Food Therapy: Asparagus, the Antidepressant Natural Whole Food

Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Whole food(herbal medicine) used as medical treatment,  linking health benefits in prevention, management and treatment of diseases has induced much interests in today renowned scientists.
But many researchers have raised question of herbal quality, because geographic differences, time of grown and harvest, etc. may effect their's potency. I do believe, these questions can only be answered by experience herbalists.

Asparagus racemosus(AR)may be beneficiary for patients with depression, recent study conducted by theBanaras Hindu University suggested.

In an oral administration of methanolic extract of roots of AR (MAR) of the doses of 100, 200 and 400 mg/kg daily for 7 days and then subjected to forced swim test(FST), the extract decreased immobility in FST and increased avoidance response in learned helplessness test (LH), indicating antidepressant activity.

Dr. said, " MAR has significant antidepressant activity and this effect is probably mediated through the serotonergic and the noradrenergic systems(involved neurotransmitter release in nervous system) and augmentation of antioxidant defenses"

Asparagus is a flowering plant belong to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa and western Asia, used from early times as a vegetable and medicine, because of its delicate flavour and diuretic properties.

Depression is a normal response as part of our daily lives such as the loss of s job, the death of a love one, and illness. Over 30 million Americans suffer from depression and the amount is increasing in an alarming rate.

Other extract, such as Extracts of Asparagus cochinchinensis (AC) also expressed the anti depressive effects, through inhibited oxidative stress cause of neuro cell damage and improved cell signal repose and signal transmitting.

Some researchers suggested that antidepressant activity of Asparagus racemosus (AR) may also be mediated by the neurotransmitters system, and cgonitive activities possibly through the cholinergic system involved neuromuscular junctions, preganglionic neurons of the sympathetic nervous system.... 

Furthermore, the study also showed that AR may be used as food and have potential drug-drug, drug-food and food-food interactions with drugs and foods, sharing the cholinergic and monoaminergic pathways in sending message between neuro cells, induced protective activities against development of depression.

The efficacy of Asparagus in ameliorated depression through neuroprotective effect by inhibited free radical causes of neuro cell damage and improved cell signal response and signal transmitting may require further mutli and lager size studies  to confirm its validation.

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Sources
(1) Antidepressant activity of Asparagus racemosus in rodent models by Singh GK1, Garabadu D, Muruganandam AV, Joshi VK, Krishnamurthy S.(PubMed)
(2) The neuroprotective effects and possible mechanism of action of a methanol extract from Asparagus cochinchinensis: In vitro and in vivo studies by Jalsrai A1, Numakawa T2, Kunugi H2, Dieterich DC3, Becker A4.(PubMed)
(3) Asparagus racemosus competitively inhibits in vitro the acetylcholine and monoamine metabolizing enzymes by Meena J1, Ojha R, Muruganandam AV, Krishnamurthy S.(PubMed)
(4) Behavioural and neurochemical evaluation of Perment an herbal formulation in chronic unpredictable mild stress induced depressive model by Ramanathan M1, Balaji B, Justin A.(PubMed)