Food Therapy: Broccoli Sprout, the Best Natural Whole Food for Treatment of Asthma

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The use of plants for healing purposes have been predated long before the existence of  modern medicine. Herbal plants have formed a fundamental sources for conventional medicine in discovery of single ingredient medication, including aspirin (from willow bark), quinine (from cinchona bark), and morphine (from the opium poppy)......

Sulforaphane, the main chemical constituent of broccoli Sprout may activate anti inflammatory activity in open upper airway for reduced risk of asthma and asthma complications.

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood.

Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.

According to the study from the UCLA team, in a total 65 participated volunteers, 3 days of oral administration of broccoli or preparations sprout of 100 grams significant increased antioxidant enzymes in compared with the placebo group.

At a maximum doses of 200 grams, broccoli sprout induced significant increase of detoxified(GSTP1) and antibody NQO1, enzymes.

In support of the above, the phase II antioxidant enzymes in the human upper airway insisred, broccoli sprout demonstrated the potential antioxidant effect to reduce the inflammation of oxidative stress in induction of airway disease, such as asthma.

A randomized controlled trial in healthy young adults, also suggested that chemical compound  isothiocyanates found in cruciferous vegetable, including broccoli sprout, exhibited anti inflammatory effects through altered serum concentrations of interleukin (IL)-6, IL-8, C-reactive protein (CRP), in increased the presence of inflammation in the body tumor, and necrosis factor (TNF) α,, involved in systemic inflammation.

Intake of cruciferous Vegetables(broccoli sprouts) have shown to reduce the circulation of proinflammatory cytokins, namely IL-6 through inhibited the expression of abnormal function of  gene Glutathione S-Transferase Theta 1(GSTT1) metabolism in lower the levels of glutathione, the anioxidant with anti inflammatory properties.

Dr. Navarro SL, the lead researchers said, " IL-6 concentrations were significantly lower on day 14 of (the double-dose cruciferous) (2xC) and (cruciferous plus apiaceous (carrot family) 1xC+A diets than with the basal diet,...respectively" and " Twenty-four-hour urinary isothiocyanate excretion was not associated with any of the inflammation markers overall; however, IL-6 was inversely associated with total isothiocyanate excretion in GSTM1(The antioxidant enzyme)".

Taking altogether, intake of broccoli sprout regularly is associated to lower the effect of proinflammatory cytokins and increase detoxified and enzymes in ameliorated airway inflammation in patient with asthma.

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Sources
(1) Broccoli may help protect against respiratory conditions like asthma by Rachel Champeau | March 02, 2009
(2) Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults by Navarro SL1, Schwarz Y2, Song X2, Wang CY2, Chen C2, Trudo SP3, Kristal AR2, Kratz M2, Eaton DL4, Lampe JW2.(PubMed)
(3) Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway by Riedl MA1, Saxon A, Diaz-Sanchez D.(PubMed)