Hormone Therapy: Progesterone in Reduced Risk of Pre Term Birth

By Kyle J. Norton

Women with history of pre mature birth may be benefits from injection of hormone progesterone to reverse the incidence of recurrence, a renowned institute study suggested,

Progesterone is a steroid hormone, produced by the women body to regulate part of the menstrual cycle and supporting the gestation and the process of sperm in egg fertilization.

Preterm birth is a term for any infant born less than 37 weeks gestational age.

According to the joint study lead by the Universitätsklinikum Heidelberg, progesterone has a profound effect in protect the cervix in strengthen the layers of the uterine wall, reduced the myometrial contractility and inhibited the production of pro inflammatory cytokins.

In the review of literature of database from PubMed published from 1956 to August 2014, women with previous preterm birth incidience received vaginal progesterone daily (200 mg capsule or 90 mg containing gel) at from 16+0 to 36+0 weeksm showed a significant improvement in reduced risk of preterm incidence and infant mortality.

The same term of progesterone injected to women with short cervix also benefits in attenuated risk of preterm birth <28, <33, and <35 weeks of gestation.

Unfortunately, progesterone therapy showed inconclusive evidences as maintenance therapy after arrest of preterm labor.

Dr. Kuon RJ, the lead author said, " The vaginal administration of progesterone is well-tolerated by the patients and has only minor maternal side effects".

Other researchers in the finding of pre term incidience suggested that a short cervix may be a clinically silent sonographic in the midtrimester in induced pre term accident. Injection of  vaginal progesterone showed a huge improvement in reduced rate of preterm delivery by 45% as well as the rate of neonatal morbidity.

According to the study, the hormone therapy substantially decrease rate of spontaneous preterm birth with a short cervix in both women with and without a prior history of preterm birth in compared to conventional medicine 17α-Hydroxyprogesterone caproate.

In support to the above analysis, a reviewed analysis of 36 randomised controlled trials (8523 women and 12,515 infants) indicated that progesterone treatment for women with a past history of spontaneous preterm birth showed a statistically significant reduction in the risk of perinatal mortality in compared to placebo, particular in the risk of preterm birth less than 34 weeks' gestation.

In compared to placebo, the study also found that progesterone therapy addressed a significant reduction in the risk of infant birthweight less than 2500 g in other risk factors not related to history and short cervix.

Taking altogether, application of hormone progesterone showed a increadible result in reduced risk of preterm birth between 28  - 34 weeks of gestation in both women with or without previous history of preterm  incidence.

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Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Source

(1) [Progesterone for Prevention of Preterm Birth--Evidence-based Indications]. [Article in German] by Kuon RJ1, Abele H2, Berger R3, Garnier Y4, Maul H5, Schleußner E6, Rath W7; Experts for the Prediction and Prevention of Preterm Birth (X4PB) – www.x4pb.de.(PubMed)
(2) Progesterone to prevent spontaneous preterm birth by Romero R1, Yeo L2, Chaemsaithong P2, Chaiworapongsa T2, Hassan SS2.(PubMed)
(3) Prenatal administration of progesterone for preventing preterm birth in women considered to be at risk of preterm birth by Dodd JM1, Jones L, Flenady V, Cincotta R, Crowther CA.(PubMed)