Herbal Therapy: Cinnamon - The Best Whole Food Medicine for Reduced Risk and Progression of Cognitive impairment

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food(herbal medicine) used as medical treatment,  linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.
Many researchers has raised a question of their's effectiveness because of quality of the herbs due to geographic differences, time of grown and harvest, etc. I do believe that these questions can only be answered by experience herbalist.

 Whole herbal medicine cinnamon may be used as functional food for treatment of cognitive impairment, a renown study suggested.

According to Hoseo University, water extracts of Cinnamomum cassia Blume bark (CCB; Lauraceae), effectively prevent the cognitive dysfunction through the prevention of formation of amyloid-β in induced cell death and toxicity.

Cognitive impairment is considered as an early stage of dementia, affecting memory, language, thinking and judgment

Cinnamon is a spice derived from the inner bark of tree, native to South East Asia, of over 300 species of the genus Cinnamomum, belonging to the familyLauraceae, use in herbal and traditional medicine as anti-fungal and bacteria level, to improve reproductive organ, prevent flatulence and intestinal cramping, and to treat indigestion, diarrhea, bad breath, headache, migraine, etc.

Administered orally of Cinnamomum zeylanicum (CZ) for a period of 21 days in animal model induced cognitive improvement through inhibition of certain extent of oxidative stress.

In AD mice model, cinnamon reduced accumulation of soluble oligomeric assemblies of β-amyloid polypeptide (Aβ) by inhibition of the formation of toxic Aβ oligoemers induced toxicity of Aβ on neuronal cells, thus reducing the risk of accumulation of plagues which is the early signed of AD development.

Also in animal study, the standardized lyophilized aqueous extract of cinnamon bark (LCZE) testing on learning and memory in rodents at 50, 100, and 200 mg/kg, p.o. dose levels against streptozotocin (STZ)-induced memory impairment, exhibited an improved discrimination between a familiar object and a novel object and function of neurotransmitters activity and reduced oxidative stress parameters in both brain parts.

Cinnamon and its chemical components may be beneficiary for patients in early state of Cognitive impairment. The use of the herbal medicine should be taken with care as overdoses may induce toxicity.

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Sources
(1) Effect of Cinnamomum zeylanicum extract on scopolamine-induced cognitive impairment and oxidative stress in rat by Jain S, Sangma T, Shukla SK, Mediratta PK.(PubMed)
(2) Agrimonia pilosa Ledeb., Cinnamomum cassia Blume, and Lonicera japonica Thunb. protect against cognitive dysfunction and energy and glucose dysregulation by reducing neuroinflammation and hippocampal insulin resistance in β-amyloid-infused rats by Park S1, Kang S1, Kim DS1, Moon BR1.(PubMed)
(3) Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models by Frydman-Marom A1, Levin A, Farfara D, Benromano T, Scherzer-Attali R, Peled S, Vassar R, Segal D, Gazit E, Frenkel D, Ovadia M.(PubMed)