed more than 5 cups per days.in compared to the lesser cup drinkers and non drinkers.

The study also indicated that decaffeinated coffee and caffeine showed no statistically significantly associated with ovarian cancer incidence.

Other, in the evaluated enzyme CYP1A2 in the metabolism of coffee from the data collected from a preliminary investigation conducted in Hawaii of 164 epithelial ovarian cancer cases and 194 controls, women with CYP1A2 genotype modifies, the results showed that coffee consumption in these population expressed a substantially increased risk of ovarian cancer in compared to women who did not drink regular coffee.

Furthermore, Women with any CYP1A2 C allele and women with the A/A genotype were associated to similar risk of ovarian cancer (OR = 1.1, 95% CI = 0.7-1.7) but the increased risk of ovarian cancer was stronger among women with the A/A genotype than among women with any C allele.

Dr. Goodman MT, the lead author said., "preliminary data suggest a modest positive association of caffeine and coffeeconsumption with the OR for ovarian cancer that may be modified by CYP1A2 genotype and exposures, such as cruciferous vegetable consumption, that influence CYP1A2 expression".

However, according to the Information on coffee consumption collected from 91,767 women at baseline in the Norwegian Women and Cancer Study, coffee intake was found to reduced risk of various types of cancer, including ovarian caner, with no statistic different in women who drank more than 3 and up to 7 cups/day, and women who drank ≤1 cup/day.

Taking together, intake of coffee regularly with less than 5 cups per day may be associated to ameliorated risk of ovarian cancer incidence, but women with  enzyme CYP1A2  modified and  C allele and post menopause women should consult with their doctor before applying.

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Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee and caffeine intake and the risk of ovarian cancer: the Iowa Women's Health Study by Lueth NA1, Anderson KE, Harnack LJ, Fulkerson JA, Robien K.(PubMed)
(2) Coffee and caffeine intake and the risk of ovarian cancer: the Iowa Women's Health Study by Lueth NA1, Anderson KE, Harnack LJ, Fulkerson JA, Robien K.(PubMed)
(3) Coffee consumption and the risk of cancer in the Norwegian Women and Cancer (NOWAC) Study by Lukic M1, Licaj I2, Lund E2, Skeie G2, Weiderpass E2,3,4,5, Braaten T2.(PubMed)