Food Therapy: High Coffee Intake During Pregnancy, A Potential Risk Of Infant's Acute Lymphoblastic Leukemia (ALL)

By Kyle J. Norton


In compared to herbal medicine, food therapy even takes longer to ease symptoms, depending to stage of the treatment which directly addresses to the cause of disease.

Women, drinking moderated coffee during pregnancy may have a profound effect in increased risk of infants' acute lymphoblastic leukemia (ALL), a renowned institute suggested.

Coffee, the popular and social beverage all over the world, after green tea, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Acute leukemia is condition of rapid increase in the numbers of extreme immature white blood cells in the blood stream,  tissues and organs.

According to the 12 case-control studies, comprising a total of 3649 cases and 5705 controls, coffee and coffee caffeine consumption were associated linearly to higher risk of childhood leukemia, by the dose-response analyses.

Dr. Thomopoulos TP, the lead researchers said, " detrimental association between maternal coffee consumption and childhood leukemia risk and provide indications for a similar role of maternal cola intake".

Instantly, in the review of literature data base of up to May 5, 2013, and the lists of references of retrieved articles in screened to identify additional relevant studies, researchers filed the following results
1. In low to moderate-level drinkers during pregnancy, risk of children Acute Lymphoblastic Leukemia (ALL)  was 1.22
2. A maternal coffee highest consumption was statistically significantly associated with childhood ALL of 1.65 in compared to non drinker.

Dr. Cheng J, the lead author said, "maternal coffee consumption during pregnancy may increase the risk of childhood AL" and " linear dose-response relationship of coffee consumption and childhood AL (P for nonlinearity = .68), including childhood ALL and childhood AML; with increased coffee consumption, the risk of childhood AL increased".

Furthermore, in the reviewed French ESCALE study, included 764 AL cases and 1,681 controls in 2003-2004 in women with Genotypes of the candidate alleles (NAT2*5 rs1801280, ADH1C*2 rs698 and rs1693482, CYP2E1*5 rs2031920 and rs3813867), regular coffee drinking expected mother was associated with childhood AL and the incidence increased linearly with daily intake (p for trend <0.001; >2 cups per day vs. no or less than 1 cup per week).

There was no association between gene alternation and risk of children ALL found among these women.

The findings suggested that maternal coffee consumption during pregnancy may increase risk of childhood AL. Women who have a previous history of this type of incidence should reduce intake of coffee in preventive measure.

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Author biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Maternal and childhood consumption of coffee, tea and cola beverages in association with childhood leukemia: a meta-analysis by Thomopoulos TP1, Ntouvelis E1, Diamantaras AA2, Tzanoudaki M3, Baka M4, Hatzipantelis E5, Kourti M6, Polychronopoulou S7, Sidi V6, Stiakaki E8, Moschovi M9, Kantzanou M1, Petridou ET10.(PubMed)
(2) Maternal coffee consumption during pregnancy and risk of childhood acute leukemia: a metaanalysis by Cheng J1, Su H2, Zhu R3, Wang X1, Peng M1, Song J1, Fan D1.(PubMed)