By Kyle J. Norton
Health article writer and researcher; Over 10.000
articles and research papers have been written and published on line,
including world wide health, ezine articles, article base, healthblogs,
selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by
Disilgold.com Named 50 of the best health Tweeters Canada - Huffington
Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as
international journal Pharma and Bio science, ISSN 0975-6299.
Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome
is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles
clumping on the ovaries that interferes with the function of the normal
ovaries associated
with a high risk for metabolic disorder(1) as resulting of enlarged
ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight
gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1
in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).
In Traditional Chinese Perspective
While conventional medicine focus of using synthetic medication to
induce ovulation and assisted artificial insemination for infertility
couple, if the medicine fail, traditional Chinese medicine views
polycystic ovarian syndrome in different approaches.
Polycystic
ovary syndrome, according to traditional Chinese medicine is a medical
condition characterized by accumulative of fluid over a prolonged period
of time causes of dampness and phlegms(1247a)(1247b) build up on the
ovaries due to the effects of vary differentiations, affecting not only
the women’s menstrual cycle, but also ovulation and
fertility(1247a)(1247b).
The Nutritional Supplements according to Traditional Chinese medicine
3. Chromium
Chromium, a micro
nutrient and trace mineral, found abundantly in whole grain products
and certain fruits and vegetables such as broccoli, potatoes, grape
juice, and oranges, and lean meats, poultry, fish, beans, eggs, and
nuts,(1504) plays an important in the metabolism and storage of fats, carbohydrates and protein in the body(1503).
The
US dietary guidelines for adequate daily chromium intake were lowered
in 2001 from 50–200 µg for an adult to 30–35 µg (adult male) and to
20–25 µg (adult female), according to Journal of academic of nutrition
and dietetics(1505).
Chronic chromium
deficiency may cause symptoms of severely impaired glucose
tolerance(1506)(1507), weight loss(1506)(1508), and a metabolic
encephalopathylike confusional state(1506), induce risk of
prediabetes(1509)in predicted diabetes(1509)(1510)(1513)
and atherosclerosis(1510),...
Strong evidences from epidemiological studies suggested that chromium
exhibits anti metabolic syndrome(1511)(1514)(1515) and cardiovascular
disease(1511)(1512)(1513) including hypertension(1516)(1517),
obesity(1518)(1519), elevated fasting plasma glucose(1520)(1521), high
serum triglycerides(1522)(1523), and dyslipidaemia(1510)(1521), etc,, ,
anti insulin resistance(1510)(1519), anti depression, anti diabetes(1513)(1512), etc,.... effects.
5. Lipoic acid (LA)
Lipoic acid, also known as alpha lipoic acid(ALA), an organosulfur compound derived from octanoic acid, play an essential for aerobic metabolism to turn nutrients into energy and remove wastes through cellular respiration(1524), found abundantly in spinach,
broccoli, yams, potatoes, yeast, tomatoes, Brussels sprouts, carrots,
beets, rice bran, especially in organic red meat, etc,....... The
supplement has shown to be effective in ameliorate blood
glucose(1531)(1532) through reduced suppression of insulin expression
in β-cell(1535), reduced nerve damage induced diabetes(1533)(1534),
neurodegeneration disease(1558)(1559), skin aging(1560)(1561), improved
antioxidant(1527)(1528)(1530), anti inflammatory(1526)(1528) and immune
status(1525)(1526)(1527)(1528), reduced symptoms of vitamin E deficiency(1529), etc,....
According to studies, LA also processes anti cancer(1570)(1571)(1572), anti insulin sensitivity(1532)(1564), and anti metabolic syndrome(1532)(1563)(1562), such as hypertension(1564)(1565),
obesity(1566)(1567), elevated fasting plasma
glucose(1568)(1569) and
dyslipidaemia(1556)(1557), etc,... effects of which may contribute to
management and treatment of women with PCOs, depending to
differentiation.
Ovarian Cysts And PCOS Elimination
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome:
a complex condition with psychological, reproductive and metabolic
manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1,
Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A,
Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael
C, Lambrinoudaki I.(PubMed)
(1246) [Clinical study of area of
Jiangsu province of polycystic ovarian syndrome correlation distribution
of traditional Chinese medicine syndrome type and improper diet].
[Article in Chinese] by Feng Y, Gao YP.(PubMed)
(1247) [Preliminary
study on relationship of disease-syndrome-symptom of ovulatory disorder
infertility based on factor analysis]. [Article in Chinese] by Li M, Ma
K, Shan, J.(PubMed)
(1247a) A Comprehensive Treatment of Polycystic Ovarian Syndrome (PCOS) bny by Liqin Zhao
(1524) Lipoic acid (LA)(Wikipedia)
(1525) Alpha-lipoic acid is an effective inhibitor of human immuno-deficiency virus (HIV-1) replication by Baur A1, Harrer T, Peukert M, Jahn G, Kalden JR, Fleckenstein B.(PubMed)
(1526) Alpha-lipoic acid effects on brain glial functions accompanying double-stranded RNA antiviral and inflammatory signaling by Scumpia PO1, Kelly-Scumpia K1, Stevens BR2.(PubMed)
(1527) α-Lipoic acid
enhances endogenous peroxisome-proliferator-activated receptor-γ to
ameliorate experimental autoimmune encephalomyelitis in mice by Wang KC1, Tsai CP, Lee CL, Chen SY, Lin GJ, Yen MH, Sytwu HK, Chen SJ.(PubMed)
(1528) Effects of lipoic acid
on immune function, the antioxidant defense system, and
inflammation-related genes expression of broiler chickens fed aflatoxin
contaminated diets by Li Y1, Ma QG2, Zhao LH3, Wei H4, Duan GX5, Zhang JY6, Ji C7.(PubMed)
(1529) Alpha-lipoic acid supplementation prevents symptoms of vitamin E deficiency by Podda M1, Tritschler HJ, Ulrich H, Packer L.(PubMed)
(1530) Oxidative stress participates in the breakdown of neuronal phenotype in experimental diabetic neuropathy by Hounsom L1, Corder R, Patel J, Tomlinson DR.(PubMed)
(1531) Circulating irisin and glucose metabolism in overweight/obese women: effects of α-lipoic acid and eicosapentaenoic acid by Huerta AE1, Prieto-Hontoria PL, Fernández-Galilea M, Sáinz N, Cuervo M, Martínez JA, Moreno-Aliaga MJ.(PubMed)
(1532) Alpha-lipoic acid attenuates insulin resistance and improves glucose metabolism in high fat diet-fed mice. by Yang Y1, Li W2, Liu Y2, Li Y2, Gao L3, Zhao JJ4.(PubMed)
(1533) Activation of JNK in sensory neurons protects against sensory neuron cell death in diabetes and on exposure to glucose/oxidative stress in vitro by Price SA1, Hounsom L, Purves-Tyson TD, Fernyhough P, Tomlinson DR.(PubMed)
(1534) Nitrosative injury and antioxidant therapy in the management of diabetic neuropathy by Cowell RM1, Russell JW.(PubMed)
(1355) Alpha-lipoic acid treatment reverses 2-deoxy-D-ribose-induced oxidative damage and suppression of insulin expression in pancreatic beta-cells by Koh G1, Yang EJ, Kim MK, Lee SA, Lee DH.(PubMed)
(1556) Alpha-lipoic acid attenuates adipocyte differentiation and lipid accumulation in 3T3-L1 cells via AMPK-dependent autophagy by Hahm JR1, Noh HS2, Ha JH3, Roh GS4, Kim DR5.(PubMed)
(1557) Dyslipidemia and oxidative stress in PCOS by Macut D1, Bjekić-Macut J, Savić-Radojević A.(PubMed)
(1558) (R)-(+)-α-lipoic acid
protected NG108-15 cells against H₂O₂-induced cell death through
PI3K-Akt/GSK-3β pathway and suppression of NF-κβ-cytokines by Kamarudin
MN1, Mohd Raflee NA1, Hussein SS1, Lo JY1, Supriady H1, Abdul Kadir H1.(PubMed)
(1559) Oxidative modification of lipoic acid by HNE in Alzheimer disease brain by Hardas SS1, Sultana R, Clark AM, Beckett TL, Szweda LI, Murphy MP, Butterfield DA.(PubMed)
(1560) The clinical efficacy of cosmeceutical application of liquid crystalline nanostructured dispersions of alpha lipoic acid as anti-wrinkle by Sherif S1, Bendas ER2, Badawy S1.(PubMed)
(1561) Hypo-collagenesis in photoaged skin predicts response to anti-aging cosmeceuticals by Sachs DL1, Rittié L, Chubb HA, Orringer J, Fisher G, Voorhees JJ.(PubMed)
(1562) The
effect of lipoic acid and vitamin E therapies in individuals with the
metabolic syndrome by Manning PJ1, Sutherland WH, Williams SM, Walker
RJ, Berry EA, De Jong SA, Ryalls AR.(PubMed)
(1563) α-Lipoic
acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1)
and activation of AMP-activated protein kinase by Chen WL1, Kang CH,
Wang SG, Lee HM.(PubMed)
(1564) Prevention
of hypertension, insulin resistance, and oxidative stress by
alpha-lipoic acid by El Midaoui A1, de Champlain J.(PubMed)
(1565) The
effects of α-lipoic acid on aortic injury and hypertension in the rat
remnant kidney (5/6 nephrectomy) model by Ergür BU1, Cilaker Mıcılı S,
Yılmaz O, Akokay P.(PubMed)
(1566) Alpha-lipoic
acid supplementation: a tool for obesity therapy? by Carbonelli MG1, Di
Renzo L, Bigioni M, Di Daniele N, De Lorenzo A, Fusco MA.(PubMed)
(1567) Anti-obesity
effects of alpha-lipoic acid mediated by suppression of hypothalamic
AMP-activated protein kinase by Kim MS1, Park JY, Namkoong C, Jang PG,
Ryu JW, Song HS, Yun JY, Namgoong IS, Ha J, Park IS, Lee IK, Viollet B,
Youn JH, Lee HK, Lee KU.(PubMed)
(1568) α-lipoic
acid can improve endothelial dysfunction in subjects with impaired
fasting glucose by Xiang G1, Pu J, Yue L, Hou J, Sun H.(PubMed)
(1569) The
antioxidant alpha-lipoic acid improves endothelial dysfunction induced
by acute hyperglycaemia during OGTT in impaired glucose tolerance by
Xiang GD1, Sun HL, Zhao LS, Hou J, Yue L, Xu L.(PubMed)
(1570) Revisiting
the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol for people
with metastatic and nonmetastatic pancreatic cancer: a report of 3 new
cases by Berkson BM1, Rubin DM, Berkson AJ.(PubMed)
(1571) Chemopreventive
potential of alpha lipoic acid in the treatment of colon and cervix
cancer cell lines by Damnjanovic I, Kocic G, Najman S, Stojanovic S,
Stojanovic D, Veljkovic A, Conic I, Langerholc T, Pesic S.(PubMed)
(1572) The
importance of 1,2-dithiolane structure in α-lipoic acid for the
downregulation of cell surface β1-integrin expression of human bladder
cancer cells by Yamasaki M1, Soda S, Sakakibara Y, Suiko M, Nishiyama
K.(PubMed)
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