Herbal Therapy: Andrographis, The Natural Herbal Medicine for Protection of Cigarette Smoke Induced Lung Disease

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

In Herbal Medicine, symptoms of the diseases can only be eased gradually, depending to stage of the treatment which directly address to the cause.

Andrographis paniculata may protect our body against cigarette smoke-induced inflammation cause of lung disease, a renowned study postulated.

Andrographis paniculata, also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka, used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, ......

Cigarette contains harmful chemicals including acetone, acetic acid, ammonia, arsenic, benzene butane, etc......which have been proven to induced varies respiratory diseases, including lung disease.

According to the The First Affiliated Hospital of Zhengzhou University, in CS-exposed mice, andrographolide, a chemical constituent found in Andrographis, significantly attenuated lung inflammation through reduced numbers of total cells of neutrophils, a common type of white blood cells, and macrophages, a cell found in stationary form in the tissues of infection in bronchial alveolar lavage fluid (BALF) of intestinal lung disease, together with decreased production of cytokine/chemokine(small cytokine), pro-inflammatory meediators into BALF.

Dr. Yang D., the lead author in the study said, " Andrographolide, a bioactive molecule isolated from Andrographispaniculata, could protect against cigarette smoke (CS)-induced lung injury through activation of heme oxygenase-1 (HO-1), (an enzyme with function in response stress)".

The study also insisted that the effects of andrographis in ameliorated cigarette smoke-induced lung disease, probably involved the activation of protein in mediated cellular responses STAT3, together with enzyme HO-1.

In female BALB/c mice exposed to 2 weeks of cigarette smoke(CS0 followed by a single intratracheal instillation of NTHi, a respiratory tract pathogen common in local infection study, andrographolide promoted gene expression of antioxidant enzymes such as heme oxygenase-1 (HO-1), glutathione reductase (GR), glutathione peroxidase-2 (GPx-2), glutamate-cysteine ligase modifier (GCLM), and NAD(P)H quinone oxidoreductase 1 (NQO1), against lung inflammation caused by NTHi in cigarette smoke.

Furthermore, in cigarette smoke-induced oxidative lung injury, andrographolide activated nuclear factor erythroid-2-related factor 2 (Nrf2), a protein in regulated expression of antioxidant proteins against oxidative damage.

The study also suggested, the phytochemical also suppressed cigarette smoke-induced increases in lavage fluid cell counts, pro inflammatory cutokines and oxidative stress, through enhancing production of antioxidant properties against biomarkers in inducing lung diseases.

The information collected through studies strongly support a therapeutic potential for andrographolide in preventing lung diseases caused by harmful chemicals and pathogens in cigarette smoke.

Arthritis Is Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic 
Impact In Rice, Pasta, And Potatoes In Half  

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Andrographolide protects against cigarette smoke-induced lung inflammation through activation of heme oxygenase-1 by Yang D1, Zhang W, Song L, Guo F.(PubMed)
(2) Cigarette Smoke-Induced Lung Disease Predisposes to More Severe Infection with Nontypeable Haemophilus influenzae: Protective Effects of Andrographolide by Tan WS1, Peh HY1, Liao W1, Pang CH1, Chan TK1,2, Lau SH3, Chow VT2,3, Wong WS1,4.(PubMed)
(3) Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity by Guan SP1, Tee W, Ng DS, Chan TK, Peh HY, Ho WE, Cheng C, Mak JC, Wong WS.(PubMed)