Most Common Disease of50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs)- Gout - The Top immune enhancers - Selenium

Kyle J. Norton (Scholar and Master of Nutrients, all right reserved)Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. According to a community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home, musculoskeletal pain was reported by 57% of those interviewed(*).

Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                          Gout

Gout mostly effected one joint is an acute and recurrent condition of arthritis as a result of uric acid building up in blood, inducing joint inflammation.

The Top immune enhancers

Enhancing immunity has shown to reduced risk of inflammatory diseases(218). The University of Calgary study insisted "Uric acid crystals [monosodium urate (MSU)] have emerged as an important factor for both gouty arthritis and immune regulation. This simple crystalline structure appears to activate innate host defense mechanisms in multiple ways and triggers robust inflammation and immune activation"(219)

2. Selenium

Selenium is one of most powerful antioxidant, played an important role in enhancing immune system fighting against forming of free radicals and foreign invasion, epidemiological evidences suggested.

In the follow up of serum selenium (Se) concentrations in 117 hemodialysis patients (HPs) during a 2-year longitudinal study, the University of Granada found that dyslipidemia and hyperuricemia found have a  negative correlation between the serum Se and uric acid levels(224).

The observation of total antioxidant capacity, including selenium was significantly higher in non-responders and well correlated with hyperuricemia(225).

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By addressing the Underlying Causes through Clinical Trials and Studies

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References

(218) Immunity, inflammation, and cancer by Grivennikov SI1, Greten FR, Karin M.(PubMed)

(219) Monosodium urate crystals in inflammation and immunity by Shi Y1, Mucsi AD, Ng G.(PubMed)

(223) An omega-3 polyunsaturated fatty acid concentrate increases plasma high-density lipoprotein 2 cholesterol and paraoxonase levels in patients with familial combined hyperlipidemia by Calabresi L1, Villa B, Canavesi M, Sirtori CR, James RW, Bernini F, Franceschini G.(PubMed)
(224) Altered serum selenium and uric acid levels and dyslipidemia in hemodialysis patients could be associated with enhanced cardiovascular risk by Martí del Moral L1, Agil A, Navarro-Alarcón M, López-Ga de la Serrana H, Palomares-Bayo M, Oliveras-López MJ.(PubMed)
(225) Urinary nitrite/nitrate concentrations and total antioxidant capacity in patients with chronic hepatitis C in therapy with interferon and ribavirin by Stanzial AM1, Benoni G, Cuzzolin L, Gabrielli GB, Pasino M, Perfetti P, Corrocher R.(PubMed)